ZFIN ID: ZDB-LAB-170609-1
Xiao-Yan Wen Lab
PI/Director: Wen, Xiao-Yan
Contact Person:
Email:
URL:
Address: St. Michael's Hospital - Wen lab, 209 Victoria Street, LKSKI 4th Floor, Toronto, Ontario, Canada M5B 1T8
Country: Canada
Phone: 416-864-6060 x77623
Fax:
Line Designation: smh


GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Shi, X., Zhang, Y., Gong, Y., Chen, M., Brand-Arzamendi, K., Liu, X., Wen, X.Y. (2020) Zebrafish hhatla is involved in cardiac hypertrophy. Journal of Cellular Physiology. 236(5):3700-3709
Shi, X., Zhang, Y., Chen, R., Gong, Y., Zhang, M., Guan, R., Rotstein, O.D., Liu, X., Wen, X.Y. (2020) ndufa7 plays a critical role in cardiac hypertrophy. Journal of Cellular and Molecular Medicine. 24(22):13151-13162
Ichino, N., Serres, M.R., Urban, R.M., Urban, M.D., Treichel, A.J., Schaefbauer, K.J., Greif, L.E., Varshney, G.K., Skuster, K.J., McNulty, M.S., Daby, C.L., Wang, Y., Liao, H.K., El-Rass, S., Ding, Y., Liu, W., Anderson, J.L., Wishman, M.D., Sabharwal, A., Schimmenti, L.A., Sivasubbu, S., Balciunas, D., Hammerschmidt, M., Farber, S.A., Wen, X.Y., Xu, X., McGrail, M., Essner, J.J., Burgess, S.M., Clark, K.J., Ekker, S.C. (2020) Building the vertebrate codex using the gene breaking protein trap library. eLIFE. 9:
Mauro, A., Ng, R., Li, J.Y., Guan, R., Wang, Y., Singh, K.K., Wen, X.Y. (2019) Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish. PLoS One. 14:e0221796
van Karnebeek, C.D.M., Ramos, R.J., Wen, X.Y., Tarailo-Graovac, M., Gleeson, J.G., Skrypnyk, C., Brand-Arzamendi, K., Karbassi, F., Issa, M.Y., van der Lee, R., Drögemöller, B.I., Koster, J., Rousseau, J., Campeau, P.M., Wang, Y., Cao, F., Li, M., Ruiter, J., Ciapaite, J., Kluijtmans, L.A.J., Willemsen, M.A.A.P., Jans, J.J., Ross, C.J., Wintjes, L.T., Rodenburg, R.J., Huigen, M.C.D.G., Jia, Z., Waterham, H.R., Wasserman, W.W., Wanders, R.J.A., Verhoeven-Duif, N.M., Zaki, M.S., Wevers, R.A. (2019) Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy. American journal of human genetics. 105(3):534-548
Bose, P., Tremblay, E., Maois, C., Narasimhan, V., Armstrong, G.A.B., Liao, M., Parker, J.A., Robitaille, R., Wen, X.Y., Barden, C., Drapeau, P. (2019) The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 16(4):1149-1166
Kellum, J.A., Wen, X., de Caestecker, M.P., Hukriede, N.A. (2019) Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions. Nephron. 143(3):174-178
Wen, X.Y., Tarailo-Graovac, M., Brand-Arzamendi, K., Willems, A., Rakic, B., Huijben, K., Da Silva, A., Pan, X., El-Rass, S., Ng, R., Selby, K., Philip, A.M., Yun, J., Ye, X.C., Ross, C.J., Lehman, A.M., Zijlstra, F., Bakar, A.A., Drögemöller, B., Moreland, J., Wasserman, W.W., Vallance, H., van Scherpenzeel, M., Karbassi, F., Hoskings, M., Engelke, U., de Brouwer, A., Wevers, R.A., Pshezhetsky, A.V., van Karnebeek, C.D., Lefeber, D.J. (2018) Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function. JCI insight. 3(24):
Leung, C.H., Caldarone, C.A., Guan, R., Wen, X.Y., Ailenberg, M., Kapus, A., Szaszi, K., Rotstein, O.D. (2018) Nrf2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock. Antioxidants & redox signaling. 30(14):1760-1773
Moore, M.J., El-Rass, S., Xiao, Y., Wang, Y., Wen, X.Y., Kolios, M.C. (2018) Simultaneous ultra-high frequency photoacoustic microscopy and photoacoustic radiometry of zebrafish larvae in vivo.. Photoacoustics. 12:14-21
Ashikov, A., Abu Bakar, N., Wen, X.Y., Niemeijer, M., Rodrigues Pinto Osorio, G., Brand-Arzamendi, K., Hasadsri, L., Hansikova, H., Raymond, K., Vicogne, D., Simon, M.E.H., Pfundt, R., Timal, S., Beumers, R., Biot, C., Smeets, R., Kersten, M., Huijben, K., CDG group , Ta Linders, P., van den Bogaart, G., van Hijum, S.A.F.T., Rodenburg, R., van den Heuvel, L.P., van Spronsen, F., Honzik, T., Foulquier, F., van Scherpenzeel, M., Lefeber, D.J. (2018) Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation. Human molecular genetics. 27(17):3029-3045
Shi, X., Chen, R., Zhang, Y., Yun, J., Brand-Arzamendi, K., Liu, X., Wen, X.Y. (2018) Zebrafish heart failure models: opportunities and challenges. Amino Acids. 50(7):787-798
Yan, M.S., Turgeon, P.J., Man, H.S.J., Dubinsky, M.K., Ho, J.J.D., El-Rass, S., Wang, Y.D., Wen, X.Y., Marsden, P.A. (2018) Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation. The Journal of biological chemistry. 293(12):4381-4402
Patten, S.A., Aggad, D., Martinez, J., Tremblay, E., Petrillo, J., Armstrong, G.A., La Fontaine, A., Maios, C., Liao, M., Ciura, S., Wen, X.Y., Rafuse, V., Ichida, J., Zinman, L., Julien, J.P., Kabashi, E., Robitaille, R., Korngut, L., Parker, J.A., Drapeau, P. (2017) Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis. JCI insight. 2(22)
Zabinyakov, N., Bullivant, G., Cao, F., Fernandez Ojeda, M., Jia, Z.P., Wen, X.Y., Dowling, J.J., Salomons, G.S., Mercimek-Andrews, S. (2017) Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology. PLoS One. 12:e0186645
Philip, A.M., Wang, Y., Mauro, A., El-Rass, S., Marshall, J.C., Lee, W.L., Slutsky, A.S., dos Santos, C.C., Wen, X.Y. (2017) Development of a zebrafish sepsis model for high-throughput drug discovery. Molecular medicine (Cambridge, Mass.). 23:134-148
Shi, X., Verma, S., Yun, J., Brand-Arzamendi, K., Singh, K.K., Liu, X., Garg, A., Quan, A., Wen, X.Y. (2017) Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?. Molecular and cellular biochemistry. 433(1-2):97-102
McCutcheon, V., Park, E., Liu, E., Sobhe Bidari, P., Tavakkoli, J., Wen, X.Y., Baker, A.J. (2017) A novel model of traumatic brain injury in adult zebrafish demonstrates response to injury and treatment comparable with mammalian models. Journal of neurotrauma. 34(7):1382-1393
El-Rass, S., Eisa-Beygi, S., Khong, E., Brand-Arzamendi, K., Mauro, A., Zhang, H., Clark, K.J., Ekker, S.C., Wen, X.Y. (2017) Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly.. Biology Open. 6(3):348-357