ZFIN ID: ZDB-LAB-170209-10
Jie He Lab
PI/Director: He, Jie
Contact Person: He, Jie
Email: jiehe@ion.ac.cn
Address: Laboratory of Stem Cells and Neurogenesis Institute of Neuroscience Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031, China
Country: China
Phone: 86-21-54921731
Line Designation: ion

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Brain complexity is implemented by astounding diversity of cell types connected in appropriate numbers and combinations. The precise control of neural progenitor/stem cell (NPC/NSC) division and differentiation is a prerequisite for the development and maintenance of circuit integrity, plasticity and regeneration. In the laboratory, our present interest is to develop various genetic and optical tools, by which we hope to gain access to the complete development from single stem (progenitor) cells to their progeny-derived neural circuits in distinct brain regions of zebrafish (Danio rerio), and thereby elucidating the fundamental logics underlying the determination of cell number, neuronal diversity, functional property of neural circuits.

Agnihotri, Sandeep Kumar Post-Doc Du, Lei Graduate Student Jin, Mengmeng Graduate Student
Li, Yan Graduate Student Li, Yanan Graduate Student Qin, Huiwen Graduate Student
Wang, Mei Graduate Student Xu, Baijie Graduate Student Yang, Jian Graduate Student
Yu, Shuguang Graduate Student Zhang, Hui Graduate Student Tang, Xia Research Staff
Jia, Xinling Administrative Staff Qiu, Xiaoying Administrative Staff Shen, Xiaoyu Administrative Staff

Wang, M., Du, L., Lee, A.C., Li, Y., Qin, H., He, J. (2020) Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes. The Journal of cell biology. 219(9):
Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
He, M., Halima, M., Xie, Y., Schaaf, M.J.M., Meijer, A.H., Wang, M. (2020) Ginsenoside Rg1 Acts as a Selective Glucocorticoid Receptor Agonist with Anti-Inflammatory Action without Affecting Tissue Regeneration in Zebrafish Larvae. Cells. 9(5):
Wang, H., Yang, Z., Li, X., Huang, D., Yu, S., He, J., Li, Y., Yan, J. (2020) Single-cell in vivo imaging of cellular circadian oscillators in zebrafish. PLoS Biology. 18:e3000435
Zhao, Y., Han, Y., Wang, Z., Chen, T., Qian, H., He, J., Li, J., Han, B., Wang, T. (2020) Rosmarinic acid protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity in zebrafish embryos. Toxicology in vitro : an international journal published in association with BIBRA. 65:104823
Yan, S.C., Chen, Z.F., Zhang, H., Chen, Y., Qi, Z., Liu, G., Cai, Z. (2020) Evaluation and optimization of sample pretreatment for GC/MS-based metabolomics in embryonic zebrafish. Talanta. 207:120260
Cheng, B., Zhang, H., Hu, J., Peng, Y., Yang, J., Liao, X., Liu, F., Guo, J., Hu, C., Lu, H. (2020) The immunotoxicity and neurobehavioral toxicity of zebrafish induced by famoxadone-cymoxanil. Chemosphere. 247:125870
Li, Y., Agrawal, I., Gong, Z. (2019) Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene transgenic zebrafish model. Disease models & mechanisms. 12(10):
Zhang, Z., Hou, H., Yu, S., Zhou, C., Zhang, X., Li, N., Zhang, S., Song, K., Lu, Y., Liu, D., Lu, H., Xu, H. (2019) Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia. 68(1):111-127
Yu, S., He, J. (2019) Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish. eLIFE. 8
Zhang, Y., Takagi, N., Yuan, B., Zhou, Y., Si, N., Wang, H., Yang, J., Wei, X., Zhao, H., Bian, B. (2019) The protection of indolealkylamines on LPS-induced inflammation in zebrafish. Journal of ethnopharmacology. 243:112122
Jiang, Y.X., Shi, W.J., Ma, D.D., Zhang, J.N., Ying, G.G., Zhang, H., Ong, C.N. (2019) Male-biased zebrafish sex differentiation and metabolomics profile changes caused by dydrogesterone. Aquatic toxicology (Amsterdam, Netherlands). 214:105242
Zhang, R., He, J., Wang, X., Pan, W., Cao, Y., Zu, Y., Jiang, Q., Du, J., Zhong, T.P. (2018) Report of the Fifth Zebrafish Research Conference of China. Zebrafish. 16(1):128-134
Zheng, Y., Liu, C., Li, Y., Jiang, H., Yang, P., Tang, J., Xu, Y., Wang, H., He, Y. (2018) Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency. Biology of reproduction. 100(4):1066-1072
He, M., Huang, X., Liu, S., Guo, C., Xie, Y., Meijer, A.H., Wang, M. (2018) The Difference between White and Red Ginseng: Variations in Ginsenosides and Immunomodulation. Planta Medica. 84(12-13):845-854
Tang, X., Gao, J., Jia, X., Zhao, W., Zhang, Y., Pan, W., He, J. (2017) Bipotent progenitors as embryonic origin of retinal stem cells. The Journal of cell biology. 216(6):1833
Goodings, L., He, J., Wood, A., Harris, W.A., Currie, P.D., Jusuf, P.R. (2017) In vivo expression of Nurr1/Nr4a2a in developing retinal amacrine subtypes in zebrafish Tg(nr4a2a:eGFP) transgenics. The Journal of comparative neurology. 525(8):1962-1979
Zhou, Y., Li, P., Brantner, A., Wang, H., Shu, X., Yang, J., Si, N., Han, L., Zhao, H., Bian, B. (2017) Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients. Scientific Reports. 7:44660
Li, Y., Li, H., Spitsbergen, J.M., Gong, Z. (2017) Males develop faster and more severe hepatocellular carcinoma than females in krasV12 transgenic zebrafish.. Scientific Reports. 7:41280
Huang, Y., Luo, Y., Liu, J., Gui, S., Wang, M., Liu, W., Peng, L., Xiao, Y. (2017) A light-colored region of caudal fin: a niche of melanocyte progenitors in crucian carp (Cyprinus carpio L.). Cell biology international. 41:42-50
Rawnsley, D.R., Xiao, J., Lee, J.S., Liu, X., Mericko-Ishizuka, P., Kumar, V., He, J., Basu, A., Lu, M., Lynn, F.C., Pack, M., Gasa, R., Kahn, M.L. (2013) The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. The Journal of biological chemistry. 288:24429-40
He, J., Zhang, G., Almeida, A.D., Cayouette, M., Simons, B.D., and Harris, W.A. (2012) How variable clones build an invariant retina. Neuron. 75(5):786-798