ZFIN ID: ZDB-LAB-170208-8
Development and functional regulation of BBB
PI/Director: Zhang, Jingjing
Contact Person: Zhang, Jingjing
Email: jj.zhang@gdmu.edu.cn; gdmccrc@163.com
URL: http://www.gdmch.com/zebrafish
Address: Clinical Research Center, Affiliate Hospital of Guangdong Medical University Nr. 57 Renmin Dadao Nan, Zhanjiang 524001, China
Country: China
Phone: +86-759-2387140
Line Designation: gyf

Show all 17 genomic features

The research interests of our lab are the development and functional modulations of tissue barriers including blood-brain barrier (BBB) and epithelial barriers. Using in vitro systems, zebrafish and mice models, our group focuses on (1) the developmental roles of Claudin family members on the barrier formation; (2) using synthesized peptides to selectively open tight junctions for the drug delivery; (3) the interactions between endothelial cells and pericytes and/or astrocytes during BBB formation; (4) protective and repair mechanisms under pathological and ischemic conditions.


Yang, Z., Wu, S., Fontana, F., Li, Y., Xiao, W., Gao, Z., Stephan, A., Affolter, M., Belting, H.G., Abdelilah-Seyfried, S., Zhang, J. (2020) The tight junctions protein Claudin-5 limits endothelial cell motility. Journal of Cell Science. 134(1):
Gan, D., Wu, S., Chen, B., Zhang, J. (2019) Application of the Zebrafish Traumatic Brain Injury Model in Assessing Cerebral Inflammation. Zebrafish. 17(2):73-82
Huang, Y., Lu, Y., He, Y., Feng, Z., Zhan, Y., Huang, X., Liu, Q., Zhang, J., Li, H., Huang, H., Ma, M., Luo, L., Li, L. (2019) Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 & Irf4 in zebrafish. The Journal of biological chemistry. 294(44):16152-16163
Zhan, Y., Huang, Y., Chen, J., Cao, Z., He, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2018) The caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao.
Zheng, Y., Li, J., Wu, J., Yu, Y., Yao, W., Zhou, M., Tian, J., Zhang, J., Cui, L., Zeng, X., Liu, Y. (2017) Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity.. Experimental and Therapeutic Medicine. 14:2845-2852
Zhang, J., Qi, J., Wu, S., Peng, L., Shi, Y., Yang, J., Yin, Z., Gao, Y., Wang, C., Gong, J., Zhang, H., Zhang, J., Liu, D. (2017) Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Frontiers in Physiology. 8:214
Zhang, J.J., Wang, X., Liu, D. (2017) [Natriuretic peptide precursor C coding gene contributes to zebrafish angiogenesis]. Sheng li xue bao : [Acta physiologica Sinica]. 69:11-16
Hou, Y., Sheng, Z., Mao, X., Li, C., Chen, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2016) Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue. Scientific Reports. 6:36853
Luo, S., Yang, Y., Chen, J., Zhong, Z., Huang, H., Zhang, J., Cui, L. (2015) Tanshinol stimulates bone formation and attenuates dexamethasone-induced inhibition of osteogenesis in larval zebrafish. Journal of orthopaedic translation. 4:35-45