ZFIN ID: ZDB-LAB-160721-2
Quintana Lab
PI/Director: Quintana, Anita
Contact Person: Quintana, Anita
Email: aquintana8@utep.edu
URL: http://expertise.utep.edu/profiles/aquintana8
Address: 500 West University Ave, El Paso TX 79968
Country: United States
Phone: 915-747-6181
Fax:
Line Designation: ute


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
The Quintana lab focus is to understand the mechanisms underlying multiple congenital anomaly syndrome. Our work begins with patients in the clinic and we use high throughput genetic sequencing approaches to identify novel genes associated with disease. Many of the disorders we study are very rare making it difficult to label genetic variations as causal. To circumvent this problem we have turned to the developing zebrafish embryo. We use CRISPR/Cas9 mediated mutagenesis to mutate candidate genes identified via whole exome sequencing and then study the cellular and molecular consequences associated with mutation. Our projects span neural crest cell development, focusing primarily on cranial neural crest cells and Schwann cells, neural developmental mechanisms, focusing primarily on neural precursor differentiation, and most recently hematopoiesis. Our work has the potential to revolutionize how we treat multiple congenital anomaly syndromes and is a testament to the power of zebrafish as a model to inform about human disease.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Castellanos, B.S., Reyes-Nava, N.G., Quintana, A.M. (2021) Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish. BMC Developmental Biology. 21:7
Castro, V.L., Reyes-Nava, N.G., Sanchez, B.B., Gonzalez, C.G., Paz, D., Quintana, A.M. (2020) Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism. Genesis (New York, N.Y. : 2000). 58(12):e23397
Castro, V.L., Reyes, J.F., Reyes-Nava, N.G., Paz, D., Quintana, A.M. (2020) Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain. BMC Neuroscience. 21:27
Reyes-Nava, N., Yu, H.C., Coughlin, C.R., Shaikh, T.H., Quintana, A.M. (2020) Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish. Biology Open. 9(4):
Hernandez, J.A., Castro, V.L., Reyes-Nava, N., Montes, L.P., Quintana, A.M. (2019) Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development. Blood advances. 3:1244-1254
Quintana, A.M., Yu, H.C., Brebner, A., Pupavac, M., Geiger, E.A., Watson, A., Castro, V.L., Cheung, W., Chen, S.H., Watkins, D., Pastinen, T., Skovby, F., Appel, B., Rosenblatt, D.S., Shaikh, T.H. (2017) Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities. Human molecular genetics. 26(15):2838-2849
Quintana, A.M., Hernandez, J.A., Gonzalez, C.G. (2017) Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development. PLoS One. 12:e0180856