Lab
The Wang Laboratory
|
|
Statement of Research Interest
Most organisms display daily changes at molecular, cellular, physiological, and behavioral levels, which are known as circadian rhythms. The circadian clock controls fundamental life processes such as the human sleep-wake cycle. Many human sleep disorders and dysrhythmias are thought to result from circadian defects. A full molecular genetic understanding of circadian rhythmicity is critical for diagnosis, prevention and treatment of human dysrhythmias. We study molecular genetic mechanisms underlying zebrafish circadian rhythmicity. Using TALEN and CRISPR-Cas9 techniques, we have generated a number of mutants for zebrafish circadian clock genes. The roles of these circadian clock genes in the circadian system and life processes are investigated.
We also used zebrafish to study a group of human diseases called porphyria, derived from defective enzymes in heme biosynthesis. We have established several zebrafish models for human porphyria. We are interested in studying novel aspects of porphyria pathogenesis.
We also used zebrafish to study a group of human diseases called porphyria, derived from defective enzymes in heme biosynthesis. We have established several zebrafish models for human porphyria. We are interested in studying novel aspects of porphyria pathogenesis.
Lab Members
| Liu, Taole Post-Doc | Deng, Bo Graduate Student | He, Wei Graduate Student |
| Huang, Guodong Graduate Student | Liu, Huazhen Graduate Student | Niu, Pengfei Graduate Student |
| Niu, Zhijie Graduate Student | Wang, Jingjing Graduate Student | Wang, Tuoyi Graduate Student |
| Xu, Shuhao Graduate Student | Yang, Fan Graduate Student | Ye, Qiang Graduate Student |
| Yuan, Shiyu Graduate Student | Zhang, Fanmiao Graduate Student | Zhang, Jiguang Graduate Student |
| Zhang, Shuqing Graduate Student | Zhang, Wei Graduate Student | Hu, Jia Technical Staff |
| Zhong, Zhaomin Technical Staff | Hu, Yingying Administrative Staff | Huang, Jian |
| Ji, Cheng |