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ZFIN ID: ZDB-LAB-150122-1
TF Fu Lab
PI/Director: Fu, Tzu-Fun
Contact Person: Tu, Hung-Chi
Address: Deparment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, No. 1 University Rd, Tainan 701, Taiwan.
Country: Taiwan
Phone: +886-6-2353535-5795
Fax: +886-6-2363956
Line Designation: cku

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Kao, Tseng-Ting Post-Doc Chang, Wen-Ni Graduate Student Chen, Po-Yuan Graduate Student
Dong, Pei-Xuan Graduate Student Hsiao, Tsun-Hsien Graduate Student Lee, Gang-Hui Graduate Student
Tu, Hung-Chi Graduate Student Cheng, Nai-Wei

Wang, Y.F., Chen, I.W., Subendran, S., Kang, C.W., Panigrahi, B., Fu, T.F., Chen, C.Y. (2020) Edible additive effects on zebrafish cardiovascular functionality with hydrodynamic assessment. Scientific Reports. 10:16243
Chen, Z.Y., Li, N.J., Cheng, F.Y., Hsueh, J.F., Huang, C.C., Lu, F.I., Fu, T.F., Yan, S.J., Lee, Y.H., Wang, Y.J. (2020) The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos. International Journal of Molecular Sciences. 21(8)
Chen, P.Y., Tu, H.C., Schirch, V., Safo, M.K., Fu, T.F. (2019) Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency. Frontiers in pharmacology. 10:1086
Lee, G.H., Cheng, N.W., Yu, H.H., Tsai, J.N., Liu, T., Wen, Z.H., Chen, B.H., Fu, T.F. (2019) A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance. Scientific Reports. 9:12633
Lee, G.H., Chang, C.L., Chiu, W.T., Hsiao, T.H., Chen, P.Y., Wang, K.C., Kuo, C.H., Chen, B.H., Shi, G.Y., Wu, H.L., Fu, T.F. (2019) A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish. Journal of Biomedical Science. 26:60
Tu, H.C., Lin, M.Y., Lin, C.Y., Hsiao, T.H., Wen, Z.H., Chen, B.H., Fu, T.F. (2019) Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish. Ecotoxicology and environmental safety. 182:109380
Kang, C.P., Tu, H.C., Fu, T.F., Wu, J.M., Chu, P.H., Chang, D.T. (2018) An automatic method to calculate heart rate from zebrafish larval cardiac videos. BMC Bioinformatics. 19:169
Tu, H.C., Lee, G.H., Hsiao, T.H., Kao, T.T., Wang, T.Y., Tsai, J.N., Fu, T.F. (2017) One crisis, diverse impacts-Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae. PLoS One. 12:e0188585
Chang, W.N., Chi, W.Y., Kao, T.T., Tsai, J.N., Liu, W., Liang, S.S., Chiu, C.C., Chen, B.H., Fu, T.F. (2017) The Transgenic Zebrafish Display Fluorescence Reflecting the Expressional Dynamics of Dihydrofolate Reductase. Zebrafish. 14(3):223-235
Chiu, C.C., Chou, H.L., Chen, B.H., Chang, K.F., Tseng, C.H., Fong, Y., Fu, T.F., Chang, H.W., Wu, C.Y., Tsai, E.M., Lin, S.R., Chen, Y.L. (2015) BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model. BMC cancer. 15:962
Lin, C.C., Chuankhayan, P., Chang, W.N., Kao, T.T., Guan, H.H., Fun, H.K., Nakagawa, A., Fu, T.F., Chen, C.J. (2015) Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition. Acta crystallographica. Section D, Biological crystallography. 71:1006-1021
Fu, Y.C., Fu, T.F., Wang, H.J., Lin, C.W., Lee, G.H., Wu, S.C., Wang, C.K. (2014) Aspartic acid based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluation. Acta biomaterialia. 10(11):4583-96
Hsiao, T.H., Lin, C.J., Chung, Y.S., Lee, G.H., Kao, T.T., Chang, W.N., Chen, B.H., Hung, J.J., and Fu, T.F. (2014) Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress. Molecular and cellular biology. 34(3):498-509
Chuankhayan, P., Kao, T.T., Lin, C.C., Guan, H.H., Nakagawa, A., Fu, T.F., and Chen, C.J. (2013) Structural Insights into the Hydrolysis and Polymorphism of Methotrexate Polyglutamate by Zebrafish gamma-Glutamyl Hydrolase. Journal of medicinal chemistry. 56(19):7625-7635
Kao, T.T., Lee, G.H., Fu, C.C., Chen, B.H., Chen, L.T., and Fu, T.F. (2013) Methotrexate-Induced Decrease in Embryonic 5-Methyl-Tetrahydrofolate Is Irreversible with Leucovorin Supplementation. Zebrafish. 10(3):326-37
Lee, G.H., Sung, S.Y., Chang, W.N., Kao, T.T., Du, H.C., Hsiao, T.H., Safo, M.K., and Fu, T.F. (2012) Ginkgotoxin exposed zebrafish larvae exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. Disease models & mechanisms. 5(6):785-795
Lin, C.J., Hsiao, T.H., Chung, Y.S., Chang, W.N., Yeh, T.M., Chen, B.H., and Fu, T.F. (2011) Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1. Protein Expression and Purification. 76(1):36-43
Chang, W.N., Lin, H.C., and Fu, T.F. (2010) Zebrafish 10-formyltetrahydrofolate dehydrogenase is similar to its mammalian isozymes for its structural and catalytic properties. Protein Expression and Purification. 72(2):217-222
Kao, T.T., Tu, H.C., Chang, W.N., Chen, B.H., Shi, Y.Y., Chang, T.C., and Fu, T.F. (2010) Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism. International journal of food microbiology. 141(1-2):17-27
Kao, T.T., Chang, W.N., Wu, H.L., Shi, G.Y., and Fu, T.F. (2009) Recombinant Zebrafish γ-Glutamyl Hydrolase Exhibits Properties and Catalytic Activities Comparable with Those of Mammalian Enzyme. Drug metabolism and disposition: the biological fate of chemicals. 37(2):302-309
Kao, T.T., Wang, K.C., Chang, W.N., Lin, C.Y., Chen, B.H., Wu, H.L., Shi, G.Y., Tsai, J.N., and Fu, T.F. (2008) Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases --- Inhibition by folic acid and polyphenols. Drug metabolism and disposition: the biological fate of chemicals. 36(3):508-516
Chang, W.N., Tsai, J.N., Chen, B.H., Huang, H.S., and Fu, T.F. (2007) Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases. Drug metabolism and disposition: the biological fate of chemicals. 35(11):2127-2137
Chang, W.N., Tsai, J.N., Chen, B.H., and Fu T.F. (2006) Cloning, expression, purification, and characterization of zebrafish cytosolic serine hydroxymethyltransferase. Protein Expression and Purification. 46(2):212-220