ZFIN Lab: Kurrasch Lab

ZFIN ID: ZDB-LAB-140722-2

ZFIN ID: ZDB-LAB-140722-2

Kurrasch Lab

PI/Director:	Kurrasch, Deborah
Contact Person:	Vandenbrink, Alicia
Email:	avandenb@ucalgary.ca
URL:	http://people.ucalgary.ca/~kurrasch/kurraschlab/Welcome.html
Address:	3330 Hospital Drive NW, Room 2148 Cummings School of Medicine University of Calgary Calgary, AB T2N 4N1
Country:	Canada
Phone:	403-210-6711
Fax:
Line Designation:	ca

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

Statement of Research Interests: The Kurrasch lab studies the genetic programs that govern hypothalamic development. We are interested in cell fate decisions as well as neuronal migration mechanisms that cause neurons to coalesce into a nucleus. In addition, we examine how environmental challenges (e.g., endocrine disrupting chemicals, toxicants) perturb normal development of this region.

LAB MEMBERS

Ibhazehiebo, Kingsley Post-Doc	Zhang, Zi Wei Post-Doc	Kinch, Cassandra Graduate Student
Obasuyi, Osahon Graduate Student	Kaushik, Gaurav Research Staff	Rehak, Renata Research Staff
Vandenbrink, Alicia Administrative Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Lessey, A.J., Mirczuk, S.M., Chand, A.N., Kurrasch, D.M., Korbonits, M., Niessen, S.J.M., McArdle, C.A., McGonnell, I.M., Fowkes, R.C. (2023) Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development. International Journal of Molecular Sciences. 24(16):

Dogra, D., Meza-Santoscoy, P.L., Gavrilovici, C., Rehak, R., de la Hoz, C.L.R., Ibhazehiebo, K., Rho, J.M., Kurrasch, D.M. (2023) kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and respond to first-line therapy carbamazepine. Epilepsia. 64(8):2186-2199

Ibhazehiebo, K., Rho, J.M., Kurrasch, D.M. (2020) Metabolism-based drug discovery in zebrafish: An emerging strategy to uncover new anti-seizure therapies. Neuropharmacology. 167:107988

Ibhazehiebo, K., Gavrilovici, C., de la Hoz, C.L., Ma, S.C., Rehak, R., Kaushik, G., Meza Santoscoy, P.L., Scott, L., Nath, N., Kim, D.Y., Rho, J.M., Kurrasch, D.M. (2018) A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target. Brain : a journal of neurology. 141(3):744-761

Nesan, D., Sewell, L.C., Kurrasch, D.M. (2017) Opening the black box of endocrine disruption of brain development: Lessons from the characterization of Bisphenol A. Hormones and behavior. 101:50-58

Best, C., Kurrasch, D.M., Vijayan, M.M. (2017) Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Scientific Reports. 7:40905

Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63

Kinch, C.D., Kurrasch, D.M., Habibi, H.R. (2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands). 175:286-298

Kinch, C.D., Ibhazehiebo, K., Jeong, J.H., Habibi, H.R., Kurrasch, D.M. (2015) Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(5):1475-80

Kurrasch, D.M., Nevin, L.M., Wong, J., Baier, H., and Ingraham, H.A. (2009) Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Development. 4:22

Kurrasch, D.M., Cheung, C.C., Lee, F.Y., Tran, P.V., Hata, K., and Ingraham, H.A. (2007) The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(50):13624-13634