ZFIN ID: ZDB-LAB-140722-2
Kurrasch Lab
PI/Director: Kurrasch, Deborah
Contact Person: Vandenbrink, Alicia
Email: avandenb@ucalgary.ca
URL: http://people.ucalgary.ca/~kurrasch/kurraschlab/Welcome.html
Address: 3330 Hospital Drive NW, Room 2148 Cummings School of Medicine University of Calgary Calgary, AB T2N 4N1
Country: Canada
Phone: 403-210-6711
Line Designation: ca

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Statement of Research Interests: The Kurrasch lab studies the genetic programs that govern hypothalamic development. We are interested in cell fate decisions as well as neuronal migration mechanisms that cause neurons to coalesce into a nucleus. In addition, we examine how environmental challenges (e.g., endocrine disrupting chemicals, toxicants) perturb normal development of this region.

Ibhazehiebo, Kingsley Post-Doc Zhang, Zi Wei Post-Doc Kinch, Cassandra Graduate Student
Obasuyi, Osahon Graduate Student Kaushik, Gaurav Research Staff Rehak, Renata Research Staff
Vandenbrink, Alicia Administrative Staff

Ibhazehiebo, K., Rho, J.M., Kurrasch, D.M. (2020) Metabolism-based drug discovery in zebrafish: An emerging strategy to uncover new anti-seizure therapies. Neuropharmacology. 167:107988
Ibhazehiebo, K., Gavrilovici, C., de la Hoz, C.L., Ma, S.C., Rehak, R., Kaushik, G., Meza Santoscoy, P.L., Scott, L., Nath, N., Kim, D.Y., Rho, J.M., Kurrasch, D.M. (2018) A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target. Brain : a journal of neurology. 141(3):744-761
Nesan, D., Sewell, L.C., Kurrasch, D.M. (2017) Opening the black box of endocrine disruption of brain development: Lessons from the characterization of Bisphenol A. Hormones and behavior. 101:50-58
Best, C., Kurrasch, D.M., Vijayan, M.M. (2017) Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Scientific Reports. 7:40905
Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63
Kinch, C.D., Kurrasch, D.M., Habibi, H.R. (2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands). 175:286-298
Kinch, C.D., Ibhazehiebo, K., Jeong, J.H., Habibi, H.R., Kurrasch, D.M. (2015) Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(5):1475-80
Kurrasch, D.M., Nevin, L.M., Wong, J., Baier, H., and Ingraham, H.A. (2009) Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Development. 4:22
Kurrasch, D.M., Cheung, C.C., Lee, F.Y., Tran, P.V., Hata, K., and Ingraham, H.A. (2007) The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(50):13624-13634