ZFIN Lab: Institut National de la Recherche Agronomique, Laboratoire de Physiologie et Génomique des Poissons

ZFIN ID: ZDB-LAB-130702-1

ZFIN ID: ZDB-LAB-130702-1

Institut National de la Recherche Agronomique, Laboratoire de Physiologie et Génomique des Poissons

PI/Director:	Lareyre, Jean-Jacques Le Gac, Florence
Contact Person:	Lareyre, Jean-Jacques
Email:	jean-jacques.lareyre@rennes.inra.fr
URL:	http://www6.rennes.inra.fr/lpgp
Address:	INRA LPGP, bâtiment 16, Campus de Beaulieu, 35042 Rennes cedex
Country:	France
Phone:	+33 2 23 48 57 23
Fax:	+33 2 23 48 50 20
Line Designation:	inr

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 12 genomic features

STATEMENT OF RESEARCH INTERESTS

Our research program aims to understand the regulatory mechanisms underlying the hormonal and/or cell specific expression of genes expressed in fish testis. We have identified gene promoter fragments that target gene expression specifically in the Sertoli cells or male germ cells in zebrafish. We have also identified genes that are responsive to androgens and/or gonadotropins to unravel the specific effects of those hormones.

LAB MEMBERS

Gautier, Aude Graduate Student

Mella-Alvarado, Vanessa Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Tebo, A.G., Moeyaert, B., Thauvin, M., Carlon-Andres, I., Böken, D., Volovitch, M., Padilla-Parra, S., Dedecker, P., Vriz, S., Gautier, A. (2020) Orthogonal fluorescent chemogenetic reporters for multicolor imaging. Nature Chemical Biology. 17(1):30-38

Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137

Frétaud, M., Rivière, L., Job, É., Gay, S., Lareyre, J.J., Joly, J.S., Affaticati, P., Thermes, V. (2017) High-resolution 3D imaging of whole organ after clearing: taking a new look at the zebrafish testis. Scientific Reports. 7:43012

Gautier, A., Goupil, A.S., Le Gac, F., and Lareyre, J.J. (2013) A Promoter Fragment of the sycp1 Gene Is Sufficient to Drive Transgene Expression in Male and Female Meiotic Germ Cells in Zebrafish. Biology of reproduction. 89(4):89

Mella-Alvarado, V., Gautier, A., Le Gac, F., and Lareyre, J.J. (2013) Tissue and cell-specific transcriptional activity of the human cytomegalovirus immediate early gene promoter (UL123) in zebrafish. Gene expression patterns : GEP. 13(3-4):91-103

Gautier, A., Sohm, F., Joly, J.S., Le Gac, F., and Lareyre, J.J. (2011) The Proximal Promoter Region of the Zebrafish gsdf Gene Is Sufficient to Mimic the Spatio-Temporal Expression Pattern of the Endogenous Gene in Sertoli and Granulosa Cells. Biology of reproduction. 85(6):1240-51

Hinfray, N., Baudiffier, D., Leal, M.C., Porcher, J.M., Aït-Aïssa, S., Le Gac, F., Schulz, R.W., and Brion, F. (2011) Characterization of testicular expression of P450 17α-hydroxylase, 17,20-lyase in zebrafish and its perturbation by the pharmaceutical fungicide clotrimazole. General and comparative endocrinology. 174(3):309-17

Gautier, A., Le Gac, F., and Lareyre, J.J. (2011) The gsdf gene locus harbours evolutionary conserved and clustered genes preferentially expressed in fish previtellogenic oocytes. Gene. 472(1-2):7-17

Mouriec, K., Lareyre, J.J., Tong, S.K., Le Page, Y., Vaillant, C., Pellegrini, E., Pakdel, F., Chung, B.C., Kah, O., and Anglade, I. (2009) Early regulation of brain aromatase (cyp19a1b) by estrogen receptors during zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(10):2641-2651