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ZFIN ID: ZDB-LAB-130529-1
Mosimann Lab
PI/Director: Mosimann, Christian
Co-PI / Senior
Burger, Alexa
Contact Person: Mosimann, Christian
Address: University of Colorado Denver, School of Medicine Anschutz Medical Campus RC1 South, 12400 12801 E. 17th Avenue Aurora, CO 80045
Country: United States
Phone: +41 44 635 31 56
Line Designation: co

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We use zebrafish as our principal model system to study the mechanisms of cell fate determination in development and disease. We focus in particular on the emergence, patterning, and cell fate partitioning of the lateral plate mesoderm towards its vast array of downstream cell fates.

Riumslagh, Frederike W. Post-Doc Kocere, Agnese Graduate Student Nieuwenhuize, Susan Graduate Student
Prummel, Karin Graduate Student Kemmler, Cassie L.

Pfefferli, C., Moran, H.R., Felker, A., Mosimann, C., Jaźwińska, A. (2021) Persistent Ventricle Partitioning in the Adult Zebrafish Heart. Journal of cardiovascular development and disease. 8(4):
Kemmler, C.L., Riemslagh, F.W., Moran, H.R., Mosimann, C. (2021) From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish. Journal of cardiovascular development and disease. 8(2):
Kocere, A., Resseguier, J., Wohlmann, J., Skjeldal, F.M., Khan, S., Speth, M., Dal, N.K., Ng, M.Y.W., Alonso-Rodriguez, N., Scarpa, E., Rizzello, L., Battaglia, G., Griffiths, G., Fenaroli, F. (2020) Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis. EBioMedicine. 58:102902
Prummel, K.D., Nieuwenhuize, S., Mosimann, C. (2020) The lateral plate mesoderm. Development (Cambridge, England). 147(12):
Dal, N.K., Kocere, A., Wohlmann, J., Van Herck, S., Bauer, T.A., Resseguier, J., Bagherifam, S., Hyldmo, H., Barz, M., De Geest, B.G., Fenaroli, F. (2020) Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle-Cell Interactions. Small (Weinheim an der Bergstrasse, Germany). 16(5):e1906719
Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
Sagarin, K.A., Redgrave, A.C., Mosimann, C., Burke, A.C., Devoto, S.H. (2019) Anterior Trunk Muscle Shows Mix of Axial and Appendicular Developmental Patterns. Developmental dynamics : an official publication of the American Association of Anatomists. 248(10):961-968
D'Agati, G., Cabello, E.M., Frontzek, K., Rushing, E.J., Klemm, R., Robinson, M.D., White, R.M., Mosimann, C., Burger, A. (2019) Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Disease models & mechanisms. 12(7):
Parker, H.J., De Kumar, B., Green, S.A., Prummel, K.D., Hess, C., Kaufman, C.K., Mosimann, C., Wiedemann, L.M., Bronner, M.E., Krumlauf, R. (2019) A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Nature communications. 10:1189
Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458
Kirchgeorg, L., Felker, A., van Oostrom, M., Chiavacci, E., Mosimann, C. (2018) Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 247(10):1146-1159
Callahan, S.J., Tepan, S., Zhang, Y.M., Lindsay, H., Burger, A., Campbell, N.R., Kim, I.S., Hollmann, T.J., Studer, L., Mosimann, C., White, R.M. (2018) Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). Disease models & mechanisms. 11(9):
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
Felker, A., Prummel, K.D., Merks, A.M., Mickoleit, M., Brombacher, E.C., Huisken, J., Panáková, D., Mosimann, C. (2018) Continuous addition of progenitors forms the cardiac ventricle in zebrafish. Nature communications. 9:2001
Carney, T.J., Mosimann, C. (2018) Switch and Trace: Recombinase Genetics in Zebrafish. Trends in genetics : TIG. 34(5):362-378
Sánchez-Iranzo, H., Galardi-Castilla, M., Minguillón, C., Sanz-Morejón, A., González-Rosa, J.M., Felker, A., Ernst, A., Guzmán-Martínez, G., Mosimann, C., Mercader, N. (2018) Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nature communications. 9:428
Norris, M.L., Pauli, A., Gagnon, J.A., Lord, N.D., Rogers, K.W., Mosimann, C., Zon, L.I., Schier, A.F. (2017) Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. eLIFE. 6
D'Agati, G., Beltre, R., Sessa, A., Burger, A., Zhou, Y., Mosimann, C., White, R.M. (2017) A defect in the mitochondrial protein mpv17 underlies the transparent casper zebrafish. Developmental Biology. 430(1):11-17
Hockman, D., Burns, A., Schlosser, G., Gates, K.P., Jevans, B., Mongera, A., Fisher, S., Unlu, G., Knapik, E.W., Kaufman, C.K., Mosimann, C., Zon, L.I., Lancman, J.J., Dong, P.D., Lickert, H., Tucker, A.S., Baker, C.V. (2017) Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. eLIFE. 6
Gays, D., Hess, C., Camporeale, A., Ala, U., Provero, P., Mosimann, C., Santoro, M.M. (2017) An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development (Cambridge, England). 144(3):464-478
Henninger, J., Santoso, B., Hans, S., Durand, E., Moore, J., Mosimann, C., Brand, M., Traver, D., Zon, L. (2017) Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nature cell biology. 19(1):17-27
Lindsay, H., Burger, A., Biyong, B., Felker, A., Hess, C., Zaugg, J., Chiavacci, E., Anders, C., Jinek, M., Mosimann, C., Robinson, M. D. (2016) CrispRVariants charts the mutation spectrum of genome engineering experiments. Nat. Biotechnol.. 34:701-702
Burger, A., Lindsay, H., Felker, A., Hess, C., Anders, C., Chiavacci, E., Zaugg, J., Weber, L.M., Catena, R., Jinek, M., Robinson, M.D., Mosimann, C. (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development (Cambridge, England). 143(11):2025-37
Felker, A., Nieuwenhuize, S., Dolbois, A., Blazkova, K., Hess, C., Low, L.W., Burger, S., Samson, N., Carney, T.J., Bartunek, P., Nevado, C., Mosimann, C. (2016) In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control. PLoS One. 11:e0152989
Kaufman, C.K., Mosimann, C., Fan, Z.P., Yang, S., Thomas, A.J., Ablain, J., Tan, J.L., Fogley, R.D., van Rooijen, E., Hagedorn, E.J., Ciarlo, C., White, R.M., Matos, D.A , Puller, A.C., Santoriello, C., Liao, E.C., Young, R.A., and Zon, L.I. (2016) A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science (New York, N.Y.). 351(6272):aad2197
Felker, A., Mosimann, C. (2016) Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments. Methods in cell biology. 135:219-44
Musso, G., Mosimann, C., Panáková, D., Burger, A., Zhou, Y., Zon, L.I., MacRae, C.A. (2015) Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genomics Data. 6:199-201
Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K., Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A., Zon, L.I. (2015) Chamber identity programs drive early functional partitioning of the heart. Nature communications. 6:8146
Briona, L.K., Poulain, F.E., Mosimann, C., Dorsky, R.I. (2015) Wnt/ß-catenin signaling Is required for radial glial neurogenesis following spinal cord injury. Developmental Biology. 403(1):15-21
Butko, E., Distel, M., Pouget, C., Weijts, B., Kobayashi, I., Ng, K., Mosimann, C., Poulain, F.E., McPherson, A., Ni, C.W., Stachura, D.L., Del Cid, N., Espín-Palazón, R., Lawson, N.D., Dorsky, R., Clements, W.K., Traver, D. (2015) Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England). 142:1050-61
Paardekooper Overman, J., Preisinger, C., Prummel, K., Bonetti, M., Giansanti, P., Heck, A., Hertog, J.D. (2014) Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome. PLoS One. 9:e106682
Musso, G., Tasan, M., Mosimann, C., Beaver, J.E., Plovie, E., Carr, L.A., Chua, H.N., Dunham, J., Zuberi, K., Rodriguez, H., Morris, Q., Zon, L., Roth, F.P., and MacRae, C.A. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (Cambridge, England). 141(1):224-235
Paik, E.J., Mahony, S., White, R.M., Price, E.N., Dibiase, A., Dorjsuren, B., Mosimann, C., Davidson, A.J., Gifford, D., and Zon, L.I. (2013) A cdx4-sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 1(5):425-436
Mosimann, C., Puller, A.C., Lawson, K.L., Tschopp, P., Amsterdam, A., and Zon, L.I. (2013) Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Developmental dynamics : an official publication of the American Association of Anatomists. 242(8):949-63
Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8
Mosimann, C., and Zon, L.I. (2011) Advanced Zebrafish Transgenesis with Tol2 and Application for Cre/lox Recombination Experiments. Methods in cell biology. 104:173-194
Mosimann, C., Kaufman, C.K., Li, P., Pugach, E.K., Tamplin, O.J., and Zon, L.I. (2011) Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development (Cambridge, England). 138(1):169-177