ZFIN Lab: Lin Lab

ZFIN ID: ZDB-LAB-130404-1

Lin Lab

PI/Director:	Lin, Fang
Contact Person:
Email:	fang-lin@uiowa.edu
URL:	http://www.anatomy.uiowa.edu/personnel.shtml?id=fanlin
Address:	Department of Anatomy & Cell Biology University of Iowa 1-404 Bowen Science Building 51 Newton Rd. Iowa City, IA 52242-1109
Country:	United States
Phone:	335 7749
Fax:	319 335 7198
Line Designation:	ui

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 14 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Ye, Ding Post-Doc

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188

Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918

Frommelt, J., Liu, E., Bhaidani, A., Hu, B., Gao, Y., Ye, D., Lin, F. (2023) Flat mount preparation for whole-mount fluorescent imaging of zebrafish embryos. Biology Open. 12(7):

He, M., Jiao, S., Zhang, R., Ye, D., Wang, H., Sun, Y. (2022) Translational control by maternal Nanog promotes oogenesis and early embryonic development. Development (Cambridge, England). 149(24):

Padhy, B., Xie, J., Wang, R., Lin, F., Huang, C.L. (2022) Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology : JASN. 33(8):1501-1516

Gao, Y., Hu, B., Flores, R., Xie, H., Lin, F. (2022) Fibronectin and Integrin α5 play overlapping and independent roles in regulating the development of pharyngeal endoderm and cartilage. Developmental Biology. 489:122-133

Mahabaleshwar, H., Asharani, P.V., Loo, T.Y., Koh, S.Y., Pitman, M.R., Kwok, S., Ma, J., Hu, B., Lin, F., Li Lok, X., Pitson, S.M., Saunders, T.E., Carney, T.J. (2022) Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports. 23(8):e54464

Kent, M.E., Hu, B., Eggleston, T.M., Squires, R.S., Zimmerman, K.A., Weiss, R.M., Roghair, R.D., Lin, F., Cornell, R.A., Haskell, S.E. (2022) Hypersensitivity of zebrafish htr2b mutant embryos to sertraline indicates a role for serotonin signaling in cardiac development. Journal of Cardiovascular Pharmacology. 80(2):261-269

Hu, B., Rodriguez, J.J., Kakkerla Balaraju, A., Gao, Y., Nguyen, N.T., Steen, H., Suhaib, S., Chen, S., Lin, F. (2021) Glypican 4 mediates Wnt transport between germ layers via signaling filopodia. The Journal of cell biology. 220(12):

Stark, B.C., Gao, Y., Sepich, D.S., Belk, L., Culver, M.A., Hu, B., Mekel, M., Ferris, W., Shin, J., Solnica-Krezel, L., Lin, F., Cooper, J.A. (2021) CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish. Developmental Biology. 481:148-159

Balaraju, A.K., Hu, B., Rodriguez, J.J., Murry, M., Lin, F. (2021) Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2. Development (Cambridge, England). 148(14):

Liu, C., Ye, D., Wang, H., He, M., Sun, Y. (2020) Elovl2 But Not Elovl5 Is Essential for the Biosynthesis of Docosahexaenoic Acid (DHA) in Zebrafish: Insight from a Comparative Gene Knockout Study. Marine biotechnology (New York, N.Y.). 22(5):613-619

He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561

Zhang, Q., Ye, D., Wang, H., Wang, Y., Sun, Y. (2020) Zebrafish cyp11c1 knockout reveals the roles of 11-ketotestosterone and cortisol in sexual development and reproduction. Endocrinology. 161(6):

Zhang, F., Li, X., He, M., Ye, D., Xiong, F., Amin, G., Zhu, Z., Sun, Y. (2020) Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells. Journal of genetics and genomics = Yi chuan xue bao. 47(1):37-47

Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., Sun, Y. (2019) Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLoS Genetics. 15:e1008306

Yang, X., Li, Y., Li, Y., Ye, D., Yuan, L., Sun, Y., Han, D., Hu, Q. (2019) Solid Matrix-Supported Supercritical CO₂ Enhances Extraction of γ-Linolenic Acid from the Cyanobacterium Arthrospira (Spirulina) platensis and Bioactivity Evaluation of the Molecule in Zebrafish. Marine drugs. 17(4):

Ye, D., Zhu, L., Zhang, Q., Xiong, F., Wang, H., Wang, X., He, M., Zhu, Z., Sun, Y. (2019) Abundance of Early Embryonic Primordial Germ Cells Promotes Zebrafish Female Differentiation as Revealed by Lifetime Labeling of Germline. Marine biotechnology (New York, N.Y.). 21(2):217-228

Hu, B., Gao, Y., Davies, L., Woo, S., Topczewski, J., Jessen, J.R., Lin, F. (2018) Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition. Development (Cambridge, England). 145(17):

Wang, X., Hou, H., Song, K., Zhang, Z., Zhang, S., Cao, Y., Chen, L., Sang, Q., Lin, F., Xu, H. (2018) Lpar2b Controls Lateral Line Tissue Size by Regulating Yap1 Activity in Zebrafish. Frontiers in molecular neuroscience. 11:34

Liu, Y., Xue, W., Zhu, L., Ye, D., Zhu, X., Wang, H., Sun, Y., Deng, F. (2017) Nanog suppresses the expression of vasa by directly regulating nlk1 in the early zebrafish embryo. Biochimie. 142:93-101

Ke, W., Ye, D., Mersch, K., Xu, H., Chen, S., Lin, F. (2017) Gβ1 is required for neutrophil migration in zebrafish. Developmental Biology. 428(1):135-147

Xie, H., Ye, D., Sepich, D., Lin, F. (2016) S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence. Developmental Biology. 414:228-43

Wang, H., Liu, Y., Ye, D., Li, J., Liu, J., Deng, F. (2016) Knockdown of zebrafish Nanog increases proliferation of primordial germ cells during early embryonic development. Development, growth & differentiation. 58(4):355-66

Ye, D., Xie, H., Hu, B., Lin, F. (2015) Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation. Development (Cambridge, England). 142:2928-40

Xu, H., Ye, D., Behra, M., Burgess, S., Chen, S., and Lin, F. (2014) Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Developmental Biology. 385(2):316-27

Jung, J.J., Inamdar, S.M., Tiwari, A., Ye, D., Lin, F., and Choudhury, A. (2013) Syntaxin 16 Regulates Lumen Formation during Epithelial Morphogenesis. PLoS One. 8(4):e61857

Ye, D., and Lin, F. (2013) S1pr2/Gα₁₃ signaling controls myocardial migration by regulating endoderm convergence. Development (Cambridge, England). 140(4):789-799

Xu, H., Kardash, E., Chen, S., Raz, E., and Lin, F. (2012) Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development (Cambridge, England). 139(1):57-62

Ye, D., Yang, Q., Li, Y., Huang, X., Hu, J., Qian, S., Tan, Z., and Song, P. (2011) G{alpha}(13) is closely related to hematopoiesis in zebrafish. Molecular biology reports. 38(4):2685-2694

Xu, H., Echemendia, N., Chen, S., and Lin, F. (2011) Identification and expression patterns of members of the protease-activated receptor (par) gene family during zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(1):278-287

Xu, Y., Wang, H., Zhou, J., Lei, Y., Zhou, Y., Yang, Q., Ye, D., Li, W., and Deng, F. (2010) Zebrafish Nanos interacts with and regulates the phosphorylation of Mylz2. Biochimie. 92(12):1812-1817

Speirs, C.K., Jernigan, K.K., Kim, S.H., Cha, Y.I., Lin, F., Sepich, D.S., DuBois, R.N., Lee, E., and Solnica-Krezel, L. (2010) Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development (Cambridge, England). 137(8):1327-1337

Yang, Q., Hu, J., Ye, D., Zhao, C., Song, S., Gong, W., Tan, Z., and Song, P. (2010) Identification and expression analysis of two zebrafish E2F5 genes during oogenesis and development. Molecular biology reports. 37(4):1773-1780

Lin, F., Chen, S., Sepich, D.S., Panizzi, J.R., Clendenon, S.G., Marrs, J.A., Hamm, H.E., and Solnica-Krezel, L. (2009) Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. The Journal of cell biology. 184(6):909-921

Lin, F., Sepich, D.S., Chen, S., Topczewski, J., Yin, C., Solnica-Krezel, L., and Hamm, H. (2005) Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. The Journal of cell biology. 169(5):777-787