ZFIN ID: ZDB-LAB-130307-1
Yi Feng Lab
PI/Director: Feng, Yi
Contact Person: Feng, Yi
Email: yi.feng@ed.ac.uk
URL: http://www.cir.ed.ac.uk/investigator/Dr-Yi-Feng
Address: MRC Centre for Inflammation Research Queen's Medical Research Institute University of Edinburgh 47 Little France Crescent Edinburgh EH16 4TJ
Country: France
Phone: + 44 131 242 6685
Fax: +44 131 242 6578
Line Designation: ed


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
My lab interested in mechanisms that maintain Tissue Homeostasis, and their relevance to the ""Cancer Problem"". Inflammation may function physiologically to restore disturbed tissue homeostasis; while subclinical inflammation underlines many chronic diseases including cancer. I discovered that an emerging transformed-cell triggers a tumour promoting TROPHIC inflammation response. My aim is to unravel its underlying mechanisms using a zebrafish model and in vivo live imaging approaches.","In my studies I generate a large volume of in vivo live imaging time sequence data on leukocyte migrating behaviour. One of my interests is to use computational methods to model leukocyte behaviour in various tissue environments, and which might help to predict novel signals that would modulate leukocyte behavior in a hitherto novel environment.


LAB MEMBERS
Laux, Derek W. Post-Doc Ramezani, Thomas Post-Doc Chang, Ziyuan (Elva) Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Benson, S., de Moliner, F., Fernandez, A., Kuru, E., Asiimwe, N.L., Lee, J.S., Hamilton, L., Sieger, D., Bravo, I.R., Elliot, A.M., Feng, Y., Vendrell, M. (2021) Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo. Nature communications. 12:2369
Campbell, J.S., Davidson, A.J., Todd, H., Rodrigues, F.S.L.M., Elliot, A.M., Early, J.J., Lyons, D.A., Feng, Y., Wood, W. (2020) PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo. Current biology : CB. 31(4):875-883.e5
Elliot, A., Myllymäki, H., Feng, Y. (2020) Inflammatory Responses during Tumour Initiation: From Zebrafish Transgenic Models of Cancer to Evidence from Mouse and Man. Cells. 9(4)
van den Berg, M.C.W., MacCarthy-Morrogh, L., Carter, D., Morris, J., Ribeiro Bravo, I., Feng, Y., Martin, P. (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Reports. 27:2837-2846.e4
Zhu, C., Guo, Z., Zhang, Y., Liu, M., Chen, B., Cao, K., Wu, Y., Yang, M., Yin, W., Zhao, H., Tai, H., Ou, Y., Yu, X., Liu, C., Li, S., Su, B., Feng, Y., Huang, S. (2019) Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms. International journal of biological sciences. 15:1225-1239
Dickmeis, T., Feng, Y., Mione, M.C., Ninov, N., Santoro, M., Spaink, H.P., Gut, P. (2019) Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in cell and developmental biology. 7:15
Rausch, V., Bostrom, J.R., Park, J., Bravo, I.R., Feng, Y., Hay, D.C., Link, B.A., Hansen, C.G. (2018) The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. Current biology : CB. 29(2):242-255.e6
Tsarouchas, T.M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N., Feng, Y., van Ham, T.J., Becker, T., Becker, C.G. (2018) Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration. Nature communications. 9:4670
Loynes, C.A., Lee, J.A., Robertson, A.L., Steel, M.J., Ellett, F., Feng, Y., Levy, B.D., Whyte, M.K.B., Renshaw, S.A. (2018) PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.. Science advances. 4:eaar8320
Ogryzko, N., Feng, Y. (2018) Helping hand for melanoma invasion: transparent zebrafish can catch macrophages in the act. Pigment cell & melanoma research. 31(4):459-460
Campana, L., Starkey Lewis, P.J., Pellicoro, A., Aucott, R.L., Man, J., O'Duibhir, E., Mok, S.E., Ferreira-Gonzalez, S., Livingstone, E., Greenhalgh, S.N., Hull, K.L., Kendall, T.J., Vernimmen, D., Henderson, N.C., Boulter, L., Gregory, C.D., Feng, Y., Anderton, S.M., Forbes, S.J., Iredale, J.P. (2018) The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury. Journal of immunology (Baltimore, Md. : 1950). 200:1169-1187
Lessel, D., Wu, D., Trujillo, C., Ramezani, T., Lessel, I., Alwasiyah, M.K., Saha, B., Hisama, F.M., Rading, K., Goebel, I., Schütz, P., Speit, G., Högel, J., Thiele, H., Nürnberg, G., Nürnberg, P., Hammerschmidt, M., Zhu, Y., Tong, D.R., Katz, C., Martin, G.M., Oshima, J., Prives, C., Kubisch, C. (2017) Dysfunction of the MDM2/p53 axis is linked to premature aging. The Journal of Clinical Investigation. 127(10):3598-3608
Laux, D.W., Kelly, L., Bravo, I.R., Ramezani, T., Feng, Y. (2017) Live imaging the earliest host innate immune response to preneoplastic cells using a zebrafish inducible KalTA4-ERT2/UAS system.. Methods in cell biology. 138:137-150
Richardson, R., Metzger, M., Knyphausen, P., Ramezani, T., Slanchev, K., Kraus, C., Schmelzer, E., Hammerschmidt, M. (2016) Re-epithelialization of cutaneous wounds in adult zebrafish uses a combination of mechanisms at play during wound closure in embryonic and adult mammals. Development (Cambridge, England). 143(12):2077-88
Feng, Y., Santoriello, C., Mione, M., Hurlstone, A., Martin, P. (2016) Correction: Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation. PLoS Biology. 14:e1002377
Antonio, N., Bønnelykke-Behrndtz, M.L., Ward, L.C., Collin, J., Christensen, I.J., Steiniche, T., Schmidt, H., Feng, Y., Martin, P. (2015) The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer. The EMBO journal. 34(17):2219-36
Feng, Y., Martin, P. (2015) Imaging innate immune responses at tumour initiation: new insights from fish and flies. Nature reviews. Cancer. 15(9):556-62
Yan, C., Huo, X., Wang, S., Feng, Y., Gong, Z. (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. Journal of hepatology. 63(2):420-8
Deng, C., Chen, H., Yang, N., Feng, Y., Hsueh, A.J. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. The Journal of biological chemistry. 290(30):18261-8
Ramezani, T., Laux, D.W., Bravo, I.R., Tada, M., Feng, Y. (2015) Live Imaging of Innate Immune and Preneoplastic Cell Interactions Using an Inducible Gal4/UAS Expression System in Larval Zebrafish Skin. Journal of visualized experiments : JoVE. (96)
Williamson, R.C., Cowell, C.A., Hammond, C.L., Bergen, D., Roper, J., Feng, Y., Rendall, T.C., Race, P.R., Bass, M.D. (2014) Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. Journal of Cell Science. 127(Pt 19):4292-307
Fischer, B., Metzger, M., Richardson, R., Knyphausen, P., Ramezani, T., Franzen, R., Schmelzer, E., Bloch, W., Carney, T.J., and Hammerschmidt, M. (2014) p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genetics. 10(1):e1004048
Jones, R.A., Feng, Y., Worth, A.J., Thrasher, A.J., Burns, S.O., and Martin, P. (2013) Modelling human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using live in vivo imaging. Journal of Cell Science. 126(Pt 18):4077-84
Schmidt, K., Cavodeassi, F., Feng, Y., and Stephens, D.J. (2013) Early stages of retinal development depend on Sec13 function. Biology Open. 2(3):256-266
Lévesque, M., Feng, Y., Jones, R., and Martin, P. (2013) Inflammation drives wound hyperpigmentation by recruiting pigment cells to sites of tissue damage. Disease models & mechanisms. 6(2):508-515
Feng, Y., Renshaw, S., and Martin, P. (2012) Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE(2). Current biology : CB. 22(13):1253-1259
Williams, C.M., Feng, Y., Martin, P., and Poole, A.W. (2011) Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis. Journal of thrombosis and haemostasis : JTH. 9(12):2457-65
Feng, Y., Santoriello, C., Mione, M., Hurlstone, A., and Martin, P. (2010) Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation. PLoS Biology. 8(12):e1000562
Feng, Y., and Xu, Q. (2010) Pivotal role of hmx2 and hmx3 in zebrafish inner ear and lateral line development. Developmental Biology. 339(2):507-518
Townley, A.K., Feng, Y., Schmidt, K., Carter, D.A., Porter, R., Verkade, P., and Stephens, D.J. (2008) Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. Journal of Cell Science. 121(Pt 18):3025-3034