ZFIN ID: ZDB-LAB-130102-1
Varga Lab
PI/Director: Varga, Máté
Contact Person: Varga, Máté
Email: mvarga@ttk.elte.hu
URL: http://danio.elte.hu/index.html
Address: ELTE Eötvös Loránd University, Department of Genetics, Pázmány Péter stny. 1/C, H-1117 Budapest, Hungary
Country: Hungary
Phone: 00(36)1-372 2500/8701
Fax:
Line Designation: elu


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 7 genomic features


STATEMENT OF RESEARCH INTERESTS
The main focus of my group is the modelling of different rare, monogenic human diseases using zebrafish. We are especially interested in diseases linked to pseudouridylation defects and diseases resulting from the dysfunction of RecQ helicase orthologs.

Lately we also became interested in working with paradise fish as a model for evodevo and behavioral genetics.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Méhes, E., Mones, E., Varga, M., Zsigmond, Á., Biri-Kovács, B., Nyitray, L., Barone, V., Krens, G., Heisenberg, C.P., Vicsek, T. (2023) 3D cell segregation geometry and dynamics are governed by tissue surface tension regulation. Communications biology. 6:817817
Maruf, A., Milewska, M., Kovács, T., Varga, M., Vellai, T., Lalik, A., Student, S., Borges, O., Wandzik, I. (2022) Trehalose-releasing nanogels: A step toward a trehalose delivery vehicle for autophagy stimulation. Biomaterials advances. 138:212969
Annus, T., Müller, D., Jezsó, B., Ullaga, G., Németh, B., Harami, G.M., Orbán, L., Kovács, M., Varga, M. (2022) Bloom syndrome helicase contributes to germ line development and longevity in zebrafish. Cell Death & Disease. 13:363
Csabai, L., Fazekas, D., Kadlecsik, T., Szalay-Bekő, M., Bohár, B., Madgwick, M., Módos, D., Ölbei, M., Gul, L., Sudhakar, P., Kubisch, J., Oyeyemi, O.J., Liska, O., Ari, E., Hotzi, B., Billes, V.A., Molnár, E., Földvári-Nagy, L., Csályi, K., Demeter, A., Pápai, N., Koltai, M., Varga, M., Lenti, K., Farkas, I.J., Türei, D., Csermely, P., Vellai, T., Korcsmáros, T. (2021) SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks. Nucleic acids research. 50(D1):D701-D709
Cerveny, K.L., Bronstein, H., Hagen, O., Lamb, D.B., Martin, G., Tower, I., Van Duzer, A., Welch, E., Varga, M. (2021) Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. microPublication. Biology. 2021:
Bátora, D., Zsigmond, Á., Lőrincz, I.Z., Szegvári, G., Varga, M., Málnási-Csizmadia, A. (2021) Subcellular Dissection of a Simple Neural Circuit: Functional Domains of the Mauthner-Cell During Habituation. Frontiers in neural circuits. 15:648487
Rácz, A., Adorján, G., Fodor, E., Sellyei, B., Tolba, M., Miklósi, Á., Varga, M. (2021) Housing, Husbandry and Welfare of a "Classic" Fish Model, the Paradise Fish (Macropodus opercularis). Animals : an open access journal from MDPI. 11(3):
Czimer, D., Porok, K., Csete, D., Gyüre, Z., Lavró, V., Fülöp, K., Chen, Z., Gyergyák, H., Tusnády, G.E., Burgess, S.M., Mócsai, A., Váradi, A., Varga, M. (2021) A New Zebrafish Model for Pseudoxanthoma Elasticum. Frontiers in cell and developmental biology. 9:628699
Balogh, E., Chandler, J.C., Varga, M., Tahoun, M., Menyhárd, D.K., Schay, G., Goncalves, T., Hamar, R., Légrádi, R., Szekeres, Á., Gribouval, O., Kleta, R., Stanescu, H., Bockenhauer, D., Kerti, A., Williams, H., Kinsler, V., Di, W.L., Curtis, D., Kolatsi-Joannou, M., Hammid, H., Szőcs, A., Perczel, K., Maka, E., Toldi, G., Sava, F., Arrondel, C., Kardos, M., Fintha, A., Hossain, A., D'Arco, F., Kaliakatsos, M., Koeglmeier, J., Mifsud, W., Moosajee, M., Faro, A., Jávorszky, E., Rudas, G., Saied, M.H., Marzouk, S., Kelen, K., Götze, J., Reusz, G., Tulassay, T., Dragon, F., Mollet, G., Motameny, S., Thiele, H., Dorval, G., Nürnberg, P., Perczel, A., Szabó, A.J., Long, D.A., Tomita, K., Antignac, C., Waters, A.M., Tory, K. (2020) Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis. Proceedings of the National Academy of Sciences of the United States of America. 117(26):15137-15147
Varga, M., Csályi, K., Bertyák, I., Menyhárd, D.K., Poole, R.J., Cerveny, K.L., Kövesdi, D., Barátki, B., Rouse, H., Vad, Z., Hawkins, T.A., Stickney, H.L., Cavodeassi, F., Schwarz, Q., Young, R.M., Wilson, S.W. (2020) Tissue-Specific Requirement for the GINS Complex During Zebrafish Development. Frontiers in cell and developmental biology. 8:373
Varga, Z.K., Pejtsik, D., Biró, L., Zsigmond, Á., Varga, M., Tóth, B., Salamon, V., Annus, T., Mikics, É., Aliczki, M. (2020) Conserved serotonergic background of experience-dependent behavioral responsiveness in zebrafish (Danio rerio). The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(23):4551-4564
Cayuela, M.L., Claes, K.B.M., Ferreira, M.G., Henriques, C.M., van Eeden, F., Varga, M., Vierstraete, J., Mione, M.C. (2019) The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases. Frontiers in cell and developmental biology. 6:178
Varga, Z.K., Zsigmond, Á., Pejtsik, D., Varga, M., Demeter, K., Mikics, É., Haller, J., Aliczki, M. (2018) The swimming plus-maze test: a novel high-throughput model for assessment of anxiety-related behaviour in larval and juvenile zebrafish (Danio rerio). Scientific Reports. 8:16590
Varga, M., Ralbovszki, D., Balogh, E., Hamar, R., Keszthelyi, M., Tory, K. (2018) Zebrafish Models of Rare Hereditary Pediatric Diseases. Diseases (Basel, Switzerland). 6(2)
Varga, M. (2018) The Doctor of Delayed Publications: The Remarkable Life of George Streisinger (1927-1984). Zebrafish. 15(3):314-319
Fodor, E., Sigmond, T., Ari, E., Lengyel, K., Takács-Vellai, K., Varga, M., Vellai, T. (2017) Methods to Study Autophagy in Zebrafish. Methods in enzymology. 588:467-496
Csályi, K., Fazekas, D., Kadlecsik, T., Türei, D., Gul, L., Horváth, B., Módos, D., Demeter, A., Pápai, N., Lenti, K., Csermely, P., Vellai, T., Korcsmáros, T., Varga, M. (2016) SignaFish: A Zebrafish-Specific Signaling Pathway Resource. Zebrafish. 13(6):541-544
Várkuti, B.H., Képiró, M., Horváth, I.Á., Végner, L., Ráti, S., Zsigmond, Á., Hegyi, G., Lenkei, Z., Varga, M., Málnási-Csizmadia, A. (2016) A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Scientific Reports. 6:26141
Papp, D., Kovács, T., Billes, V., Varga, M., Tarnóci, A., Hackler, L., Puskás, L.G., Liliom, H., Tárnok, K., Schlett, K., Borsy, A., Pádár, Z., Kovács, A.L., Hegedűs, K., Juhász, G., Komlós, M., Erdős, A., Gulyás, B., Vellai, T. (2016) AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. Autophagy. 12:273-86
Képiró, M., Várkuti, B.H., Rauscher, A.A., Kellermayer, M.S., Varga, M., Málnási-Csizmadia, A. (2015) Molecular Tattoo: Subcellular Confinement of Drug Effects. Chemistry & Biology. 22(4):548-58
Varga, M., Fodor, E., Vellai, T. (2015) Autophagy in zebrafish. Methods (San Diego, Calif.). 75:172-80
Varga, M., Sass, M., Papp, D., Takács-Vellai, K., Kobolak, J., Dinnyés, A., Klionsky, D.J., and Vellai, T. (2014) Autophagy is required for zebrafish caudal fin regeneration. Cell death and differentiation. 21(4):547-56
Fodor, E., Zsigmond, A., Horváth, B., Molnár, J., Nagy, I., Tóth, G., Wilson, S.W., and Varga, M. (2013) Full transcriptome analysis of early dorsoventral patterning in zebrafish. PLoS One. 8(7):e70053
Varga, M., Maegawa, S., and Weinberg, E.S. (2011) Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer. BMC Developmental Biology. 11(1):26
Varga, M., Maegawa, S., Bellipanni, G., and Weinberg, E.S. (2007) Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo. Mechanisms of Development. 124(9-10):775-791
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