ZFIN ID: ZDB-LAB-121017-1
Maves Lab
PI/Director: Maves, Lisa
Contact Person: Maves, Lisa
Email: lmaves@u.washington.edu
Address: Seattle Children's Research Institute 1900 Ninth Avenue, C9S-5 Seattle, WA, 98101 USA
Country: United States
Phone: 206-884-1426
Fax: 206-884-1407
Line Designation: scm

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Our lab studies how homeodomain transcription factors regulate differentiation of skeletal muscle and cardiac muscle cells. In particular, we focus on the functions of Pbx and Meis proteins. Our goal is to understand how subsets of gene expression during the muscle differentiation process are controlled. We aim to use this understanding to manipulate muscle differentiation and work toward potential therapies for muscle diseases.

Farr III, G. Hank Research Staff Johnson, Nathan Research Staff

Farr, G.H., Morris, M., Gomez, A., Pham, T., Kilroy, E., Parker, E.U., Said, S., Henry, C., Maves, L. (2020) A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skeletal muscle. 10:29
Maves, L. (2020) Special Issue "Zebrafish-A Model System for Developmental Biology Study". Journal of developmental biology. 8(3)
Farr, G.H., Imani, K., Pouv, D., Maves, L. (2018) Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects.. Disease models & mechanisms. 11(10):
Row, R.H., Pegg, A., Kinney, B., Farr, G.H., Maves, L., Lowell, S., Wilson, V., Martin, B.L. (2018) BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. eLIFE. 7
Patton, C., Farr, G.H., An, D., Martini, P.G.V., Maves, L. (2018) Lipid Nanoparticle Packaging Is an Effective and Nontoxic mRNA Delivery Platform in Embryonic Zebrafish. Zebrafish. 15(3):217-227
Goody, M.F., Carter, E.V., Kilroy, E.A., Maves, L., Henry, C.A. (2017) "Muscling" Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish. Current topics in developmental biology. 124:197-234
Yates, A., Akanni, W., Amode, M.R., Barrell, D., Billis, K., Carvalho-Silva, D., Cummins, C., Clapham, P., Fitzgerald, S., Gil, L., Girón, C.G., Gordon, L., Hourlier, T., Hunt, S.E., Janacek, S.H., Johnson, N., Juettemann, T., Keenan, S., Lavidas, I., Martin, F.J., Maurel, T., McLaren, W., Murphy, D.N., Nag, R., Nuhn, M., Parker, A., Patricio, M., Pignatelli, M., Rahtz, M., Riat, H.S., Sheppard, D., Taylor, K., Thormann, A., Vullo, A., Wilder, S.P., Zadissa, A., Birney, E., Harrow, J., Muffato, M., Perry, E., Ruffier, M., Spudich, G., Trevanion, S.J., Cunningham, F., Aken, B.L., Zerbino, D.R., Flicek, P. (2016) Ensembl 2016. Nucleic acids research. 44(D1):D710-6
Bouldin, C.M., Manning, A.J., Peng, Y.H., Farr, G.H., Hung, K.L., Dong, A., Kimelman, D. (2015) Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development (Cambridge, England). 142:2499-507
Kao, R.M., Rurik, J.G., Farr, G.H., Dong, X.R., Majesky, M.W., Maves, L. (2015) Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation. Journal of developmental biology. 3:93-111
Maves, L. (2014) Recent advances using zebrafish animal models for muscle disease drug discovery. Expert opinion on drug discovery. 9(9):1033-45
Smith, J.D., Hing, A.V., Clarke, C.M., Johnson, N.M., Perez, F.A., Park, S.S., Horst, J.A., Mecham, B., Maves, L., Nickerson, D.A., University of Washington Center for Mendelian Genomics, Cunningham, M.L. (2014) Exome Sequencing Identifies a Recurrent De Novo ZSWIM6 Mutation Associated with Acromelic Frontonasal Dysostosis. American journal of human genetics. 95:235-240
Bouldin, C.M., Snelson, C.D., Farr, G.H. 3rd, and Kimelman, D. (2014) Restricted expression of cdc25a in the tailbud is essential for formation of the zebrafish posterior body. Genes & Development. 28(4):384-95
Johnson, N.M., Farr, G.H., and Maves, L. (2013) The HDAC Inhibitor TSA Ameliorates a Zebrafish Model of Duchenne Muscular Dystrophy. PLoS Currents. 5:157-71
Yao, Z., Farr, G.H., Tapscott, S.J., and Maves, L. (2013) Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish. Biology Open. 2(6):546-555
Flicek, P., Ahmed, I., Amode, M.R., Barrell, D., Beal, K., Brent, S., Carvalho-Silva, D., Clapham, P., Coates, G., Fairley, S., Fitzgerald, S., Gil, L., García-Girón, C., Gordon, L., Hourlier, T., Hunt, S., Juettemann, T., Kähäri, A.K., Keenan, S., Komorowska, M., Kulesha, E., Longden, I., Maurel, T., McLaren, W.M., Muffato, M., Nag, R., Overduin, B., Pignatelli, M., Pritchard, B., Pritchard, E., Riat, H.S., Ritchie, G.R., Ruffier, M., Schuster, M., Sheppard, D., Sobral, D., Taylor, K., Thormann, A., Trevanion, S., White, S., Wilder, S.P., Aken, B.L., Birney, E., Cunningham, F., Dunham, I., Harrow, J., Herrero, J., Hubbard, T.J., Johnson, N., Kinsella, R., Parker, A., Spudich, G., Yates, A., Zadissa, A., and Searle, S.M. (2013) Ensembl 2013. Nucleic acids research. 41(D1):D48-55
Paige, S.L., Thomas, S., Stoick-Cooper, C.L., Wang, H., Maves, L., Sandstrom, R., Pabon, L., Reinecke, H., Pratt, G., Keller, G., Moon, R.T., Stamatoyannopoulos, J., and Murry, C.E. (2012) A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development. Cell. 151(1):221-232
Maves, L., Tyler, A., Moens, C.B., and Tapscott, S.J. (2009) Pbx acts with Hand2 in early myocardial differentiation. Developmental Biology. 333(2):409-418
Sittaramane, V., Sawant, A., Wolman, M.A., Maves, L., Halloran, M.C., and Chandrasekhar, A. (2009) The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Developmental Biology. 325(2):363-373
Maves, L., Waskiewicz, A.J., Paul, B., Cao, Y., Tyler, A., Moens, C.B., and Tapscott, S.J. (2007) Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation. Development (Cambridge, England). 134(18):3371-3382
Maves, L., and Kimmel, C.B. (2005) Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Developmental Biology. 285(2):593-605
Crump, J.G., Maves, L., Lawson, N.D., Weinstein, B.M., and Kimmel, C.B. (2004) An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development (Cambridge, England). 131(22):5703-5716
Miller, C.T., Maves, L., and Kimmel, C.B. (2004) moz regulates Hox expression and pharyngeal segmental identity in zebrafish. Development (Cambridge, England). 131(10):2443-2461
Liu, D., Chu, H., Maves, L., Yan, Y.-L., Morcos, P.A., Postlethwait, J.H., and Westerfield, M. (2003) Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development (Cambridge, England). 130(10):2213-2224
Maves, L., Jackman, W., and Kimmel, C.B. (2002) FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Development (Cambridge, England). 129:3825-3837
Maves, L. and Kimmel, C.B. (2002) Dual roles for FGF signaling in promoting zebrafish hindbrain development. Developmental Biology. 247(2):480-481