ZFIN Lab: Gui Lab

ZFIN ID: ZDB-LAB-111031-1

Gui Lab

PI/Director:	Gui, Jian-Fang
Co-PI / Senior Researcher:	Zhou, Li
Contact Person:	Gui, Jian-Fang
Email:	jfgui@ihb.ac.cn
URL:	http://sourcedb.cas.cn/sourcedb_ihb_cas/en/expert/pl/200907/t20090722_2156224.html
Address:	No. 7 Donghu South Road, Wuchang District, Wuhan, Hubei Province, P.R.China
Country:	China
Phone:	86-027-68780707
Fax:
Line Designation:	ihb

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 30 genomic features

STATEMENT OF RESEARCH INTERESTS

1. Developmental Genetics: The scientific objectives are to identify reproduction-, and growth- related genes, and thereby to reveal regulation mechanisms on fish gynogenesis and oogenesis, and to investigate temporal and spatial control of gene expression in fish early embryogenesis.

2. Immunological Genetics: The scientific objective is to identify immune-related genes, especially the innate immunity-related genes, and thereby to identify disease-resistant genes and to reveal immunological mechanisms on disease prevention and cure in fish.

3. Fish Genetic Breeding: This study field is looking forward to molecular markers for discriminating different populations or strains, and is trying to apply them to the studies on ecological genetics and selective breeding in aquaculture animals. In addition, the Laboratory is devoted to cell engineering technology in fish, such as genome manipulation, cell fate tracing, and gene knockdown. The target species include gibel carp (Carassius auratus gibelio), goldfish (Carassius auratus), and grouper (Epinephelus coioides), as well as model fish zebrafish (Danio rerio).

LAB MEMBERS

Wang, Yang	Wang, Zhong-Wei	Wei, Li-Hua
Zhang, Xiao-juan

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Zhao, X., An, L.-.L., Gong, X.-.Y., Dan, C., Qu, Z.-.L., Sun, H.-.Y., Guo, W.-.H., Gui, J.-.F., Zhang, Y.-.B. (2024) A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING. Journal of virology. 98(2):e0180123

Yan, C., Yang, Q., Huo, X., Li, H., Zhou, L., Gong, Z. (2023) Retraction Note: Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Scientific Reports. 13:2103121031

Lu, L.-.F., Li, Z.-.C., Zhang, C., Chen, D.-.D., Han, K.-.J., Zhou, X.-.Y., Wang, X.-.L., Li, X.-.Y., Zhou, L., Li, S. (2023) Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection. Journal of virology. 97(11):e0143423

Deng, S., Guo, A., Huang, Z., Guan, K., Zhu, Y., Chan, C., Gui, J., Song, C., Li, X. (2023) The exploration of neuroinflammatory mechanism by which CRHR2 deficiency induced anxiety disorder. Progress in neuro-psychopharmacology & biological psychiatry. 128:110844

Peng, F., Zhou, L., Lu, W., Gan, R., Lu, M., Li, Z., Zhang, X., Wang, Y., Gui, J. (2023) Genomic and Transcriptional Profiles of Kelch-like (klhl) Gene Family in Polyploid Carassius Complex. International Journal of Molecular Sciences. 24(9):

Li, Y.L., Gong, X.Y., Qu, Z.L., Zhao, X., Dan, C., Sun, H.Y., An, L.L., Gui, J.F., Zhang, Y.B. (2023) Zebrafish HERC7c Acts as an Inhibitor of Fish IFN Response. International Journal of Molecular Sciences. 24(5):

Li, Z.C., Lu, L.F., Zhang, C., Wang, X.L., Tong, J.F., Han, K.J., Chen, D.D., Li, X.Y., Zhou, L., Gui, J.F., Li, S. (2022) GCRV NS38 counteracts SVCV proliferation by intracellular antagonization during co-infection. Virologica Sinica. 38(1):142-156

Zhou, J., Yang, Y.J., Gan, R.H., Wang, Y., Li, Z., Zhang, X.J., Gui, J.F., Zhou, L. (2022) Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish. Gene expression patterns : GEP. 46:119286

Gong, X.Y., Qu, Z.L., Li, Y.L., Sun, H.Y., Zhao, X., Dan, C., Gui, J.F., Zhang, Y.B. (2022) Function conservation and disparities of zebrafish and human LGP2 genes in fish and mammalian cells responsive to poly(I:C). Frontiers in immunology. 13:985792

Gong, X.Y., Zhang, Q.M., Zhao, X., Li, Y.L., Qu, Z.L., Li, Z., Dan, C., Gui, J.F., Zhang, Y.B. (2022) LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 25:104821

Zhao, X., Dan, C., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., An, L.L., Guo, W.H., Gui, J.F., Zhang, Y.B. (2022) Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Developmental and comparative immunology. 135:104485

Lu, L.F., Jiang, J.Y., Du, W.X., Wang, X.L., Li, Z.C., Zhou, X.Y., Zhang, C., Mou, C.Y., Chen, D.D., Li, Z., Zhou, L., Gui, J.F., Li, X.Y., Li, S. (2022) Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA. PLoS pathogens. 18:e1010626

An, L.L., Zhao, X., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., Guo, W.H., Dan, C., Gui, J.F., Zhang, Y.B. (2022) Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response. Frontiers in immunology. 13:861262

Zhang, T., Guan, P., Liu, W., Zhao, G., Fang, Y., Fu, H., Gui, J.F., Li, G., Liu, J.X. (2020) Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms. 1863(10):194612

Xiong, S., Tian, J., Ge, S., Li, Z., Long, Z., Guo, W., Huang, P., He, Y., Xiao, T., Gui, J.F., Mei, J. (2020) The miRNA-200 cluster on chromosome 23 is required for oocyte maturation and ovulation in zebrafish. Biology of reproduction. 103(4):769-778

Ren, F., Lin, Q., Gong, G., Du, X., Dan, H., Qin, W., Miao, R., Xiong, Y., Xiao, R., Li, X., Gui, J.F., Mei, J. (2020) Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish. Communications biology. 3:94

Wang, C., Chen, Y., Wang, Y., Liu, X., Liu, Y., Li, Y., Chen, H., Fan, C., Wu, D., Yang, J. (2019) Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1. Journal of experimental & clinical cancer research : CR. 38:371

Shi, C., Lu, Y., Zhai, G., Huang, J., Shang, G., Lou, Q., Li, D., Jin, X., He, J., Du, Z., Gui, J., Yin, Z. (2019) Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of molecular cell biology. 12(4):291-304

Wang, Y., Wang, Z.G., Song, X.Q., Chen, Q., Tian, H., Xie, C.Z., Li, Q.Z., Xu, J.Y. (2019) A dual functional turn-on non-toxic chemosensor for highly selective and sensitive visual detection of Mg²⁺ and Zn²⁺: the solvent-controlled recognition effect and bio-imaging application. The Analyst. 144(13):4024-4032

He, W.X., Wu, M., Liu, Z., Li, Z., Wang, Y., Zhou, J., Yu, P., Zhang, X.J., Zhou, L., Gui, J.F. (2018) Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis. RNA (New York, N.Y.). 24(12):1738-1748

Sun, W., Yan, B., Wang, R., Liu, F., Hu, Z., Zhou, L., Yan, L., Zhou, K., Huang, J., Tong, P., Shan, L., Efferth, T. (2018) In vivo acute toxicity of detoxified Fuzi (lateral root of Aconitum carmichaeli) after a traditional detoxification process. EXCLI journal. 17:889-899

Huang, P., Xiong, S., Kang, J., Mei, J., Gui, J.F. (2018) Stat5b Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver.. Frontiers in Physiology. 9:676

Xiong, S., Ma, W., Jing, J., Zhang, J., Dan, C., Gui, J.F., Mei, J. (2018) An miR-200 cluster on chromosome 23 regulates sperm motility in zebrafish. Endocrinology. 159(5):1982-1991

Yu, G., Zhang, D., Liu, W., Wang, J., Liu, X., Zhou, C., Gui, J., Xiao, W. (2018) Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function. Oncotarget. 9:24320-24334

Zhou, L., Feng, Y., Wang, F., Dong, X., Jiang, L., Liu, C., Zhao, Q., Li, K. (2018) Generation of all-male-like sterile zebrafish by eliminating primordial germ cells at early development. Scientific Reports. 8:1834

Guo, W., Xie, B., Xiong, S., Liang, X., Gui, J.F., Mei, J. (2017) miR-34a Regulates Sperm Motility in Zebrafish. International Journal of Molecular Sciences. 18(12)

Zhang, J., Zhang, X., Liu, Y., Su, Z., Dawar, F.U., Dan, H., He, Y., Gui, J.F., Mei, J. (2017) Leucine mediates autophagosome-lysosome fusion and improves sperm motility by activating the PI3K/Akt pathway. Oncotarget. 8:111807-111818

Zhang, Q.M., Zhao, X., Li, Z., Wu, M., Gui, J.F., Zhang, Y.B. (2017) Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response. Journal of immunology (Baltimore, Md. : 1950). 200(2):688-703

Xiong, S., Mei, J., Huang, P., Jing, J., Li, Z., Kang, J., Gui, J.F. (2017) Essential roles of stat5.1/stat5b in controlling fish somatic growth. Journal of genetics and genomics = Yi chuan xue bao. 44(12):577-585

Lin, Q., Mei, J., Li, Z., Zhang, X., Zhou, L., Gui, J.F. (2017) Distinct and Cooperative Roles of amh and dmrt1 in Self-Renewal and Differentiation of Male Germ Cells in Zebrafish.. Genetics. 207(3):1007-1022

Huang, W., Yang, P., Lv, Z., Wu, C., Gui, J., Lou, B. (2017) Cloning, expression pattern and promoter functional analysis of cyp19a1a gene in miiuy croaker. Gene. 627:271-277

Li, S.Z., Liu, W., Li, Z., Li, W.H., Wang, Y., Zhou, L., Gui, J.F. (2017) greb1 regulates convergent extension movement and pituitary development in zebrafish. Gene. 627:176-187

Sun, Z.H., Zhou, L., Li, Z., Liu, X.C., Li, S.S., Wang, Y., Gui, J.F. (2017) Sexual dimorphic expression of dnd in germ cells during sex reversal and its requirement for primordial germ cell survival in protogynous hermaphroditic grouper. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 208-209:47-57

Yan, C., Yang, Q., Huo, X., Li, H., Zhou, L., Gong, Z. (2017) RETRACTED: Chemical inhibition reveals differential requirements of signaling pathways in kras^V12- and Myc-induced liver tumors in transgenic zebrafish.. Scientific Reports. 7:45796

Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572

Xiong, S., Wu, J, Jing, J., Huang, P., Li, Z., Mei, J., Gui, J.F, (2017) Loss of stat3 function leads to spine malformation and immune disorder in zebrafish. Science Bulletin. 62:Pages 185-196

Jing, J., Xiong, S., Li, Z., Wu, J., Zhou, L., Gui, J.F., Mei, J. (2015) A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish. Scientific Reports. 5:15906

Li, W.H., Zhou, L., Li, Z., Wang, Y., Shi, J.T., Yang, Y.J., Gui, J.F. (2015) Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. International journal of biological sciences. 11(6):688-700

Mei, J., Gui, J.F. (2015) Genetic basis and biotechnological manipulation of sexual dimorphism and sex determination in fish.. Science China. Life sciences. 58(2):124-36

Wang, Y., Li, W.H., Li, Z., Liu, W., Zhou, L., Gui, J.F. (2015) BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development. Gene. 554:196-204

Chen, T., Zhou, L., Yuan, Y., Fang, Y., Guo, Y., Huang, H., Zhou, Q., Lv, X. (2014) Characterization of Bbx, a member of a novel subfamily of the HMG-box superfamily together with Cic. Development genes and evolution. 224(4-6):261-8

Beck, B.B., Phillips, J.B., Bartram, M.P., Wegner, J., Thoenes, M., Pannes, A., Sampson, J., Heller, R., Göbel, H., Koerber, F., Neugebauer, A., Hedergott, A., Nürnberg, G., Nürnberg, P., Thiele, H., Altmüller, J., Toliat, M.R., Staubach, S., Boycott, K.M., Valente, E.M., Janecke, A.R., Eisenberger, T., Bergmann, C., Tebbe, L., Wang, Y., Wu, Y., Fry, A.M., Westerfield, M., Wolfrum, U., Bolz, H.J. (2014) Mutation of POC1B in a Severe Syndromic Retinal Ciliopathy. Human Mutation. 35(10):1153-62

Xiao, Q., Xia, J.H., Zhang, X.J., Li, Z., Wang, Y., Zhou, L., Gui, J.F. (2014) Type-IV Antifreeze Proteins are Essential for Epiboly and Convergence in Gastrulation of Zebrafish Embryos. International journal of biological sciences. 10:715-32

Zhang, Z., Jia, H., Zhang, Q., Wan, Y., Song, B., Jia, Q., Liu, H., Zhu, X., Fang, X. (2014) Transcriptome analysis of Rpl11-deficient zebrafish model of Diamond-Blackfan Anemia. Genomics Data. 2:173-5

Wang, Y., Sun, Z.H., Zhou, L., Li, Z., Gui, J.F. (2014) Grouper tshbeta Promoter-Driven Transgenic Zebrafish Marks Proximal Kidney Tubule Development. PLoS One. 9:e97806

Zhong, J.X., Zhou, L., Li, Z., Wang, Y., Gui, J.F. (2014) Zebrafish Noxa promotes mitosis in early embryonic development and regulates apoptosis in subsequent embryogenesis. Cell death and differentiation. 21:1013-24

Li, C., Ma, H., Wang, Y., Cao, Z., Graves-Deal, R., Powell, A.E., Starchenko, A., Ayers, G.D., Washington, M.K., Kamath, V., Desai, K., Gerdes, M.J., Solnica-Krezel, L., Coffey, R.J. (2014) Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J. Clin. Invest.. 124(5):2172-87

Shi, J., Zhang, Y.B., Zhang, J.S., and Gui, J.F. (2013) Expression regulation of zebrafish interferon regulatory factor 9 by promoter analysis. Developmental and comparative immunology. 41(4):534-543

Wang, Y., Zhou, L., Li, Z., Li, W., and Gui, J. (2013) Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish. Science China. Life sciences. 56(11):975-984

Yue, H.M., Li, Z., Wu, N., Liu, Z., Wang, Y., and Gui, J.F. (2013) Oocyte-Specific H2A Variant H2af1o Is Required for Cell Synchrony Before Mid-Blastula Transition in Early Zebrafish Embryos. Biology of reproduction. 89(4):82

Liu, Y., Zhang, Y.B., Liu, T.K., and Gui, J.F. (2013) Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family. PLoS One. 8(6):e66859

Zhang, Y.B., Liu, T.K., Jiang, J., Shi, J., Liu, Y., Li, S., and Gui, J.F. (2013) Identification of a novel gig2 gene family specific to non-amniote vertebrates. PLoS One. 8(4):e60588

Li, Z., Zheng, W., Wang, Z., Zeng, Z., Zhan, H., Li, C., Zhou, L., Yan, C., Spitsbergen, J.M., and Gong, Z. (2013) A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Disease models & mechanisms. 427(1):223-226

Xie, X., Tan, J., Wei, D., Lei, D., Yin, T., Huang, J., Zhang, X., Qiu, J., Tang, C., and Wang, G. (2013) In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish. Journal of the Royal Society, Interface. 10(82):20121053

Xu, S., Xia, W., Zohar, Y., and Gui, J.F. (2013) Zebrafish dmrta2 Regulates the Expression of cdkn2c in Spermatogenesis in the Adult Testis. Biology of reproduction. 88(1):14

Huang, X., Zhou, L., and Gong, Z. (2012) Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future oncology (London, England). 8(1):21-28

Li, S., Sun, F., Zhang, Y.B., Gui, J.F., and Zhang, Q.Y. (2012) Identification of DreI as an Antiviral Factor Regulated by RLR Signaling Pathway. PLoS One. 7(3):e32427

Wang, Y., Zhang, W., Wu, Z., Zhu, X., and Lu, C. (2011) Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence. Veterinary Microbiology. 152(1-2):151-60

Gou, M., Men, K., Shi, H., Xiang, M., Zhang, J., Song, J., Long, J., Wan, Y., Luo, F., Zhao, X., and Qian, Z. (2011) Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale. 3(4):1558-67

Wang, R., Li, Z., Wang, Y., and Gui, J.F. (2011) An apo-14 promoter-driven transgenic zebrafish that marks liver organogenesis. PLoS One. 6(7):e22555

Li, M., Hong, N., Xu, H., Yi, M., Li, C., Gui, J., Hong, Y. (2009) Medaka vasa is required for migration but not survival of primordial germ cells. Mechanisms of Development. 126(5-6):366–381

Yin, J., Xia, J.H., Du, X.Z., Liu, J., Zhou, L., Hong, Y.H., and Gui, J.F. (2007) Developmental expression of CagMdkb during gibel carp embryogenesis. The International journal of developmental biology. 51(8):761-769

Ji, G.D., Zhou, L., Wang, Y., Xia, W., and Gui, J.F. (2006) Identification of a novel C2 domain factor in ovaries of orange-spotted grouper (Epinephelus coioides). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 143(3):374-383

Wang, Y., Zhou, L., Yao, B., Li, C.J., and Gui, J.F. (2004) Differential expression of thyroid-stimulating hormone beta subunit in gonads during sex reversal of orange-spotted and red-spotted groupers. Molecular and Cellular Endocrinology. 220(1-2):77-88

Zhou, L., and Irwin, D.M. (2004) Fish proglucagon genes have differing coding potential. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 137(2):255-264