ZFIN ID: ZDB-LAB-110707-1
Zaghloul Lab
PI/Director: Zaghloul, Norann A.
Contact Person: Zaghloul, Norann A.
Email: zaghloul@umaryland.edu
URL: http://medschool.umaryland.edu/facultyresearchprofile/viewprofile.aspx?id=22658
Address: Department of Medicine University of Maryland School of Medicine 660 W. Redwood St, Howard Hall 425 Baltimore, MD 21201 USA
Country: United States
Phone: 410-706-2047
Fax: 410-706-1622
Line Designation: umd


GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Adeyemo, A.A., Zaghloul, N.A., Chen, G., Doumatey, A.P., Leitch, C.C., Hostelley, T.L., Nesmith, J.E., Zhou, J., Bentley, A.R., Shriner, D., Fasanmade, O., Okafor, G., Eghan, B., Agyenim-Boateng, K., Chandrasekharappa, S., Adeleye, J., Balogun, W., Owusu, S., Amoah, A., Acheampong, J., Johnson, T., Oli, J., Adebamowo, C., South Africa Zulu Type 2 Diabetes Case-Control Study, Collins, F., Dunston, G., Rotimi, C.N. (2019) ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response. Nature communications. 10:3195
Nesmith, J.E., Hostelley, T.L., Leitch, C.C., Matern, M.S., Sethna, S., McFarland, R., Lodh, S., Westlake, C.J., Hertzano, R., Ahmed, Z.M., Zaghloul, N.A. (2019) Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes. Human molecular genetics. 28:2212-2223
Edie, S., Zaghloul, N.A., Leitch, C.C., Klinedinst, D.K., Lebron, J., Thole, J.F., McCallion, A.S., Katsanis, N., Reeves, R.H. (2018) Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio.. G3 (Bethesda). 8(7):2215-2223
Montasser, M.E., O'Hare, E.A., Wang, X., Howard, A.D., McFarland, R., Perry, J.A., Ryan, K.A., Rice, K., Jaquish, C.E., Shuldiner, A.R., Miller, M., Mitchell, B.D., Zaghloul, N.A., Chang, Y.C. (2018) An APOO Pseudogene on Chromosome 5q is Associated with LDL-C Levels. Circulation. 138(13):1343-1355
Hostelley, T.L., Nesmith, J.E., Zaghloul, N.A. (2017) Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish. Journal of visualized experiments : JoVE. (128)
O'Hare, E.A., Yang, R., Yerges-Armstrong, L., Sreenivasan, U., McFarland, R., Leitch, C.C., Wilson, M.H., Narina, S., Gorden, A., Ryan, K., Shuldiner, A.R., Farber, S.A., Wood, G.C., Still, C.D., Gerhard, G.S., Robishaw, J.D., Sztalryd, C., Zaghloul, N.A. (2017) TM6SF2 rs58542926 impacts lipid processing in liver and small intestine. Hepatology (Baltimore, Md.). 65(5):1526-1542
Hostelley, T.L., Lodh, S., Zaghloul, N.A. (2016) Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes. BMC Genomics. 17:318
Khan, S.Y., Vasanth, S., Kabir, F., Gottsch, J.D., Khan, A.O., Chaerkady, R., Lee, M.W., Leitch, C.C., Ma, Z., Laux, J., Villasmil, R., Khan, S.N., Riazuddin, S., Akram, J., Cole, R.N., Talbot, C.C., Pourmand, N., Zaghloul, N.A., Hejtmancik, J.F., Riazuddin, S.A. (2016) FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Nature communications. 7:10953
O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
Lodh, S., Hostelley, T.L., Leitch, C.C., O'Hare, E.A., Zaghloul, N.A. (2016) Differential effects on β-cell mass by disruption of Bardet-Biedl Syndrome or Alstrom Syndrome genes. Human molecular genetics. 25(1):57-68
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
O'Hare, E.A., Wang, X., Montasser, M.E., Chang, Y.P., Mitchell, B.D., Zaghloul, N.A. (2014) Disruption of ldlr causes increased LDL-cholesterol and vascular lipid accumulation in a zebrafish model of hypercholesterolemia. Journal of Lipid Research. 55(11):2242-53
Leitch, C.C., Lodh, S., Prieto-Echagüe, V., Badano, J.L., Zaghloul, N.A. (2014) Basal body proteins regulate Notch signaling via endosomal trafficking. Journal of Cell Science. 127(Pt 11):2407-19
Liu, Y.P., Tsai, I.C., Morleo, M., Oh, E.C., Leitch, C.C., Massa, F., Lee, B.H., Parker, D.S., Finley, D., Zaghloul, N.A., Franco, B., Katsanis, N. (2014) Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J. Clin. Invest.. 124(5):2059-70
Kim, S., Zaghloul, N.A., Bubenshchikova, E., Oh, E.C., Rankin, S., Katsanis, N., Obara, T., and Tsiokas, L. (2011) Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nature cell biology. 13(4):351-60
Zaghloul, N.A., and Katsanis, N. (2011) Zebrafish assays of ciliopathies. Methods in cell biology. 105:257-272
Zaghloul, N.A., Liu, Y., Gerdes, J.M., Gascue, C., Oh, E.C., Leitch, C.C., Bromberg, Y., Binkley, J., Leibel, R.L., Sidow, A., Badano, J.L., and Katsanis, N. (2010) Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107(23):10602-10607
Riazuddin, S.A., Zaghloul, N.A., Al-Saif, A., Davey, L., Diplas, B.H., Meadows, D.N., Eghrari, A.O., Minear, M.A., Li, Y.J., Klintworth, G.K., Afshari, N., Gregory, S.G., Gottsch, J.D., and Katsanis, N. (2010) Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. American journal of human genetics. 86(1):45-53
Leitch, C.C., Zaghloul, N.A., Davis, E.E., Stoetzel, C., Diaz-Font, A., Rix, S., Al-Fadhel, M., Lewis, R.A., Eyaid, W., Banin, E., Dollfus, H., Beales, P.L., Badano, J.L., and Katsanis, N. (2008) Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome. Nature Genetics. 40(4):443-448
Li, C., Inglis, P.N., Leitch, C.C., Efimenko, E., Zaghloul, N.A., Mok, C.A., Davis, E.E., Bialas, N.J., Healey, M.P., Héon, E., Zhen, M., Swoboda, P., Katsanis, N., and Leroux, M.R. (2008) An Essential Role for DYF-11/MIP-T3 in Assembling Functional Intraflagellar Transport Complexes. PLoS Genetics. 4(3):e1000044
Gerdes, J.M., Liu, Y., Zaghloul, N.A., Leitch, C.C., Lawson, S.S., Kato, M., Beachy, P.A., Beales, P.L., Demartino, G.N., Fisher, S., Badano, J.L., and Katsanis, N. (2007) Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nature Genetics. 39(11):1350-1360
Stoetzel, C., Muller, J., Laurier, V., Davis, E.E., Zaghloul, N.A., Vicaire, S., Jacquelin, C., Plewniak, F., Leitch, C.C., Sarda, P., Hamel, C., de Ravel, T.J., Lewis, R.A., Friederich, E., Thibault, C., Danse, J.M., Verloes, A., Bonneau, D., Katsanis, N., Poch, O., Mandel, J.L., and Dollfus, H. (2007) Identification of a Novel BBS Gene (BBS12) Highlights the Major Role of a Vertebrate-Specific Branch of Chaperonin-Related Proteins in Bardet-Biedl Syndrome. American journal of human genetics. 80(1):1-11