ZFIN ID: ZDB-LAB-100716-1
Eberhart Lab
PI/Director: Eberhart, Johann
Contact Person: Swartz, Mary
Email: swartz@mail.utexas.edu
URL: http://www.sbs.utexas.edu/eberhart/index.html
Address: 1 University Station-Stop C1000 University of Texas at Austin Austin, TX 78713
Country: United States
Phone: 512-232-8271
Fax: 512-471-3878
Line Designation: au

Show all 8 genomic features

We study how genetics and the environment influence the cellular
mechanisms underlying craniofacial development. Craniofacial
morphogenesis requires the precise control of multiple cellular
processes, including cell movement, signaling, and differentiation.
Disruption of any one of the processes can result in craniofacial
disease, which is prevalent in humans. Our goal is to determine how
these varied cellular processes integrate during craniofacial
morphogenesis using the zebrafish as a model organism. Studies in the
lab utilize a variety of techniques including genetics, molecular
biology, and live imaging of embryos to finely dissect normal
craniofacial morphogenesis and help determine the causes of
craniofacial disease.

McCarthy, Neil Graduate Student Swartz, Mary Administrative Staff

Everson, J.L., Batchu, R., Eberhart, J.K. (2020) Multifactorial Genetic and Environmental Hedgehog Pathway Disruption Sensitizes Embryos to Alcohol-Induced Craniofacial Defects. Alcoholism, clinical and experimental research. 44(10):1988-1996
Aggarwal, K., Kuka, T.P., Banik, M., Medellin, B.P., Ngo, C.Q., Xie, D., Fernandes, Y., Dangerfield, T.L., Ye, E., Bouley, B., Johnson, K.A., Zhang, Y.J., Eberhart, J.K., Que, E.L. (2020) Visible light mediated bidirectional control over carbonic anhydrase activity in cells and in vivo using azobenzene sulfonamides. Journal of the American Chemical Society. 142(34):14522-14531
Swartz, M.E., Lovely, C.B., McCarthy, N., Kuka, T., Eberhart, J.K. (2019) Novel ethanol-sensitive mutants identified in an F3 forward genetic screen. Alcoholism, clinical and experimental research. 44(1):56-65
Buckley, D.M., Sidik, A., Kar, R.D., Eberhart, J.K. (2019) Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish. Birth defects research. 111(12):700-713
Fernandes, Y., Rampersad, M., Jones, E.M., Eberhart, J.K. (2018) Social deficits following embryonic ethanol exposure arise in post-larval zebrafish. Addiction biology. 24(5):898-907
Fernandes, Y., Rampersad, M., Eberhart, J.K. (2018) Social behavioral phenotyping of the zebrafish Casper mutant following embryonic alcohol exposure. Behavioural brain research. 356:46-50
Tang, X., Eberhart, J.K., Cleves, M.A., Li, J., Li, M., MacLeod, S., Nembhard, W.N., Hobbs, C.A. (2018) PDGFRA gene, maternal binge drinking and obstructive heart defects. Scientific Reports. 8:11083
McGurk, P.D., Swartz, M.E., Chen, J.W., Galloway, J.L., Eberhart, J.K. (2017) In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw. PLoS Genetics. 13:e1007112
Fernandes, Y., Buckley, D.M., Eberhart, J.K. (2017) Diving into the world of alcohol teratogenesis: A review of zebrafish models of fetal alcohol spectrum disorders. Biochemistry and cell biology = Biochimie et biologie cellulaire. 96(2):88-97
Lovely, C.B., Fernandes, Y., Eberhart, J.K. (2016) Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis. Zebrafish. 13(5):391-8
McCarthy, N., Sidik, A., Bertrand, J.Y., Eberhart, J.K. (2016) An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull. Developmental Biology. 415(2):261-77
Lovely, C.B., Swartz, M.E., McCarthy, N., Norrie, J.L., Eberhart, J.K. (2016) Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish. Development (Cambridge, England). 143(11):2000-11
McCarthy, N., Liu, J.S., Richarte, A.M., Eskiocak, B., Lovely, C.B., Tallquist, M.D., Eberhart, J.K. (2016) Pdgfra and Pdgfrb genetically interact during craniofacial development. Developmental dynamics : an official publication of the American Association of Anatomists. 245(6):641-52
Lovely, C.B., Nobles, R.D., Eberhart, J.K. (2014) Developmental age strengthens barriers to ethanol accumulation in zebrafish. Alcohol (Fayetteville, N.Y.). 48(6):595-602
Lovely, C.B., Eberhart, J.K. (2014) Commentary: catching a conserved mechanism of ethanol teratogenicity. Alcoholism, clinical and experimental research. 38:2160-3
Swartz, M.E., Wells, M.B., Griffin, M., McCarthy, N., Lovely, C.B., McGurk, P., Rozacky, J., and Eberhart, J.K. (2014) A Screen of Zebrafish Mutants Identifies Ethanol-Sensitive Genetic Loci. Alcoholism, clinical and experimental research. 38(3):694-703
McGurk, P.D., Lovely, C.B., and Eberhart, J.K. (2014) Analyzing craniofacial morphogenesis in zebrafish using 4D confocal microscopy. Journal of visualized experiments : JoVE. (83):e51190
Delaurier, A., Huycke, T.R., Nichols, J.T., Swartz, M.E., Larsen, A., Walker, C., Dowd, J., Pan, L., Moens, C.B., and Kimmel, C.B. (2014) Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Developmental Biology. 385(2):189-99
Sheehan-Rooney, K., Swartz, M.E., Zhao, F., Liu, D., and Eberhart, J.K. (2013) Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR). Disease models & mechanisms. 6(5):1285-91
McCarthy, N., Wetherill, L., Lovely, C.B., Swartz, M.E., Foroud, T.M., and Eberhart, J.K. (2013) Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development (Cambridge, England). 140(15):3254-3265
Sheehan-Rooney, K., Swartz, M.E., Lovely, C.B., Dixon, M.J., and Eberhart, J.K. (2013) Bmp and Shh Signaling Mediate the Expression of satb2 in the Pharyngeal Arches. PLoS One. 8(3):e59533
He, X., Yan, Y.L., Eberhart, J.K., Herpin, A., Wagner, T.U., Schartl, M., and Postlethwait, J.H. (2011) miR-196 regulates axial patterning and pectoral appendage initiation. Developmental Biology. 357(2):463-77
Swartz, M.E., Sheehan-Rooney, K., Dixon, M.J., and Eberhart, J.K. (2011) Examination of a palatogenic gene program in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 240(9):2204-2220
Eames, B.F., Yan, Y.L., Swartz, M.E., Levic, D.S., Knapik, E.W., Postlethwait, J.H., and Kimmel, C.B. (2011) Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation. PLoS Genetics. 7(8):e1002246
Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M. (2011) Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens. Developmental Biology. 350(1):50-63
Sheehan-Rooney, K., Pálinkášová, B., Eberhart, J.K., and Dixon, M.J. (2010) A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages. Developmental dynamics : an official publication of the American Association of Anatomists. 239(12):3481-3491
Delaurier, A., Eames, B.F., Blanco-Sánchez, B., Peng, G., He, X., Swartz, M.E., Ullmann, B., Westerfield, M., and Kimmel, C.B. (2010) Zebrafish sp7:EGFP: A transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis (New York, N.Y. : 2000). 48(8):505-511
He, X., Eberhart, J.K., and Postlethwait, J.H. (2009) MicroRNAs and micromanaging the skeleton in disease, development and evolution. Journal of Cellular and Molecular Medicine. 13(4):606-618
Kimmel, C.B., and Eberhart, J.K. (2008) The midline, oral ectoderm, and the arch-0 problem. Integrative and Comparative Biology. 48(5):668-680
Eberhart, J.K., He, X., Swartz, M.E., Yan, Y.L., Song, H., Boling, T.C., Kunerth, A.K., Walker, M.B., Kimmel, C.B., and Postlethwait, J.H. (2008) MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nature Genetics. 40(3):290-298
Miller, C.T., Swartz, M.E., Khuu, P.A., Walker, M.B., Eberhart, J.K., and Kimmel, C.B. (2007) mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish. Developmental Biology. 308(1):144-157
Walker, M.B., Miller, C.T., Swartz, M.E., Eberhart, J.K., and Kimmel, C.B. (2007) phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish. Developmental Biology. 304(1):194-207
Miller, M.R., Atwood, T.S., Eames, B.F., Eberhart, J.K., Yan, Y.L., Postlethwait, J.H., and Johnson, E.A. (2007) RAD marker microarrays enable rapid mapping of zebrafish mutations. Genome biology. 8(6):R105
Crump, J.G., Swartz, M.E., Eberhart, J.K., and Kimmel, C.B. (2006) Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development (Cambridge, England). 133(14):2661-9
Eberhart, J.K., Swartz, M.E., Crump, J.G., and Kimmel, C.B. (2006) Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development (Cambridge, England). 133(6):1069-1077
Crump, J.G., Swartz, M.E., and Kimmel, C.B. (2004) An Integrin-Dependent Role of Pouch Endoderm in Hyoid Cartilage Development. PLoS Biology. 2(9):E244
Swartz, M., Eberhart, J., Mastick, G.S., and Krull, C.E. (2001) Sparking new frontiers: using in vivo electroporation for genetic manipulations. Developmental Biology. 233(1):13-21