ZFIN ID: ZDB-LAB-100630-1
Ramchandran Lab
PI/Director: Ramchandran, Ramani
Contact Person: Leigh, Noah
Email: nleigh@mcw.edu
Address: C3420, 8401 Watertown Plank Road Milwaukee, 53226 USA
Country: United States
Phone: 414-955-2397
Fax: 414-955-6325
Line Designation: mw

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The Ramchandran Lab is interested in studying mechanisms related to vasculogenesis and angiogenesis during early embryonic development. We are also interested in developing zebrafish as a model system for target-based small molecule screening.

Li, Keguo Post-Doc Schupp, Marcus Post-Doc Sinha, Indranil Post-Doc
Chun, Chang Zoon Research Staff Horswill, Mark Research Staff Leigh, Noah Research Staff
Samant, Ganesh Research Staff

Gronseth, E., Gupta, A., Koceja, C., Kumar, S., Kutty, R.G., Rarick, K., Wang, L., Ramchandran, R. (2020) Astrocytes influence medulloblastoma phenotypes and CD133 surface expression. PLoS One. 15:e0235852
Dey, A., Prabhudesai, S., Zhang, Y., Rao, G., Thirugnanam, K., Hossen, M.N., Dwivedi, S.K.D., Ramchandran, R., Mukherjee, P., Bhattacharya, R. (2020) Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2. Science advances. 6(27):
Chowdhury, T.A., Li, K., Ramchandran, R. (2019) Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1. Vascular Pharmacology. 114:103-109
Eisa-Beygi, S., Benslimane, F.M., El-Rass, S., Prabhudesai, S., Abdelrasoul, M.K.A., Simpson, P.M., Yalcin, H.C., Burrows, P.E., Ramchandran, R. (2018) Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio). Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2806-2818
Prabhudesai, S., Koceja, C., Dey, A., Eisa-Beygi, S., Leigh, N.R., Bhattacharya, R., Mukherjee, P., Ramchandran, R. (2018) Corrigendum: Cystathionine β-Synthase Is Necessary for Axis Development in vivo.. Frontiers in cell and developmental biology. 6:121
Chowdhury, T.A., Koceja, C., Eisa-Beygi, S., Kleinstiver, B.P., Kumar, S.N., Lin, C.W., Li, K., Prabhudesai, S., Joung, J.K., Ramchandran, R. (2018) Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly.. Arteriosclerosis, Thrombosis, and Vascular Biology. 38(7):1562-1575
Prabhudesai, S., Koceja, C., Dey, A., Eisa-Beygi, S., Leigh, N.R., Bhattacharya, R., Mukherjee, P., Ramchandran, R. (2018) Cystathionine β-Synthase Is Necessary for Axis Development in Vivo.. Frontiers in cell and developmental biology. 6:14
Jia, M., Andreassen, T., Jensen, L., Bathen, T.F., Sinha, I., Gao, H., Zhao, C., Haldosén, L.A., Cao, Y., Girnita, L., Moestue, S.A., Dahlman-Wright, K. (2016) Estrogen receptor α promotes breast cancer by reprogramming choline metabolism. Cancer research. 76(19):5634-5646
Rana, U., Liu, Z., Kumar, S.N., Zhao, B., Hu, W., Bordas, M., Cossette, S., Szabo, S., Foeckler, J., Weiler, H., Chrzanowska-Wodnicka, M., Holtz, M.L., Misra, R.P., Salato, V., North, P., Ramchandran, R., Miao, Q.R. (2016) Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. Developmental Biology. 410(2):190-201
Chun, C., Wu, Y., Lee, S.H., Williamson, E.A., Reinert, B.L., Jaiswal, A.S., Nickoloff, J.A., Hromas, R.A. (2016) The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis. Cell cycle (Georgetown, Tex.). 15(7):957-62
Saha, S., Chakraborty, P.K., Xiong, X., Dwivedi, S.K., Mustafi, S.B., Leigh, N.R., Ramchandran, R., Mukherjee, P., Bhattacharya, R. (2016) Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(1):441-56
Hoeppner, L.H., Sinha, S., Wang, Y., Bhattacharya, R., Dutta, S., Gong, X., Bedell, V.M., Suresh, S., Chun, C.Z., Ramchandran, R., Ekker, S.C., Mukhopadhyay, D. (2015) RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. Journal of Cell Science. 128(19):3556-68
Schupp, M.O., Waas, M., Chun, C.Z., Ramchandran, R. (2014) Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. Developmental Biology. 393(1):71-83
Rajasimha, H.K., Shirol, P.B., Ramamoorthy, P., Hegde, M., Barde, S., Chandru, V., Ravinandan, M.E., Ramchandran, R., Haldar, K., Lin, J.C., Babar, I.A., Girisha, K.M., Srinivasan, S., Navaneetham, D., Battu, R., Devarakonda, R., Kini, U., Vijayachandra, K., Verma, I.C. (2014) Organization for rare diseases India (ORDI) - addressing the challenges and opportunities for the Indian rare diseases' community. Genetics research. 96:e009
Zhao, C., Qiao, Y., Jonsson, P., Wang, J., Xu, L., Rouhi, P., Sinha, I., Cao, Y., Williams, C., Dahlman-Wright, K. (2014) Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer. Cancer research. 74(14):3983-94
Zhou, X., Fan, L.X., Li, K., Ramchandran, R., Calvet, J.P., and Li, X. (2014) SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Human molecular genetics. 23(6):1644-55
Leigh, N.R., Schupp, M.O., Li, K., Padmanabhan, V., Gastonguay, A., Wang, L., Chun, C.Z., Wilkinson, G.A., and Ramchandran, R. (2013) Mmp17b is essential for proper neural crest cell migration in vivo. PLoS One. 8(10):e76494
Kilari, S., Remadevi, I., Zhao, B., Pan, J., Miao, R., Ramchandran, R., North, P.E., You, M., Rahimi, N., and Wilkinson, G.A. (2013) Endothelial Cell-Specific Chemotaxis Receptor (ECSCR) enhances Vascular Endothelial Growth Factor (VEGF) Receptor-2/Kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. The Journal of biological chemistry. 288(15):10265-10274
Patra, C.R., Kim, J.H., Pramanik, K., d'Uscio, L.V., Patra, S., Pal, K., Ramchandran, R., Strano, M.S., and Mukhopadhyay, D. (2011) Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods. Nano Letters. 11(11):4932-8
Samant, G.V., Schupp, M., Francois, M., Moleri, S., Kothinti, R.K., Chun, C.Z., Sinha, I., Sellars, S., Leigh, N., Pramanik, K., Horswill, M.A., Remadevi, I., Li, K., Wilkinson, G.A., Tabatabai, N.M., Beltrame, M., Koopman, P., and Ramchandran, R. (2011) Sox factors transcriptionally regulate ROBO4 expression in developing vasculature in Zebrafish. The Journal of biological chemistry. 286(35):30740-7
Lakshmikanthan, S., Sobczak, M., Chun, C., Henschel, A., Dargatz, J., Ramchandran, R., and Chrzanowska-Wodnicka, M. (2011) Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin alpha v beta 3. Blood. 118(7):2015-26
Chun, C.Z., Remadevi, I., Schupp, M.O., Samant, G.V., Pramanik, K., Wilkinson, G.A., and Ramchandran, R. (2011) Fli+ etsrp+ Hemato-Vascular Progenitor Cells Proliferate at the Lateral Plate Mesoderm during Vasculogenesis in Zebrafish. PLoS One. 6(2):e14732
Zhao, B., Chun, C., Liu, Z., Horswill, M.A., Pramanik, K., Wilkinson, G.A., Ramchandran, R., and Miao, R.Q. (2010) Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway. Blood. 116(24):5423-5433
Verma, A., Bhattacharya, R., Remadevi, I., Li, K., Pramanik, K., Samant, G.V., Horswill, M., Chun, C.Z., Zhao, B., Wang, E., Miao, R.Q., Mukhopadhyay, D., Ramchandran, R., and Wilkinson, G.A. (2010) Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. Blood. 115(22):4614-4622
Jia, Y., Wu, S.L., Isenberg, J.S., Dai, S., Sipes, J.M., Field, L., Zeng, B., Bandle, R.W., Ridnour, L.A., Wink, D.A., Ramchandran, R., Karger, B.L., and Roberts, D.D. (2010) Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell stress & chaperones. 15(2):165-181
Li, K., Blum, Y., Verma, A., Liu, Z., Pramanik, K., Leigh, N.R., Chun, C.Z., Samant, G.V., Zhao, B., Garnaas, M.K., Horswill, M.A., Stanhope, S.A., North, P.E., Miao, R.Q., Wilkinson, G.A., Affolter, M., and Ramchandran, R. (2010) A non-coding antisense RNA in tie-1 locus regulates tie-1 function in vivo. Blood. 115(1):133-139
Kanungo, J., Zheng, Y.L., Amin, N.D., Kaur, S., Ramchandran, R., and Pant, H.C. (2009) Specific Inhibition of Cyclin-dependent Kinase 5 Activity Induces Motor Neuron Development in vivo. Biochemical and Biophysical Research Communications. 386(1):263-267
Chun, C.Z., Kaur, S., Samant, G.V., Wang, L., Pramanik, K., Garnaas, M.K., Li, K., Field, L., Mukhopadhyay, D., and Ramchandran, R. (2009) Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. Blood. 113(5):1192-1199
Pramanik, K., Chun, C.Z., Garnaas, M.K., Samant, G.V., Li, K., Horswill, M.A., North, P.E., and Ramchandran, R. (2009) Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood. 113(5):1184-1191
Makky, K., Duvnjak, P., Pramanik, K., Ramchandran, R., and Mayer, A.N. (2008) A Whole-Animal Microplate Assay for Metabolic Rate Using Zebrafish. Journal of Biomolecular Screening. 13(10):960-967
Kaur, S., Samant, G.V., Pramanik, K., Loscombe, P.W., Pendrak, M.L., Roberts, D.D., and Ramchandran, R. (2008) Silencing Of Directional Migration In Roundabout4 Knockdown Endothelial Cells. BMC Cell Biology. 9:61
Garnaas, M.K., Moodie, K.L., Liu, M.L., Samant, G.V., Li, K., Marx, R., Baraban, J.M., Horowitz, A., and Ramchandran, R. (2008) Syx, a RhoA Guanine Exchange Factor, Is Essential for Angiogenesis In Vivo. Circulation research. 103(7):710-716
Kanungo, J., Li, B.S., Goswami, M., Zheng, Y.L., Ramchandran, R., and Pant, H.C. (2007) Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. Neuroscience letters. 412(3):233-238
Chun, C.Z., and Chen, T.T. (2007) Microinjecting recombinant rainbow trout Ea4-peptide of pro-IGF-I into zebrafish embryos causes abnormal development in heart, red blood cells, and vasculature. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 145(1):39-44
Kaur, S., Abu-Abab, M.S., Singla, S., Yeo, S.Y., and Ramchandran, R. (2007) Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development. Gene Expression. 13(6):321-327
Hu, G., Tang, J., Zhang, B., Lin, Y., Hanai, J.I., Galloway, J., Bedell, V., Bahary, N., Han, Z., Ramchandran, R., Thisse, B., Thisse, C., Zon, L.I., and Sukhatme, V.P. (2006) A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. Journal of Cell Science. 119(Pt 19):4117-4126
Chun, C.Z., Tsai, H.J., and Chen, T.T. (2006) Trout Ea4- or human Eb-peptide of pro-IGF-I disrupts heart, red blood cell, and vasculature development in zebrafish embryos. Molecular reproduction and development. 73(9):1112-1121
Kaur, S., Castellone, M.D., Bedell, V.M., Konar, M., Gutkind, J.S., and Ramchandran, R. (2006) Robo4 signaling in endothelial cells imply attraction guidance mechanisms. The Journal of biological chemistry. 281(16):11347-11356
Bedell, V.M., Yeo, S.Y., Park, K.W., Chung, J., Seth, P., Shivalingappa, V., Zhao, J., Obara, T., Sukhatme, V.P., Drummond, I.A., Li, D.Y., and Ramchandran, R. (2005) roundabout4 is essential for angiogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102(18):6373-6378
Chan, B., Sinha, S., Cho, D., Ramchandran, R., and Sukhatme, V.P. (2005) Critical roles of CD146 in zebrafish vascular development. Developmental dynamics : an official publication of the American Association of Anatomists. 232(1):232-244