ZFIN Lab: Renshaw Sheffield Lab

ZFIN ID: ZDB-LAB-080916-1

Renshaw Sheffield Lab

PI/Director:	Renshaw, Steve A.
Contact Person:	Renshaw, Steve A.
Email:	s.a.renshaw@sheffield.ac.uk
URL:	http://www.cdbg.group.shef.ac.uk/research/renshaw/
Address:	Bateson Centre D18, Firth Court Western Bank Sheffield S10 2TN
Country:	United Kingdom
Phone:	+44 114 2222336
Fax:	+44 114 2765413
Line Designation:	sh

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 26 genomic features

STATEMENT OF RESEARCH INTERESTS

Inflammation biology, neutrophil function, control of neutrophil lifespan, inflammation resolution, generation of immune system transgenics, forward genetic screens in the immune system, chemical genetic screens in the immune system, interleukin-1 processing and release

LAB MEMBERS

Elks, Phil Post-Doc	Henry, Katherine Post-Doc	Prajsnar, Thomasz Post-Doc
Robertson, Anne Post-Doc	Backer, Mumtaz Graduate Student	Burgon, Joseph Graduate Student
Lambein, Lore Graduate Student	Ogryzko, Nikolay Graduate Student	Robertson, James Graduate Student
Sadiku, Pranvira Graduate Student	Bojarczuk, Aleks Research Staff	Loynes, Catherine Research Staff
Williams, Alex Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Herman, K.D., Wright, C.G., Marriott, H.M., McCaughran, S.C., Bowden, K.A., Collins, M.O., Renshaw, S.A., Prince, L.R. (2022) The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages. Frontiers in immunology. 13:956991

Ellis, P.S., Martins, R.R., Thompson, E.J., Farhat, A., Renshaw, S.A., Henriques, C.M. (2022) A subset of gut leukocytes has telomerase-dependent "hyper-long" telomeres and require telomerase for function in zebrafish. Immunity & ageing : I & A. 19:31

Gibson, J.F., Bojarczuk, A., Evans, R.J., Kamuyango, A.A., Hotham, R., Lagendijk, A.K., Hogan, B.M., Ingham, P.W., Renshaw, S.A., Johnston, S.A. (2022) Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection. PLoS pathogens. 18:e1010389

Le Moigne, V., Rodriguez Rincon, D., Glatigny, S., Dupont, C.M., Langevin, C., Ait Ali Said, A., Renshaw, S.A., Floto, R.A., Herrmann, J.L., Bernut, A. (2022) Roscovitine Worsens Mycobacterium abscessus Infection by Reducing DUOX2-Mediated Neutrophil Response. American journal of respiratory cell and molecular biology. 66(4):439-451

Gibson, J.F., Pidwill, G.R., Carnell, O.T., Surewaard, B.G.J., Shamarina, D., Sutton, J.A.F., Jeffery, C., Derré-Bobillot, A., Archambaud, C., Siggins, M.K., Pollitt, E.J.G., Johnston, S.A., Serror, P., Sriskandan, S., Renshaw, S.A., Foster, S.J. (2021) Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species. PLoS pathogens. 17:e1009880

Isles, H.M., Loynes, C.A., Alasmari, S., Kon, F.C., Henry, K.M., Kadochnikova, A., Hales, J., Muir, C.F., Keightley, M.C., Kadirkamanathan, V., Hamilton, N., Lieschke, G.J., Renshaw, S.A., Elks, P.M. (2021) Pioneer neutrophils release chromatin within in vivo swarms. eLIFE. 10:

Sutton, J.A.F., Carnell, O.T., Lafage, L., Gray, J., Biboy, J., Gibson, J.F., Pollitt, E.J.G., Tazoll, S.C., Turnbull, W., Hajdamowicz, N.H., Salamaga, B., Pidwill, G.R., Condliffe, A.M., Renshaw, S.A., Vollmer, W., Foster, S.J. (2021) Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. PLoS pathogens. 17:e1009468

Buchan, K.D., van Gent, M., Prajsnar, T.K., Ogryzko, N.V., de Jong, N.W.M., Kolata, J., Foster, S.J., van Strijp, J.A.G., Renshaw, S.A. (2021) Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model. Journal of Cell Science. 134(5):

Foulkes, M.J., Tolliday, F.H., Henry, K.M., Renshaw, S.A., Jones, S. (2020) Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish. PLoS One. 15:e0240231

Hsu, J., Huang, H.T., Lee, C.T., Choudhuri, A., Wilson, N.K., Abraham, B.J., Moignard, V., Kucinski, I., Yu, S., Hyde, R.K., Tober, J., Cai, X., Li, Y., Guo, Y., Yang, S., Superdock, M., Trompouki, E., Calero-Nieto, F.J., Ghamari, A., Jiang, J., Gao, P., Gao, L., Nguyen, V., Robertson, A.L., Durand, E.M., Kathrein, K.L., Aifantis, I., Gerber, S.A., Tong, W., Tan, K., Cantor, A.B., Zhou, Y., Liu, P.P., Young, R.A., Göttgens, B., Speck, N.A., Zon, L.I. (2020) CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America. 117(38):23626-23635

Bernut, A., Loynes, C.A., Floto, R.A., Renshaw, S.A. (2020) Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Frontiers in immunology. 11:1733

Gibson, J.F., Prajsnar, T.K., Hill, C.J., Tooke, A.K., Serba, J.J., Tonge, R.D., Foster, S.J., Grierson, A.J., Ingham, P.W., Renshaw, S.A., Johnston, S.A. (2020) Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish. Autophagy. 17(6):1448-1457

Fenaroli, F., Robertson, J.D., Scarpa, E., Gouveia, V.M., Di Guglielmo, C., De Pace, C., Elks, P.M., Poma, A., Evangelopoulos, D., Ortiz Canseco, J., Marriott, H.M., Dockrell, D.H., Foster, S., McHugh, T.D., Renshaw, S.A., Samitier Marti, J., Battaglia, G., Rizzello, L. (2020) Polymersomes Eradicating Intracellular Bacteria. ACS nano. 14(7):8287-8298

Schild, Y., Mohamed, A., Wootton, E.J., Lewis, A., Elks, P.M. (2020) Hif-1alpha stabilisation is protective against infection in zebrafish comorbid models. The FEBS journal. 287(18):3925-3943

Hamilton, N., Rutherford, H.A., Petts, J.J., Isles, H.M., Weber, T., Henneke, M., Gärtner, J., Dunning, M.J., Renshaw, S.A. (2020) The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy. Glia. 68(7):1531-1545

Plant, T., Eamsamarng, S., Sanchez-Garcia, M.A., Reyes, L., Renshaw, S.A., Coelho, P., Mirchandani, A.S., Morgan, J.M., Ellett, F.E., Morrison, T., Humphries, D., Watts, E.R., Murphy, F., Raffo-Iraolagoitia, X.L., Zhang, A., Cash, J.L., Loynes, C., Elks, P.M., Van Eeden, F., Carlin, L.M., Furley, A.J.W., Whyte, M.K.B., Walmsley, S.R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. The Journal of Clinical Investigation. 130(6):3221-3237

Prajsnar, T.K., Serba, J.J., Dekker, B.M., Gibson, J.F., Masud, S., Fleming, A., Johnston, S.A., Renshaw, S.A., Meijer, A.H. (2020) The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 17(4):888-902

Stirling, D.R., Suleyman, O., Gil, E., Elks, P.M., Torraca, V., Noursadeghi, M., Tomlinson, G.S. (2020) Analysis tools to quantify dissemination of pathology in zebrafish larvae. Scientific Reports. 10:3149

Batalha, I.L., Bernut, A., Schiebler, M., Ouberai, M.M., Passemar, C., Klapholz, C., Kinna, S., Michel, S., Sader, K., Castro-Hartmann, P., Renshaw, S.A., Welland, M.E., Andres Floto, R. (2019) Polymeric nanobiotics as a novel treatment for mycobacterial infections. Journal of controlled release : official journal of the Controlled Release Society. 314:116-124

Rahman, A., Henry, K.M., Herman, K.D., Thompson, A.A.R., Isles, H.M., Tulotta, C., Sammut, D., Rougeot, J.J., Khoshaein, N., Reese, A.E., Higgins, K., Tabor, C., Sabroe, I., Zuercher, W.J., Savage, C.O., Meijer, A.H., Whyte, M.K., Dockrell, D.H., Renshaw, S.A., Prince, L.R. (2019) Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. eLIFE. 8

Lewis, A., Elks, P.M. (2019) Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo. Frontiers in immunology. 10:2321

Masud, S., van der Burg, L., Storm, L., Prajsnar, T.K., Meijer, A.H. (2019) Rubicon-Dependent Lc3 Recruitment to Salmonella-Containing Phagosomes Is a Host Defense Mechanism Triggered Independently From Major Bacterial Virulence Factors. Frontiers in cellular and infection microbiology. 9:279

Isles, H.M., Herman, K.D., Robertson, A.L., Loynes, C.A., Prince, L.R., Elks, P.M., Renshaw, S.A. (2019) The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish. Frontiers in immunology. 10:1784

Smith, R.E., Salamaga, B., Szkuta, P., Hajdamowicz, N., Prajsnar, T.K., Bulmer, G.S., Fontaine, T., Kołodziejczyk, J., Herry, J.M., Hounslow, A.M., Williamson, M.P., Serror, P., Mesnage, S. (2019) Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system. PLoS pathogens. 15:e1007730

Buchan, K.D., Prajsnar, T.K., Ogryzko, N.V., de Jong, N.W.M., van Gent, M., Kolata, J., Foster, S.J., van Strijp, J.A.G., Renshaw, S.A. (2019) A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase. PLoS One. 14:e0215592

Jones, C.N., Ellett, F., Robertson, A.L., Forrest, K.M., Judice, K., Balkovec, J.M., Springer, M., Markmann, J.F., Vyas, J.M., Warren, H.S., Irimia, D. (2019) Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro. Frontiers in immunology. 10:644

Evans, R.J., Pline, K., Loynes, C.A., Needs, S., Aldrovandi, M., Tiefenbach, J., Bielska, E., Rubino, R.E., Nicol, C.J., May, R.C., Krause, H.M., O'Donnell, V.B., Renshaw, S.A., Johnston, S.A. (2019) 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS pathogens. 15:e1007597

Hodgkinson, J.W., Belosevic, M., Elks, P.M., Barreda, D.R. (2019) Teleost contributions to the understanding of mycobacterial diseases. Developmental and comparative immunology. 96:111-125

Bernut, A., Dupont, C., Ogryzko, N.V., Neyret, A., Herrmann, J.L., Floto, R.A., Renshaw, S.A., Kremer, L. (2019) CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses. Cell Reports. 26:1828-1840.e4

Duvenage, L., Walker, L.A., Bojarczuk, A., Johnston, S.A., MacCallum, D.M., Munro, C.A., Gourlay, C.W. (2019) Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition. mBio. 10(1):

Masud, S., Prajsnar, T.K., Torraca, V., Lamers, G.E.M., Benning, M., Van Der Vaart, M., Meijer, A.H. (2019) Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model. Autophagy. 15(5):796-812

Ogryzko, N.V., Lewis, A., Wilson, H.L., Meijer, A.H., Renshaw, S.A., Elks, P.M. (2018) Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 202(2):494-502

Tsarouchas, T.M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N., Feng, Y., van Ham, T.J., Becker, T., Becker, C.G. (2018) Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration. Nature communications. 9:4670

Loynes, C.A., Lee, J.A., Robertson, A.L., Steel, M.J., Ellett, F., Feng, Y., Levy, B.D., Whyte, M.K.B., Renshaw, S.A. (2018) PGE₂ production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.. Science advances. 4:eaar8320

Hamilton, N., Sabroe, I., Renshaw, S.A. (2018) A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Research. 7:594

Ogryzko, N., Feng, Y. (2018) Helping hand for melanoma invasion: transparent zebrafish can catch macrophages in the act. Pigment cell & melanoma research. 31(4):459-460

van Leeuwen, L.M., Evans, R.J., Jim, K.K., Verboom, T., Fang, X., Bojarczuk, A., Malicki, J., Johnston, S.A., van der Sar, A.M. (2018) A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5.. Biology Open. 7(2)

McVicker, G., Prajsnar, T.K., Foster, S.J. (2018) Construction and Use of Staphylococcus aureus Strains to Study Within-Host Infection Dynamics. Methods in molecular biology (Clifton, N.J.). 1736:17-27

Prajsnar, T.K., McVicker, G., Williams, A., Renshaw, S.A., Foster, S.J. (2018) Use of Larval Zebrafish Model to Study Within-Host Infection Dynamics. Methods in molecular biology (Clifton, N.J.). 1736:147-156

Zhang, X., de Maat, V., Guzmán Prieto, A.M., Prajsnar, T.K., Bayjanov, J.R., de Been, M., Rogers, M.R.C., Bonten, M.J.M., Mesnage, S., Willems, R.J.L., van Schaik, W. (2017) RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum. BMC Genomics. 18:893

Connolly, J., Boldock, E., Prince, L.R., Renshaw, S.A., Whyte, M.K., Foster, S.J. (2017) The identification of Staphylococcus aureus factors required for pathogenicity and growth in human blood. Infection and Immunity. 85(11)

Prince, L.R., Dannewitz Prosseda, S., Higgins, K., Carlring, J., Prestwich, E.C., Ogryzko, N.V., Rahman, A., Basran, A., Falciani, F., Taylor, P., Renshaw, S.A., Whyte, M.K.B., Sabroe, I. (2017) NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood. 130(8):1014-1025

Gilbert, A.S., Seoane, P.I., Sephton-Clark, P., Bojarczuk, A., Hotham, R., Giurisato, E., Sarhan, A.R., Hillen, A., Velde, G.V., Gray, N.S., Alessi, D.R., Cunningham, D.L., Tournier, C., Johnston, S.A., May, R.C. (2017) Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5. Science advances. 3:e1700898

Salamaga, B., Prajsnar, T.K., Jareño-Martinez, A., Willemse, J., Bewley, M.A., Chau, F., Ben Belkacem, T., Meijer, A.H., Dockrell, D.H., Renshaw, S.A., Mesnage, S. (2017) Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis. PLoS pathogens. 13:e1006526

Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967

Robertson, J.D., Ward, J.R., Avila-Olias, M., Battaglia, G., Renshaw, S.A. (2017) Targeting Neutrophilic Inflammation Using Polymersome-Mediated Cellular Delivery. Journal of immunology (Baltimore, Md. : 1950). 198(9):3596-3604

Lopez, A., Lee, S.E., Wojta, K., Ramos, E.M., Klein, E., Chen, J., Boxer, A.L., Gorno-Tempini, M.L., Geschwind, D.H., Schlotawa, L., Ogryzko, N.V., Bigio, E.H., Rogalski, E., Weintraub, S., Mesulam, M.M., Fleming, A., Coppola, G., Miller, B.L., Rubinsztein, D.C. (2017) A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain : a journal of neurology. 140(4):1128-1146

Lee, J.A., Renshaw, S.A. (2017) Zebrafish screens for new colitis treatments - a bottom-up approach. The FEBS journal. 284:399-401

Robertson, A.L., Avagyan, S., Gansner, J.M., Zon, L.I. (2016) Understanding the regulation of vertebrate hematopoiesis and blood disorders: big lessons from a small fish. FEBS letters. 590(22):4016-4033

Widziolek, M., Prajsnar, T.K., Tazzyman, S., Stafford, G.P., Potempa, J., Murdoch, C. (2016) Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases. Scientific Reports. 6:36023

Robertson, A.L., Ogryzko, N.V., Henry, K.M., Loynes, C.A., Foulkes, M.J., Meloni, M.M., Wang, X., Ford, C., Jackson, M., Ingham, P.W., Wilson, H.L., Farrow, S.N., Solari, R., Flower, R.J., Jones, S., Whyte, M.K., Renshaw, S.A. (2016) Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. Disease models & mechanisms. 9(6):621-32

Bojarczuk, A., Miller, K.A., Hotham, R., Lewis, A., Ogryzko, N.V., Kamuyango, A.A., Frost, H., Gibson, R.H., Stillman, E., May, R.C., Renshaw, S.A., Johnston, S.A. (2016) Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection. Scientific Reports. 6:21489

Wiegertjes, G.F., Wentzel, A.S., Spaink, H.P., Elks, P.M., Fink, I.R. (2016) Polarization of immune responses in fish: The 'macrophages first' point of view. Molecular immunology. 69:146-56

Felber, K., Elks, P.M., Lecca, M., Roehl, H.H. (2015) Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation. PLoS One. 10:e0144982

Ellett, F., Elks, P.M., Robertson, A.L., Ogryzko, N.V., Renshaw, S.A. (2015) Defining the phenotype of neutrophils following reverse migration in zebrafish. Journal of Leukocyte Biology. 98(6):975-81

Keatinge, M., Bui, H., Menke, A., Chen, Y.C., Sokol, A.M., Bai, Q., Ellett, F., Da Costa, M., Burke, D., Gegg, M., Trollope, L., Payne, T., McTighe, A., Mortiboys, H., de Jager, S., Nuthhall, H., Kuo, M.S., Fleming, A., Schapira, A.H., Renshaw, S.A., Highley, J.R., Chacinska, A., Panula, P., Burton, E.A., O'Neill, M.J., Bandmann, O. (2015) Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Human molecular genetics. 24(23):6640-52

Messad, N., Prajsnar, T.K., Lina, G., O'Callaghan, D., Foster, S.J., Renshaw, S.A., Skaar, E.P., Bes, M., Dunyach-Remy, C., Vandenesch, F., Sotto, A., Lavigne, J.P. (2015) Existence of a Colonizing Staphylococcus aureus Strain Isolated in Diabetic Foot Ulcers. Diabetes. 64:2991-5

Schiebler, M., Brown, K., Hegyi, K., Newton, S.M., Renna, M., Hepburn, L., Klapholz, C., Coulter, S., Obregón-Henao, A., Henao Tamayo, M., Basaraba, R., Kampmann, B., Henry, K.M., Burgon, J., Renshaw, S.A., Fleming, A., Kay, R.R., Anderson, K.E., Hawkins, P.T., Ordway, D.J., Rubinsztein, D.C., Floto, R.A. (2015) Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. EMBO Molecular Medicine. 7(2):127-39

Hepburn, L., Prajsnar, T.K., Klapholz, C., Moreno, P., Loynes, C.A., Ogryzko, N.V., Brown, K., Schiebler, M., Hegyi, K., Antrobus, R., Hammond, K.L., Connolly, J., Ochoa, B., Bryant, C., Otto, M., Surewaard, B., Seneviratne, S.L., Grogono, D.M., Cachat, J., Ny, T., Kaser, A., Török, M.E., Peacock, S.J., Holden, M., Blundell, T., Wang, L., Ligoxygakis, P., Minichiello, L., Woods, C.G., Foster, S.J., Renshaw, S.A., Floto, R.A. (2014) Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Science (New York, N.Y.). 346:641-6

Ogryzko, N.V., Renshaw, S.A., Wilson, H.L. (2014) The IL-1 family in fish: Swimming through the muddy waters of inflammasome evolution. Developmental and comparative immunology. 46(1):53-62

Elks, P.M., van der Vaart, M., van Hensbergen, V., Schutz, E., Redd, M.J., Murayama, E., Spaink, H.P., Meijer, A.H. (2014) Mycobacteria Counteract a TLR-Mediated Nitrosative Defense Mechanism in a Zebrafish Infection Model. PLoS One. 9:e100928

Candel, S., de Oliveira, S., López-Muñoz, A., García-Moreno, D., Espín-Palazón, R., Tyrkalska, S.D., Cayuela, M.L., Renshaw, S.A., Corbalán-Vélez, R., Vidal-Abarca, I., Tsai, H.J., Meseguer, J., Sepulcre, M.P., Mulero, V. (2014) Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biology. 12:e1001855

McVicker, G., Prajsnar, T.K., Williams, A., Wagner, N.L., Boots, M., Renshaw, S.A., Foster, S.J. (2014) Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention. PLoS pathogens. 10:e1003959

Robertson, A.L., Holmes, G.R., Bojarczuk, A.N., Burgon, J., Loynes, C.A., Chimen, M., Sawtell, A.K., Hamza, B., Willson, J., Walmsley, S.R., Anderson, S.R., Coles, M.C., Farrow, S.N., Solari, R., Jones, S., Prince, L.R., Irimia, D., Rainger, G.E., Kadirkamanathan, V., Whyte, M.K., Renshaw, S.A. (2014) A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Science Translational Medicine. 6:225ra29

Burgon, J., Robertson, A.L., Sadiku, P., Wang, X., Hooper-Greenhill, E., Prince, L.R., Walker, P., Hoggett, E.E., Ward, J.R., Farrow, S.N., Zuercher, W.J., Jeffrey, P., Savage, C.O., Ingham, P.W., Hurlstone, A.F., Whyte, M.K., and Renshaw, S.A. (2014) Serum and Glucocorticoid-Regulated Kinase 1 Regulates Neutrophil Clearance during Inflammation Resolution. Journal of immunology (Baltimore, Md. : 1950). 192(4):1796-1805

Ogryzko, N.V., Hoggett, E.E., Solaymani-Kohal, S., Tazzyman, S., Chico, T.J., Renshaw, S.A., and Wilson, H.L. (2014) Zebrafish tissue injury causes up-regulation of interleukin-1 and caspase dependent amplification of the inflammatory response. Disease models & mechanisms. 7(2):259-64

Thompson, A.A., Elks, P.M., Marriott, H.M., Eamsamarng, S., Higgins, K.R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E.E., Formenti, F., Van Eeden, F.J., Kinnula, V.L., Pugh, C.W., Sabroe, I., Dockrell, D.H., Chilvers, E.R., Robbins, P.A., Percy, M.J., Simon, M.C., Johnson, R.S., Renshaw, S.A., Whyte, M.K., and Walmsley, S.R. (2014) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 123(3):366-76

Wang, X., Robertson, A.L., Li, J., Chai, R.J., Haishan, W., Sadiku, P., Ogryzko, N.V., Everett, M., Yoganathan, K., Luo, H.R., Renshaw, S.A., and Ingham, P.W. (2014) Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Disease models & mechanisms. 7(1):163-169

Prajsnar, T.K., Renshaw, S.A., Ogryzko, N.V., Foster, S.J., Serror, P., and Mesnage, S. (2013) Zebrafish as a novel vertebrate model to dissect enterococcal pathogenesis. Infection and Immunity. 81(11):4271-4279

Henry, K.M., Loynes, C.A., Whyte, M.K., and Renshaw, S.A. (2013) Zebrafish as a model for the study of neutrophil biology. Journal of Leukocyte Biology. 94(4):633-642

Henry, K.M., Pase, L., Ramos-Lopez, C.F., Lieschke, G.J., Renshaw, S.A., and Reyes-Aldasoro, C.C. (2013) PhagoSight: An Open-Source MATLAB® Package for the Analysis of Fluorescent Neutrophil and Macrophage Migration in a Zebrafish Model. PLoS One. 8(8):e72636

de Oliveira, S., Reyes-Aldasoro, C.C., Candel, S., Renshaw, S.A., Mulero, V., and Calado, A. (2013) Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response. Journal of immunology (Baltimore, Md. : 1950). 190(8):4349-59

Harris, J.M., Esain, V., Frechette, G.M., Harris, L.J., Cox, A.G., Cortes, M., Garnaas, M.K., Carroll, K.J., Cutting, C.C., Khan, T., Elks, P.M., Renshaw, S.A., Dickinson, B.C., Chang, C.J., Murphy, M.P., Paw, B.H., Vander Heiden, M.G., Goessling, W., and North, T.E. (2013) Glucose metabolism impacts the spatio-temporal onset and magnitude of HSC induction in vivo. Blood. 121(13):2483-2493

Elks, P.M., Brizee, S., van der Vaart, M., Walmsley, S.R., van Eeden, F.J., Renshaw, S.A., and Meijer, A.H. (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS pathogens. 9(12):e1003789

Holmes, G.R., Anderson, S.R., Dixon, G., Renshaw, S.A., and Kadirkamanathan, V. (2013) A Bayesian framework for identifying cell migration dynamics. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2013:3455-3458

Holmes, G.R., Anderson, S.R., Dixon, G., Robertson, A.L., Reyes-Aldasoro, C.C., Billings, S.A., Renshaw, S.A., and Kadirkamanathan, V. (2012) Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling. Journal of the Royal Society, Interface. 9(77):3229-3239

Pase, L., Layton, J.E., Wittmann, C., Ellett, F., Nowell, C.J., Reyes-Aldasoro, C.C., Varma, S., Rogers, K.L., Hall, C.J., Keightley, M.C., Crosier, P.S., Grabher, C., Heath, J.K., Renshaw, S.A., and Lieschke, G.J. (2012) Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish. Current biology : CB. 22(19):1818-1824

Prajsnar, T.K., Hamilton, R., Garcia-Lara, J., McVicker, G., Williams, A., Boots, M., Foster, S.J., and Renshaw, S.A. (2012) A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model. Cellular Microbiology. 14(10):1600-1619

Santhakumar, K., Judson, E.C., Elks, P.M., McKee, S., Elworthy, S., van Rooijen, E., Walmsley, S.S., Renshaw, S., Cross, S.S., and van Eeden, F.J. (2012) A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis. Cancer research. 72(16):4017-4027

Feng, Y., Renshaw, S., and Martin, P. (2012) Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE(2). Current biology : CB. 22(13):1253-1259

Dixon, G., Elks, P.M., Loynes, C.A., Whyte, M.K., and Renshaw, S.A. (2012) A Method for the In Vivo Measurement of Zebrafish Tissue Neutrophil Lifespan. ISRN Hematology. 2012:915868

Holmes, G.R., Dixon, G., Anderson, S.R., Reyes-Aldasoro, C.C., Elks, P.M., Billings, S.A., Whyte, M.K., Kadirkamanathan, V., and Renshaw, S.A. (2012) Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model. Advances in hematology. 2012:792163

Kadirkamanathan, V., Anderson, S.R., Billings, S.A., Zhang, X., Holmes, G.R., Reyes-Aldasoro, C.C., Elks, P.M., and Renshaw, S.A. (2012) The Neutrophil's Eye-View: Inference and Visualisation of the Chemoattractant Field Driving Cell Chemotaxis In Vivo. PLoS One. 7(4):e35182

Renshaw, S.A., and Trede, N.S. (2012) A model 450 million years in the making: zebrafish and vertebrate immunity. Disease models & mechanisms. 5(1):38-47

Bugeon, L., Taylor, H.B., Progatzky, F., Lin, M.I., Ellis, C.D., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S.A., Chico, T.J., Zon, L., Lamb, J., and Dallman, M.J. (2011) The NOTCH pathway contributes to cell fate decisions in myelopoiesis. Haematologica. 96(12):1753-60

Colucci-Guyon, E., Tinevez, J.Y., Renshaw, S.A., and Herbomel, P. (2011) Strategies of professional phagocytes in vivo: unlike macrophages, neutrophils engulf only surface-associated microbes. Journal of Cell Science. 124(Pt 18):3053-9

Elks, P.M., van Eeden, F.J., Dixon, G., Wang, X., Reyes-Aldasoro, C.C., Ingham, P.W., Whyte, M.K., Walmsley, S.R., and Renshaw, S.A. (2011) Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model. Blood. 118(3):712-22

Gray, C., Loynes, C.A., Whyte, M.K., Crossman, D.C., Renshaw, S.A., and Chico, T.J. (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish. Thrombosis and haemostasis. 105(5):811-819

Elks, P.M., Loynes, C.A., and Renshaw, S.A. (2011) Measuring Inflammatory Cell Migration in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 769:261-275

Renshaw, S.A., and Ingham, P.W. (2010) Zebrafish models of the immune response: taking it on the ChIn. BMC Biology. 8(1):148

Vergunst, A.C., Meijer, A.H., Renshaw, S.A., and O'Callaghan, D. (2010) Burkholderia cenocepacia creates an intra-macrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection. Infection and Immunity. 78(4):1495-1508

Loynes, C.A., Martin, J.S., Robertson, A., Trushell, D.M., Ingham, P.W., Whyte, M.K., and Renshaw, S.A. (2010) Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish. Journal of Leukocyte Biology. 87(2):203-212

Brugman, S., Liu, K.Y., Lindenbergh-Kortleve, D., Samsom, J.N., Furuta, G.T., Renshaw, S.A., Willemsen, R., and Nieuwenhuis, E.E. (2009) Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota. Gastroenterology. 137(5):1757.e1-1767.e1

Martin, J.S., and Renshaw, S.A. (2009) Using in vivo zebrafish models to understand the biochemical basis of neutrophilic respiratory disease. Biochemical Society transactions. 37(Pt 4):830-837

Li, N., Felber, K., Elks, P., Croucher, P., and Roehl, H.H. (2009) Tracking gene expression during zebrafish osteoblast differentiation. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(2):459-466

Prajsnar, T.K., Cunliffe, V.T., Foster, S.J., and Renshaw, S.A. (2008) A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens. Cellular Microbiology. 10(11):2312-2325

Roca, F.J., Mulero, I., López-Muñoz, A., Sepulcre, M.P., Renshaw, S.A., Meseguer, J., and Mulero, V. (2008) Evolution of the Inflammatory Response in Vertebrates: Fish TNF-{alpha} Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 181(7):5071-5081

Renshaw, S.A., Loynes, C.A., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2007) Modeling inflammation in the zebrafish: how a fish can help us understand lung disease. Experimental Lung Research. 33(10):549-554

Mathew, L.K., Sengupta, S., Kawakami, A., Andreasen, E.A., Löhr, C.V., Loynes, C.A., Renshaw, S.A., Peterson, R.T., and Tanguay, R.L. (2007) Unraveling tissue regeneration pathways using chemical genetics. The Journal of biological chemistry. 282(48):35202-35210

Renshaw, S.A., Loynes, C.A., Trushell, D.M., Elworthy, S., Ingham, P.W., and Whyte, M.K. (2006) A transgenic zebrafish model of neutrophilic inflammation. Blood. 108(13):3976-3978