ZFIN ID: ZDB-LAB-080331-1
William D. Richardson Lab
PI/Director: Richardson, William D.
Co-PI / Senior
Smith, Hazel K.
Contact Person: Richardson, William D.
Email: w.richardson@ucl.ac.uk
URL: http://www.ucl.ac.uk/~ucbzwdr/richardson.htm
Address: Wolfson Institute for Biomedical Research University College London Gower Street London WC1E 6BT
Country: United Kingdom
Phone: +44 (0)20 7679 6729
Fax: +44 (0)20 7209 0470
Line Designation: u

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We study development of the vertebrate central nervous system (CNS).
All of the many different kinds of neurons and glial cells in the CNS
develop from a set of indistinguishable neural precursor ('stem') cells
in the embryonic neural tube. Stem cells at different locations
generate different subsets of neurons and glial cells. For example,
stem cells in the so-called pMN domain of the ventral spinal cord
generate motor neurons and oligodendrocytes, while stem cells located
more dorsally generate interneurons and astrocytes. How do they do
this? Concentration gradients of key extracellular molecules such as
Sonic hedgehog (Shh) establish a spatial coordinate system which allows
stem cells to map their positions in the early neutral tube. Different
levels of Shh receptor occupancy somehow dictate different programs of
gene expression and cell differentiation. We are trying to 1) map the
stem cell origins of different classes of neurons and glia in the CNS
and 2) discover the extracellular signals and intracellular signals and
transcription factors that cause the stem cells to adopt their
particular fates. We use a wide range of techniques including
transgenesis in mice and zebrafish, chick embryology, cell culture and
time-lapse microscopy.

Li, Huiliang Post-Doc

Tawk, M., Makoukji, J., Belle, M., Fonte, C., Trousson, A., Hawkins, T., Li, H., Ghandour, S., Schumacher, M., and Massaad, C. (2011) Wnt/β-Catenin Signaling Is an Essential and Direct Driver of Myelin Gene Expression and Myelinogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(10):3729-3742
Li, H., Lu, Y., Smith, H.K., and Richardson, W.D. (2007) Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(52):14375-14382
Kazakova, N., Li, H., Mora, A., Jessen, K.R., Mirsky, R., Richardson, W.D., and Smith, H.K. (2006) A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes. Developmental Biology. 297(1):1-13