ZFIN ID: ZDB-LAB-080324-1
Marins Lab
PI/Director: Marins, Luis Fernando
Contact Person: Marins, Luis Fernando
Email: lfmarins@pq.cnpq.br
Address: Fundacao Universidade Federal do Rio Grande Departamento de Ciencias Fisiologicas Av. Italia Km 8 - CEP 96201-900 Rio Grande, RS Brazil
Country: Brazil
Phone: +55 (53) 3233-6851
Line Designation: ufb

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To develop transgenic fish for studying growth
sinalization and also models for pollution monitoring.

da Silveira, Cassaia Rodrigues Graduate Student Nornberg, Bruna Felix Graduate Student Rola, Regina Coimbra Graduate Student
Almeida, Daniela Volcan Research Staff da Rosa, Carlos Eduardo Research Staff Figueiredo, Marcio de Azevedo Research Staff
Kuradomi, Rafael Research Staff Lanes, Carlos Frederico Ceccon Research Staff Sandrini, Juliana Zomer Research Staff
Studzinski, Ana Lupe Motta Research Staff

Silveira, T., Kütter, M.T., Martins, C.M.G., Marins, L.F., Boyle, R.T., Campos, V.F., Remião, M.H. (2021) First Record of Clinostomum sp. (Digenea: Clinostomidae) in Danio rerio (Actinopterygii: Cyprinidae) and the Implication of Using Zebrafish from Pet Stores on Research. Zebrafish. 18(2):139-148
de Carvalho Penha, L.C., Rola, R.C., Dos Reis Martinez, C.B., de Martinez Gaspar Martins, C. (2020) Effects of anti-inflammatory diclofenac assessed by toxicity tests and biomarkers in adults and larvae of Danio rerio. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 242:108955
Rassier, G.T., Silveira, T.L.R., Remião, M.H., Daneluz, L.O., Martins, A.W.S., Dellagostin, E.N., Ortiz, H.G., Domingues, W.B., Komninou, E.R., Kütter, M.T., Marins, L.F.F., Campos, V.F. (2020) Evaluation of qPCR reference genes in GH-overexpressing transgenic zebrafish (Danio rerio). Scientific Reports. 10:12692
da Silva Barreto, J., de Melo Tarouco, F., da Rosa, C.E. (2020) Chlorothalonil causes redox state change leading to oxidative stress generation in Danio rerio. Aquatic toxicology (Amsterdam, Netherlands). 225:105527
Moraes, J.S., da Silva Nornberg, B.F., Castro, M.R., Vaz, B.D.S., Mizuschima, C.W., Marins, L.F.F., Martins, C.M.G. (2020) Zebrafish (Danio rerio) ability to activate ABCC transporters after exposure to glyphosate and its formulation Roundup Transorb®. Chemosphere. 248:125959
Costa, S.R., Velasques, R.R., Hoff, M.L.M., Souza, M.M., Sandrini, J.Z. (2019) Characterization of different DNA repair pathways in hepatic cells of Zebrafish (Danio rerio). DNA repair. 83:102695
Santos, K.O., Costa-Filho, J., Riet, J., Spagnol, K.L., Nornberg, B.F., Kütter, M.T., Tesser, M.B., Marins, L.F. (2019) Probiotic expressing heterologous phytase improves the immune system and attenuates inflammatory response in zebrafish fed with a diet rich in soybean meal. Fish & shellfish immunology. 93:652-658
Lopes, F.M., Sandrini, J.Z., Souza, M.M. (2018) Toxicity induced by glyphosate and glyphosate-based herbicides in the zebrafish hepatocyte cell line (ZF-L). Ecotoxicology and environmental safety. 162:201-207
Dalmolin, C., Almeida, D.V., Figueiredo, M.A., Marins, L.F. (2018) Expression profile of glucose transport-related genes under chronic and acute exposure to growth hormone in zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 221:1-6
Zago, D.C., Santos, A.C., Lanes, C.F.C., Almeida, D.V., Koakoski, G., de Abreu, M.S., Zeppenfeld, C.C., Heinzmann, B.M., Marins, L.F., Baldisserotto, B., Barcellos, L.J.G., Cunha, M.A. (2018) Aloysia triphylla in the zebrafish food: effects on physiology, behavior, and growth performance. Fish physiology and biochemistry. 44(2):465-474
Costa, S.R., Velasques, R.R., Rovani, M.T., Souza, M.M., Sandrini, J.Z. (2018) Comparison of the Base Excision Repair Activity in Liver Cell Models of Zebrafish (Danio rerio). Zebrafish. 15(2):107-111
Cruz, B.P., Brongar, L.F., Popiolek, P., Gonçalvez, B.S.B., Figueiredo, M.A., Amaral, I.P.G., Da Rosa, V.S., Nery, L.E.M., Marins, L.F. (2017) Clock genes expression and locomotor activity are altered along the light-dark cycle in transgenic zebrafish overexpressing growth hormone. Transgenic Research. 26(6):739-752
Lopes, F.M., Caldas, S.S., Primel, E.G., da Rosa, C.E. (2017) Glyphosate Adversely Affects Danio rerio Males: Acetylcholinesterase Modulation and Oxidative Stress. Zebrafish. 14(2):97-105
da Silva Peixoto, C., Parfitt, G.M., Bruch, G.E., Cordeiro, M.F., Almeida, D.V., Marins, L.F., Barros, D.M. (2017) Effects of learning on mTOR pathway gene expression in the brain of zebrafish (Danio rerio) of different ages. Experimental gerontology. 89:8-14
Silva, A.C., Almeida, D.V., Nornberg, B.F., Pereira, J.R., Pires, D.M., Corcini, C.D., Junior, A.S., Marins, L.F. (2017) Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR). Transgenic Research. 26(1):123-134
Bastos, C.L., Varela, A.S., Ferreira, S.P., Nornberg, B.F., Boyle, R.T. (2016) Who knows not where an anemone does wear his sting? Could polypeptides released from the columnar vesicles of Bunodosoma cangicum induce apoptosis in the ZF-L cell line?. Toxicon : official journal of the International Society on Toxinology. 124:73-82
Nornberg, B.F., Almeida, D.V., Figueiredo, M.A., Marins, L.F. (2016) GH indirectly enhances the regeneration of transgenic zebrafish fins through IGF2a and IGF2b. Transgenic Research. 25(5):743-9
Velasques, R.R., Zomer Sandrini, J., da Rosa, C.E. (2016) Roundup in Zebrafish: Effects on Oxidative Status and Gene Expression. Zebrafish. 13(5):432-41
da Costa, S.R., da Costa Monteiro, M., da Silva, F.M., Sandrini, J.Z. (2016) Methylene blue toxicity in zebrafish cell line is dependent on light exposure. Cell biology international. 40(8):895-905
Figueiredo, M., Boyle, R., Sandrini, J., Varela, A., Marins, L. (2016) High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish. Journal of molecular endocrinology. 56(1):47-54
Studzinski, A.L., Barros, D.M., Marins, L.F. (2015) Growth hormone (GH) increases cognition and expression of ionotropic glutamate receptors (AMPA and NMDA) in transgenic zebrafish (Danio rerio). Behavioural brain research. 294:36-42
Dalmolin, C., Almeida, D.V., Figueiredo, M.A., Marins, L.F. (2015) Food intake and appetite control in a GH-transgenic zebrafish. Fish physiology and biochemistry. 41(5):1131-41
Silva, A.C., Almeida, D.V., Figueiredo, M.A., Marins, L.F. (2015) Double Transgenic Zebrafish for Somatotrophic Axis: A Tool for Muscle Development and Growth Studies. Zebrafish. 12(3):268-9
Nornberg, B.F., Batista, C.R., Almeida, D.V., Trindade, G.S., Marins, L.F. (2015) ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells. Toxicology in vitro : an international journal published in association with BIBRA. 29(1):204-10
Rola, R.C., Marins, L.F., Nery, L.E., da Rosa, C.E., Sandrini, J.Z. (2014) Responses to ROS inducer agents in zebrafish cell line: differences between copper and UV-B radiation. Fish physiology and biochemistry. 40(6):1817-25
Lopes, F.M., Varela Junior, A.S., Corcini, C.D., da Silva, A.C., Guazzelli, V.G., Tavares, G., da Rosa, C.E. (2014) Effect of glyphosate on the sperm quality of zebrafish Danio rerio. Aquatic toxicology (Amsterdam, Netherlands). 155C:322-326
Almeida, D.V., Vaz, B., Azevedo Figueiredo, M., Junior, A.S., Marins, L.F. (2014) Fluorescent transgenic zebrafish as a biosensor for growth-related effects of methyl parathion. Aquatic toxicology (Amsterdam, Netherlands). 152C:147-151
Batista, C.R., Figueiredo, M.A., Almeida, D.V., Romano, L.A., and Marins, L.F. (2014) Impairment of the immune system in GH-overexpressing transgenic zebrafish (Danio rerio). Fish & shellfish immunology. 36(2):519-524
Almeida, D.V., Bianchini, A., and Marins, L.F. (2013) Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. General and comparative endocrinology. 194C:102-109
Figueiredo, M.A., Fernandes, R.V., Studzinski, A.L., Rosa, C.E., Corcini, C.D., Junior, A.S., and Marins, L.F. (2013) GH overexpression decreases spermatic parameters and reproductive success in two-years-old transgenic zebrafish males. Animal Reproduction Science. 139(1-4):162-7
Sandrini, J.Z., Rola, R.C., Lopes, F.M., Buffon, H.F., Freitas, M.M., Martins, C.D., and da Rosa, C.E. (2013) Effects of glyphosate on cholinesterase activity of the mussel Perna perna and the fish Danio rerio and Jenynsia multidentata: In vitro studies. Aquatic toxicology (Amsterdam, Netherlands). 130-131C:171-173
Almeida, D.V., de Martinez Gaspar Martins, C., de Azevedo Figueiredo, M., Lanes, C.F., Bianchini, A., and Marins, L.F. (2013) Growth hormone transgenesis affects osmoregulation and energy metabolism in zebrafish (Danio rerio). Transgenic Research. 22(1):75-88
Alves-Costa, F.A., Figueiredo, M.A., Lanes, C.F., Almeida, D.V., Marins, L.F., and Wasko, A.P. (2012) A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Anais da Academia Brasileira de Ciencias. 84(2):487-494
Figueiredo, M.A., Mareco, E.A., Silva, M.D., and Marins, L.F. (2012) Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish. Transgenic Research. 21(3):457-469
Kuradomi, R.Y., Figueiredo, M.A., Lanes, C.F., da Rosa, C.E., Almeida, D.V., Maggioni, R., Silva, M.D., and Marins, L.F. (2011) GH overexpression causes muscle hypertrophy independent from local IGF-I in a zebrafish transgenic model. Transgenic Research. 20(3):513-521
Amado, L.L., Rosa, C.E., Castro, M.R., Votto, A.P., Santos, L.C., Marins, L.F., Trindade, G.S., Fraga, D.S., Damé, R.C., Barros, D.M., Geracitano, L.A., Bianchini, A., de la Torre, F.R., and Monserrat, J.M. (2011) Integrated biological responses of zebrafish (Danio rerio) to analyze water quality in regions under anthropogenic influence. Chemosphere. 82(11):1563-1570
da Rosa, C.E., Figueiredo, M.A., Lanes, C.F., Almeida, D.V., and Marins, L.F. (2011) Genotype-dependent gene expression profile of the antioxidant defense system (ADS) in the liver of a GH-transgenic zebrafish model. Transgenic Research. 20(1):85-89
Almeida, D.V., da Silva Nornberg, B.F., Geracitano, L.A., Barros, D.M., Monserrat, J.M., and Marins, L.F. (2010) Induction of phase II enzymes and hsp70 genes by copper sulfate through the electrophile-responsive element (EpRE): insights obtained from a transgenic zebrafish model carrying an orthologous EpRE sequence of mammalian origin. Fish physiology and biochemistry. 36(3):347-353
Rosa, C.E., Kuradomi, R.Y., Almeida, D.V., Lannes, C.F., de Azevedo Figueiredo, M., Dytz, A.G., Fonseca, D.B., and Marins, L.F. (2010) GH overexpression modifies muscle expression of anti-oxidant enzymes and increases spinal curvature of old zebrafish. Experimental gerontology. 45(6):449-456
Sandrini, J.Z., Bianchini, A., Trindade, G.S., Nery, L.E., and Marins, L.F. (2009) Reactive oxygen species generation and expression of DNA repair-related genes after copper exposure in zebrafish (Danio rerio) ZFL cells. Aquatic toxicology (Amsterdam, Netherlands). 95(4):285-291
de Castro, M.R., Lima, J.V., Salomão, D., de Souza Valente, R., Dummer, N.S., de Aguiar, R.B., Dos Santos, L.C., Marins, L.F., Geracitano, L.A., Monserrat, J.M., and Barros, D.M. (2009) Behavioral and neurotoxic effects of arsenic exposure in zebrafish (Danio rerio, Teleostei: Cyprinidae). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 150(3):337-342
Ventura-Lima, J., de Castro, M.R., Acosta, D., Fattorini, D., Regoli, F., de Carvalho, L.M., Bohrer, D., Geracitano, L.A., Barros, D.M., Marins, L.F., da Silva, R.S., Bonan, C.D., Bogo, M.R., and Monserrat, J.M. (2009) Effects of arsenic (As) exposure on the antioxidant status of gills of the zebrafish Danio rerio (Cypridinae). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 149(4):538-543
Studzinski, A.L., Almeida, D.V., Lanes, C.F., Figueiredo, M.D., and Marins, L.F. (2009) SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). General and comparative endocrinology. 161(1):67-72
Sandrini, J.Z., Trindade, G.S., Nery, L.E., and Marins, L.F. (2009) Time-course Expression of DNA Repair-related Genes in Hepatocytes of Zebrafish (Danio rerio) After UV-B Exposure. Photochemistry and photobiology. 85(1):220-226
da Rosa, C.E., Figueiredo, M.A., Lanes, C.F., Almeida, D.V., Monserrat, J.M., and Marins, L.F. (2008) Metabolic rate and reactive oxygen species production in different genotypes of GH-transgenic zebrafish. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 149(1):209-214
Figueiredo, M.A., Lanes, C.F., Almeida, D.V., Proietti, M.C., and Marins, L.F. (2007) The effect of GH overexpression on GHR and IGF-I gene regulation in different genotypes of GH-transgenic zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 2(3):228-233
Figueiredo, M.A., Lanes, C.F.C., Almeida, D.V., and Marins, L.F. (2007) Improving the production of transgenic fish germlines: in vivo evaluation of mosaicism in zebrafish (Danio rerio) using a green fluorescent protein (GFP) and growth hormone cDNA transgene co-injection strategy. Genetics and Molecular Biology. 30(1):31-36