ZFIN Lab: Lab D38

ZFIN ID: ZDB-LAB-050202-1

Lab D38

PI/Director:	Chico, Tim J.
Contact Person:	Chico, Tim J.
Email:	t.j.chico@sheffield.ac.uk
URL:
Address:	Bateson Centre Firth Court University of Sheffield Sheffield, S10 2TF United Kingdom
Country:	United Kingdom
Phone:	00 44 114 222 2395
Fax:	00 44 114 261 9587
Line Designation:	sh

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 6 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Gray, Caroline Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Snodgrass, R.O., Govindpani, K., Plant, K., Kugler, E.C., Doh, C., Dawson, T., McCormack, L.E., Arthur, H.M., Chico, T.J.A. (2023) Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia. Disease models & mechanisms. 16(4):

Canham, L., Sendac, S., Diagbouga, M.R., Wolodimeroff, E., Pirri, D., Tardajos Ayllon, B., Feng, S., Souilhol, C., Chico, T.J.A., Evans, P.C., Serbanovic-Canic, J. (2023) EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(4):547-561

Kugler, E.C., Rampun, A., Chico, T.J.A., Armitage, P.A. (2022) Analytical Approaches for the Segmentation of the Zebrafish Brain Vasculature. Current protocols. 2:e443

Kugler, E.C., Frost, J., Silva, V., Plant, K., Chhabria, K., Chico, T.J.A., Armitage, P.A. (2022) Zebrafish Vascular Quantification (ZVQ): a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis. Development (Cambridge, England). 149(3):

Kugler, E., Snodgrass, R., Bowley, G., Plant, K., Serbanovic-Canic, J., Hamilton, N., Evans, P.C., Chico, T., Armitage, P. (2021) The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. Vascular biology (Bristol, England). 3:1-16

Derrick, C.J., Sánchez-Posada, J., Hussein, F., Tessadori, F., Pollitt, E.J.G., Savage, A.M., Wilkinson, R.N., Chico, T.J., van Eeden, F.J., Bakkers, J., Noël, E.S. (2021) Asymmetric Hapln1a drives regionalised cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular research. 118(1):226-240

Chhabria, K., Vouros, A., Gray, C., MacDonald, R.B., Jiang, Z., Wilkinson, R.N., Plant, K., Vasilaki, E., Howarth, C., Chico, T.J.A. (2019) Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Disease models & mechanisms. 12(9):

Kugler, E.C., van Lessen, M., Daetwyler, S., Chhabria, K., Savage, A.M., Silva, V., Plant, K., MacDonald, R.B., Huisken, J., Wilkinson, R.N., Schulte-Merker, S., Armitage, P., Chico, T.J. (2019) Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish. EMBO reports. 20:e47047

Elworthy, S., Savage, A.M., Wilkinson, R.N., Malicki, J.J., Chico, T.J.A. (2019) The role of endothelial cilia in post-embryonic vascular development. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(6):410-425

Savage, A.M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R.B., Kim, H.R., Wilson, H.L., van Eeden, F.J.M., Armesilla, A.L., Chico, T.J.A., Wilkinson, R.N. (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature communications. 10:732

Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S. (2019) Venous identity requires BMP signalling through ALK3. Nature communications. 10:453

Kugler, E., Plant, K., Chico, T., Armitage, P. (2019) Enhancement and Segmentation Workflow for the Developing Zebrafish Vasculature. Journal of imaging. 5(1):

Chhabria, K., Plant, K., Bandmann, O., Wilkinson, R.N., Martin, C., Kugler, E., Armitage, P.A., Santoscoy, P.L., Cunliffe, V.T., Huisken, J., McGown, A., Ramesh, T., Chico, T.J., Howarth, C. (2018) The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 40(2):298-313

Brown, H.K., Schiavone, K., Tazzyman, S., Heymann, D., Chico, T.J. (2017) Zebrafish xenograft models of cancer and metastasis for drug discovery. Expert opinion on drug discovery. 12(4):379-389

Serbanovic-Canic, J., de Luca, A., Warboys, C., Ferreira, P.F., Luong, L.A., Hsiao, S., Gauci, I., Mahmoud, M., Feng, S., Souilhol, C., Bowden, N., Ashton, J.P., Walczak, H., Firmin, D., Krams, R., Mason, J.C., Haskard, D.O., Sherwin, S., Ridger, V., Chico, T.J., Evans, P.C. (2017) Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(1):130-143

Dee, C.T., Nagaraju, R.T., Athanasiadis, E.I., Gray, C., Fernandez Del Ama, L., Johnston, S.A., Secombes, C.J., Cvejic, A., Hurlstone, A.F. (2016) CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 197(9):3520-3530

Mahmoud, M., Kim, H.R., Xing, R., Hsiao, S., Mammmoto, A., Chen, J., Serbanovic-Canic, J., Feng, S., Bowden, N.P., Maguire, R., Ariaans, M., Francis, S., Weinberg, P.D., Van der Heiden, K., Jones, E.A., Chico, T.J., Ridger, V.C., Evans, P.C. (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation research. 119(3):450-62

Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611

Gray, C. (2015) New insights into blood vessel remodelling during development and disease using the zebrafish.. Ph.D. Thesis.

Ogryzko, N.V., Hoggett, E.E., Solaymani-Kohal, S., Tazzyman, S., Chico, T.J., Renshaw, S.A., and Wilson, H.L. (2014) Zebrafish tissue injury causes up-regulation of interleukin-1 and caspase dependent amplification of the inflammatory response. Disease models & mechanisms. 7(2):259-64

Gorsi, B., Liu, F., Ma, X., Chico, T.J., Shrinivasan, A., Kramer, K.L., Bridges, E., Monteiro, R., Harris, A.L., Patient, R., and Stringer, S.E. (2014) The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity. Angiogenesis. 17(1):77-91

Watson, O., Novodvorsky, P., Gray, C., Rothman, A.M., Lawrie, A., Gerhardt, H., Crossman, D.C., Haase, A., McMahon, K., Gering, M., van Eeden, F.J., and Chico, T.J. (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling. Cardiovascular research. 100(2):252-61

Gray, C., Bratt, D., Lees, J., Dacosta, M., Plant, K., Solaymani-Kohal, S., Tazzyman, S., Serbanovic-Canic, J., Crossman, D.C., Keavney, B.D., Haase, A., McMahon, K., Gering, M., Roehl, H., Evans, P.C., and Chico, T.J. (2013) Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development. Arterioscler. Thromb. Vasc. Biol.. 33(6):1257-63

Novodvorsky, P., da Costa, M.M.J., and Chico, T.J.A. (2013) Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today: Technologies. 10(1):e109-e114

Quaife, N.M., Watson, O., and Chico, T.J. (2012) Zebrafish: an emerging model of vascular development and remodelling. Current opinion in pharmacology. 12(5):608-614

Bugeon, L., Taylor, H.B., Progatzky, F., Lin, M.I., Ellis, C.D., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S.A., Chico, T.J., Zon, L., Lamb, J., and Dallman, M.J. (2011) The NOTCH pathway contributes to cell fate decisions in myelopoiesis. Haematologica. 96(12):1753-60

Bratt, D.G., Lees, J., Crossman, D.C., Gering, M., and Chico, T.J. (2011) 18 Parathyroid hormone receptor 1 knockdown induces localised aortic occlusion by down regulating notch signalling in zebrafish. Heart (British Cardiac Society). 97(20):e7

Holden, B.J., van Eeden, F.J., Ong, A.C., and Chico, T.J. (2011) 32 PKD2 mutant zebrafish display excessive developmental angiogenesis. Heart (British Cardiac Society). 97(20):e7

Lara, R., Mauri, F.A., Taylor, H., Derua, R., Shia, A., Gray, C., Nicols, A., Shiner, R.J., Schofield, E., Bates, P.A., Waelkens, E., Dallman, M., Lamb, J., Zicha, D., Downward, J., Seckl, M.J., and Pardo, O.E. (2011) An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis. Oncogene. 30(32):3513-21

Holden, B.J., Bratt, D.G., and Chico, T.J. (2011) Molecular control of vascular development in the zebrafish. Birth defects research. Part C, Embryo today : reviews. 93(2):134-140

Gray, C., Loynes, C.A., Whyte, M.K., Crossman, D.C., Renshaw, S.A., and Chico, T.J. (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish. Thrombosis and haemostasis. 105(5):811-819

Chico, T.J., Milo, M., and Crossman, D.C. (2010) The genetics of cardiovascular disease: new insights from emerging approaches. The Journal of pathology. 220(2):186-197

Packham, I.M., Gray, C., Heath, P.R., Hellewell, P.G., Ingham, P.W., Crossman, D.C., Milo, M., and Chico, T.J. (2009) Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos. Physiological Genomics. 38(3):319-327

Rocke, J., Lees, J., Packham, I., and Chico, T. (2009) The zebrafish as a novel tool for cardiovascular drug discovery. Recent advances in cardiovascular drug discovery. 4(1):1-5

Chico, T.J., Ingham, P.W., and Crossman, D.C. (2008) Modeling cardiovascular disease in the zebrafish. Trends in cardiovascular medicine. 18(4):150-155

Gray, C., Packham, I.M., Wurmser, F., Eastley, N.C., Hellewell, P.G., Ingham, P.W., Crossman, D.C., and Chico, T.J. (2007) Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos. Arterioscler. Thromb. Vasc. Biol.. 27(10):2135-2141