ZFIN ID: ZDB-LAB-040810-5
Kramer Lab
PI/Director: Kramer, Kenneth
Contact Person: Kramer, Kenneth
Email: KenKramer@creighton.edu
URL: http://medschool.creighton.edu/faculty-directory-profile/100733
Address: Creighton University School of Medicine 2500 California Plaza Criss I Rm 325 Omaha, NE 68178
Country: United States
Phone: 301-451-0257
Line Designation: cru

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The vertebrate inner ear relies on specialized bundles of cilia on the apical surface of sensory hair cells to transduce sound and movement into electrical signals. The Kramer Lab uses the transparency of the early zebrafish embryo to visualize how ciliary linkages to extracellular structures regulate inner ear function. Using modern genetic and imaging tools, we collaborate with several labs across campus to determine how zebrafish mutants and drug treatments affect hearing and balance behaviors.

Goodman, Linda Research Staff

Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
Thiessen, K.D., Grzegorski, S.J., Chin, Y., Higuchi, L., Wilkinson, C.J., Shavit, J.A., Kramer, K.L. (2019) Zebrafish otolith biomineralization requires polyketide synthase. Mechanisms of Development. 157:1-9
Barta, C.L., Liu, H., Chen, L., Giffen, K.P., Li, Y., Kramer, K.L., Beisel, K.W., He, D.Z. (2018) RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells. Scientific data. 5:180005
Lundberg, Y.W., Xu, Y., Thiessen, K.D., Kramer, K.L. (2015) Mechanisms of otoconia and otolith development. Developmental dynamics : an official publication of the American Association of Anatomists. 244(3):239-53
Venero Galanternik, M., Kramer, K.L., Piotrowski, T. (2015) Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration. Cell Reports. 10(30):414-428
Gorsi, B., Liu, F., Ma, X., Chico, T.J., Shrinivasan, A., Kramer, K.L., Bridges, E., Monteiro, R., Harris, A.L., Patient, R., and Stringer, S.E. (2014) The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity. Angiogenesis. 17(1):77-91
Gee, S.T., Milgram, S.L., Kramer, K.L., Conlon, F.L., Moody, S.A. (2011) Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone.. PLoS One. 6(6):e20309
Zhang, Z., Alpert, D., Francis, R., Chatterjee, B., Yu, Q., Tansey, T., Sabol, S.L., Cui, C., Bai, Y., Koriabine, M., Yoshinaga, Y., Cheng, J.F., Chen, F., Martin, J., Schackwitz, W., Gunn, T.M., Kramer, K.L., De Jong, P.J., Pennacchio, L.A., and Lo, C.W. (2009) Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy. Proceedings of the National Academy of Sciences of the United States of America. 106(9):3219-3224
Kramer, K.L. and Yost, H.J. (2003) Heparan sulfate core proteins in cell-cell signaling. Annual review of genetics. 37:461-484
Kramer, K.L. and Yost, H.J. (2002) Cardiac left-right development: are the early steps conserved?. Cold Spring Harbor symposia on quantitative biology. 67:37-43