ZFIN ID: ZDB-LAB-040708-1
Rob Wilkinson
PI/Director: Wilkinson, Robert
Contact Person: Wilkinson, Robert
Email: Rob.Wilkinson@nottingham.ac.uk
URL:
Address: School of Life Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham NG7 2UH
Country: United Kingdom
Phone: 44 1158232429
Fax:
Line Designation: sh


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 13 genomic features


STATEMENT OF RESEARCH INTERESTS
We study genetic control of blood vessel formation and function with a focus on regulation of angiogenesis and vascular integrity by cell signalling. We also study how cell signalling is disrupted during cardiovascular diseases and how this contributes to endothelial dysfunction. We are interested in how endothelial cells (ECs) are organised into vascular networks, how cellular rearrangements are controlled during angiogenesis, how ECs interpret positional information and what the signals involved are.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Derrick, C.J., Sánchez-Posada, J., Hussein, F., Tessadori, F., Pollitt, E.J.G., Savage, A.M., Wilkinson, R.N., Chico, T.J., van Eeden, F.J., Bakkers, J., Noël, E.S. (2021) Asymmetric Hapln1a drives regionalised cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular research. 118(1):226-240
Farrugia, C., Stafford, G.P., Potempa, J., Wilkinson, R.N., Chen, Y., Murdoch, C., Widziolek, M. (2020) Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis. The FEBS journal. 288(5):1479-1495
Chhabria, K., Vouros, A., Gray, C., MacDonald, R.B., Jiang, Z., Wilkinson, R.N., Plant, K., Vasilaki, E., Howarth, C., Chico, T.J.A. (2019) Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Disease models & mechanisms. 12(9):
Kugler, E.C., van Lessen, M., Daetwyler, S., Chhabria, K., Savage, A.M., Silva, V., Plant, K., MacDonald, R.B., Huisken, J., Wilkinson, R.N., Schulte-Merker, S., Armitage, P., Chico, T.J. (2019) Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish. EMBO reports. 20:e47047
Arhatte, M., Gunaratne, G.S., El Boustany, C., Kuo, I.Y., Moro, C., Duprat, F., Plaisant, M., Duval, H., Li, D., Picard, N., Couvreux, A., Duranton, C., Rubera, I., Pagnotta, S., Lacas-Gervais, S., Ehrlich, B.E., Marchant, J.S., Savage, A.M., van Eeden, F.J.M., Wilkinson, R.N., Demolombe, S., Honoré, E., Patel, A. (2019) TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nature communications. 10:2024
Elworthy, S., Savage, A.M., Wilkinson, R.N., Malicki, J.J., Chico, T.J.A. (2019) The role of endothelial cilia in post-embryonic vascular development. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(6):410-425
Savage, A.M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R.B., Kim, H.R., Wilson, H.L., van Eeden, F.J.M., Armesilla, A.L., Chico, T.J.A., Wilkinson, R.N. (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature communications. 10:732
Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S. (2019) Venous identity requires BMP signalling through ALK3. Nature communications. 10:453
Chhabria, K., Plant, K., Bandmann, O., Wilkinson, R.N., Martin, C., Kugler, E., Armitage, P.A., Santoscoy, P.L., Cunliffe, V.T., Huisken, J., McGown, A., Ramesh, T., Chico, T.J., Howarth, C. (2018) The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 40(2):298-313
Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
Gutiérrez, H.C., O'Leary, A., Freudenberg, F., Fedele, G., Wilkinson, R., Markham, E., van Eeden, F., Reif, A., Norton, W.H.J. (2017) Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 30:30-43
Kurusamy, S., López-Maderuelo, D., Little, R., Cadagan, D., Savage, A.M., Ihugba, J.C., Baggott, R.R., Rowther, F.B., Martínez-Martínez, S., Arco, P.G., Murcott, C., Wang, W., Francisco Nistal, J., Oceandy, D., Neyses, L., Wilkinson, R.N., Cartwright, E.J., Redondo, J.M., Armesilla, A.L. (2017) Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion. Journal of Molecular and Cellular Cardiology. 109:38-47
Baxendale, S., van Eeden, F., Wilkinson, R. (2017) The Power of Zebrafish in Personalised Medicine. Advances in experimental medicine and biology. 1007:179-197
Thambyrajah, R., Ucanok, D., Jalali, M., Hough, Y., Wilkinson, R.N., McMahon, K., Moore, C., Gering, M. (2016) A gene trap transposon eliminates haematopoietic expression of zebrafish Gfi1aa, but does not interfere with haematopoiesis. Developmental Biology. 417(1):25-39
Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611
Wilkinson, R.N., Jopling, C., van Eeden, F.J. (2014) Zebrafish as a model of cardiac disease. Progress in molecular biology and translational science. 124:65-91
Wilkinson, R.N., van Eeden, F.J. (2014) The zebrafish as a model of vascular development and disease. Progress in molecular biology and translational science. 124:93-122
Wilkinson, R.N., Elworthy, S., Ingham, P.W., and van Eeden, F.J. (2013) A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies. Biotechniques. 55(6):314-316
Wilkinson, R.N., Koudijs, M.J., Patient, R.K., Ingham, P.W., Schulte-Merker, S., and van Eeden, F.J. (2012) Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood. 120(2):477-488
Wilkinson, R.N., Pouget, C., Gering, M., Russell, A.J., Davies, S.G., Kimelman, D., and Patient, R. (2009) Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta. Developmental Cell. 16(6):909-916
Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., Ten Dijke, P., and Mummery, C. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental Biology. 315(1):55-71
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