Community Action Needed: Please respond to the NIH RFI
ZFIN ID: ZDB-LAB-001018-1
P. Paul Liu Lab
PI/Director: Liu, Pu Paul
Contact Person: Diemer, Jamie
Email: jamie.diemer@nih.gov
URL: http://www.genome.gov/Staff/Liu/
Address: National Human Genome Research Group The National Institutes of Health 49 Convent Drive Building 49, Room 3A18 Bethesda, MD 20892 USA
Country: United States
Phone: (301) 402-2341
Fax: (301) 402-4929
Line Designation: hg


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 7 genomic features


STATEMENT OF RESEARCH INTERESTS
Our reseach focuses on zebrafish models of hematopoetic diseases and malignancies.


LAB MEMBERS
Bresciani, Erica Post-Doc Diemer, Jamie Administrative Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Mazzola, M., Pezzotta, A., Fazio, G., Rigamonti, A., Bresciani, E., Gaudenzi, G., Pelleri, M.C., Saitta, C., Ferrari, L., Parma, M., Fumagalli, M., Biondi, A., Cazzaniga, G., Marozzi, A., Pistocchi, A. (2020) Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects. Journal of Cellular and Molecular Medicine. 24(11):6272-6282
Mazzola, M., Deflorian, G., Pezzotta, A., Ferrari, L., Fazio, G., Bresciani, E., Saitta, C., Ferrari, L., Fumagalli, M., Parma, M., Marasca, F., Bodega, B., Riva, P., Cotelli, F., Biondi, A., Marozzi, A., Cazzaniga, G., Pistocchi, A. (2019) NIPBL: a new player in myeloid cells differentiation. Haematologica. 104(7):1332-1341
Bresciani, E., Broadbridge, E., Liu, P.P. (2018) An efficient dissociation protocol for generation of single cell suspension from zebrafish embryos and larvae. MethodsX. 5:1287-1290
Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813
Colombo, E.A., Carra, S., Fontana, L., Bresciani, E., Cotelli, F., Larizza, L. (2015) A zebrafish model of Poikiloderma with Neutropenia recapitulates the human syndrome hallmarks and traces back neutropenia to the myeloid progenitor. Scientific Reports. 5:15814
Connelly, J.P., Kwon, E.M., Gao, Y., Trivedi, N.S., Elkahloun, A.G., Horwitz, M.S., Cheng, L., Liu, P.P. (2014) Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects. Blood. 124(12):1926-30
Hao, H., Veleri, S., Sun, B., Kim, D.S., Keeley, P.W., Kim, J.W., Yang, H.J., Yadav, S.P., Manjunath, S.H., Sood, R., Liu, P., Reese, B.E., Swaroop, A. (2014) Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Human molecular genetics. 23(16):4260-71
Bresciani, E., Carrington, B., Wincovitch, S., Jones, M., Gore, A.V., Weinstein, B.M., Sood, R., Liu, P.P. (2014) CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish. Blood. 124(1):70-8
Cermenati, S., Moleri, S., Neyt, C., Bresciani, E., Carra, S., Grassini, D.R., Omini, A., Goi, M., Cotelli, F., Fran├žois, M., Hogan, B.M., and Beltrame, M. (2013) Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1238-47
Cunningham, L., Finckbeiner, S., Hyde, R.K., Southall, N., Marugan, J., Yedavalli, V.R., Dehdashti, S.J., Reinhold, W.C., Alemu, L., Zhao, L., Yeh, J.R., Sood, R., Pommier, Y., Austin, C.P., Jeang, K.T., Zheng, W., and Liu, P. (2012) Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction. Proceedings of the National Academy of Sciences of the United States of America. 109(36):14592-14597
Jin, H., Li, L., Xu, J., Zhen, F., Zhu, L., Liu, P.P., Zhang, M., Zhang, W., and Wen, Z. (2012) Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood. 119(22):5239-5249
Sood, R., and Liu, P. (2012) Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models. Advances in hematology. 2012:830703
Finckbeiner, S., Ko, P.J., Carrington, B., Sood, R., Gross, K., Dolnick, B., Sufrin, J., and Liu, P. (2011) Transient Knockdown and Overexpression Reveal a Developmental Role for the Zebrafish enosf1b Gene. Cell & Bioscience. 1:32
Sood, R., English, M.A., Belele, C.L., Jin, H., Bishop, K., Haskins, R., McKinney, M.C., Chahal, J., Weinstein, B.M., Wen, Z., and Liu, P.P. (2010) Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood. 115(14):2806-2809
Belele, C.L., English, M.A., Chahal, J., Burnetti, A., Finckbeiner, S.M., Gibney, G., Kirby, M., Sood, R., and Liu, P. (2009) Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish. Blood. 114(25):5162-5172
Jin, H., Sood, R., Xu, J., Zhen, F., English, M.A., Liu, P.P., and Wen, Z. (2009) Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development (Cambridge, England). 136(4):647-654
Sood, R., English, M.A., Jones, M., Mullikin, J., Wang, D.M., Anderson, M., Wu, D., Chandrasekharappa, S.C., Yu, J., Zhang, J., and Liu, P.P. (2006) Methods for reverse genetic screening in zebrafish by resequencing and TILLING. Methods (San Diego, Calif.). 39(3):220-227
Nishikawa, K., Kobayashi, M., Masumi, A., Lyons, S.E., Weinstein, B.M.,Liu, P.P., and Yamamoto, M. (2003) Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Molecular and cellular biology. 23(22):8295-8305
Lyons, S.E., Lawson, N.D., Lei, L., Bennett, P.E., Weinstein, B.M., and Liu, P.P. (2002) A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proceedings of the National Academy of Sciences of the United States of America. 99(8):5454-5459
Lyons, S.E., Shue, B.C., Lei, L., Oates, A.C., Zon, L.I., and Liu, P.P. (2001) Molecular cloning, genetic mapping, and expression analysis of four zebrafish c/ebp genes. Gene. 281(1-2):43-51
Lyons, S.E., Shue, B.C., Oates, A.C., Zon, L.I., and Liu, P.P. (2001) A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain. Blood. 97(9):2611-2617
Blake, T., Adya, N., Kim, C.H., Oates, A.C., Zon, L., Chitnis, A., Weinstein, B.M., and Liu, P.P. (2000) Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 96(13):4178-4184
Lyons, S.E., Lawson, N.D., Bennett, P.J., Weinstein, B.M., and Liu, P.P. (2000) Nonsense mutation in gata1 identified in the "bloodless" zebrafish vlad tepes. Blood. 96(11):2400
Lyons, S.E., Shue, B.C., Oates, A.C., Zon, L.I., and Liu, P.P. (2000) A novel myeloid-restricted zebrafish C/EBP with a potent transcriptional activation domain. Blood. 96(11):2877