IMAGE

Fig 6

ID

ZDB-IMAGE-260710-16

Genes

col8a1a

Publication

Williams-Ward et al., 2026 - Yap1 regulates motility and vertebral development and prevents kyphoscoliosis in zebrafish

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Figures for Williams-Ward et al., 2026

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Figure Caption

Fig 6 Altered hypochord marker distribution in yap1^kg151 mutant.
In situ mRNA hybridisation for collagen genes implicated in kyphoscoliosis and fast myosin heavy chain genes involved in axial patterning in sibling embryos reared from a yap1^kg151/+ in-cross at non-permissive temperature (28.5ºC) that were photographed and subsequently PCR genotyped. (A,B) Collagen extracellular matrix genes col9a1b (A) and col8a1a (B) are unchanged in 36 hpf notochord (arrows) of mutants compared to their siblings. Col8a1a mRNA is abundant in sibling hypochord throughout the axis (B, arrowheads, shown magnified in insets), but lacking in several segments in mutants (B, brackets). Additional col8a1a-stained embryos of each genotype are shown in S11 Fig. (C,D) In contrast, the axially-patterned localisation of fast myosin heavy chains fmyhc1.2 (D, trunk) and fmyhc2.1 (E; tail) is unaltered at 48 hpf. Numbers of (individuals with the pattern shown)/ (total genotyped individuals) are displayed on each panel. Bars = 100 μm.

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Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.