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Hoffmann et al., 2026 - Linking shox/shox2 deficiency with fgfr3 gain-of-function and natriuretic peptides

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Figure 3

Tissue-specific nCounter expression analysis of fgfr3 in zebrafish embryos 55 hpf upon shox(A), shox2(B) and shox/shox2(C) knockdown in fin (n=3), heart (n=4-5), head (n=4) and whole embryo (n=6). MO = morpholino. (D) Body length of zebrafish embryos 72 hpf after shox and shox2 knockdown and CNP treatment (10 µM), assessed in 10–15 whole embryos per condition (n=3). (E) nCounter expression analysis of fgfr3, nppa, nppb, nppc in zebrafish embryos 72 hpf after shox and shox2 knockdown and CNP treatment (10µM), assessed in 10–15 whole embryos per condition (n=2). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. MO = morpholino, hpf = hours post fertilization, n = number of independent experiments.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)