Figure 3

Figure 3

SERPINA family members, proteases, and apolipoproteins are dysregulated in pFSGS. Abundance of SERPINA family members (A), proteases (B), and apolipoproteins (C) in sera of patients with pFSGS, healthy CTRL, and other proteinuric diseases including sFSGS (other disease). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are given as normalized value. Shown is median±SEM. (D) Serum SERPINA1 concentration of patients with pFSGS, sFSGS, other proteinuric diseases without FSGS and healthy CTRL. *P < 0.05, **P < 0.001. Shown is median±SEM. (E) Urinary SERPINA1 concentration normalized to urine creatinine of patients with pFSGS, sFSGS, other proteinuric diseases without FSGS and CTRL. ****P < 0.0001. Shown is median±SEM. CTSZ, cathepsin Z; FETUB, Fetuin B; MMP3, matrix metalloproteinase 3; sFSGS, secondary FSGS.