ZFIN Image: Pistocchi et al., 2026, FIGURE 1

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Figure Caption

FIGURE 1

ints11 deficient embryos displayed developmental delay and altered motor response. (A–C) Representative images of 4 dpf controls (ctrl) injected with (A) either standard morpholino (std‐MO) or Cas9/tracrRNA and larvae injected with (B) ints11‐sMO and (C) ints11‐sgRNA. Scale bar indicates 300 μm. (D) Touch‐evoked escape response assay performed at 2.5 dpf in controls (n = 40), ints11‐sMO (n = 38) and ints11‐sgRNA (n = 42) embryos. Proportion of embryos with normal TR: Ctrl 39/40; ints11‐sMO: 13/38; ints11‐sgRNA: 12/42. Proportion of embryos with altered TR: Ctrl 1/40; ints11‐sMO: 25/38; ints11‐sgRNA: 30/42. In the histograms the percentage of embryos is expressed as mean ± SEM. Chi‐squared test with Holm–Bonferroni. Refer to Table S3 for raw statistical data. ***p < 0.001. ns not significant.

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurochem.