Fig. 6 Overrepresentation analysis (ORA) and optokinetic response (OKR) reveal alterations in ube3a visual function. a ORA using DisGeNET for ube3a upregulated genes (Ube3aUp). b ORA using Glad4U for Ube3aUp. c ORA using autism-related databases for Ube3aUp. d Scheme illustrating custom-made OKR equipment; created with BioRender. e Representative eye positions of the WT and mutant. f OKR parameters measured (saccade frequency, left; tracking gain, middle; ocular range, right); N = 15; multiple unpaired t tests and correction via the Holm‒Sidak method. The data are presented as the mean ± SEM. *P < 0.05.
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