IMAGE

Fig. 4

ID

ZDB-IMAGE-251231-4

Genes

hbbe1.1
rag1

Publication

Shi et al., 2025 - Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hematopoiesis

All Figures

Figures for Shi et al., 2025

Image

Figure Caption

Fig. 4

Minoxidil and wnt4 loss suppress hematopoiesis and partially reverse MDS-like myeloid expansion. A SB staining of 4 dpf c-myb^hyper embryos treated with increasing concentrations of minoxidil (0, 0.04, 0.4, and 4 mM). B Quantification of SB-positive neutrophils in the CHT region under the indicated conditions (mean ± SD; Student’s t-test; ns, not significant; ***P < 0.001; ****P < 0.0001). C, D WISH of rag1 expression at 4 dpf in WT and c-myb^hyper larvae treated with two concentrations of minoxidil (0.4 mM and 4 mM). Red arrowheads indicate rag1⁺ lymphocytes. Larvae were categorized into high, medium, or low expression groups based on staining intensity. (Chi-square test; replicates = 3, n > 3; ns, not significant; *P < 0.05; ****P < 0.0001). E–F WISH of βe1-globin expression at 4 dpf in WT and c-myb^hyper larvae treated with two concentrations of minoxidil (0.4 mM and 4 mM). Red arrowheads indicate βe1⁺ erythrocytes. Embryos were classified into high, medium, or low expression groups based on staining intensity. (Chi-square test, replicates = 3, n > 3; ns, not significant; ****P < 0.0001)

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Commun. Signal.