ZFIN Image: Farr et al., 2025, Fig 6

Image

Figure Caption

Fig 6 pomp and psmd6 mutants exhibit myocardial cell blebbing.

A.-C. Ventral views of hearts as maximum intensity projections (MIPs) of the entire myocardium, labeled with myl7:EGFP in 4 dpf larvae. Scale bar = 100 μm. V, ventricle. A, atrium. D.-F. Ventral views of hearts as MIPs of 2-7 slices (1.6-5.6 μm total section thickness) through the ventral ventricular wall, labeled with myl7:EGFP in 4 dpf larvae. Arrows in E and F indicate examples of rounded cardiomyocytes in the interior wall of the ventricle. Hearts in D - F are from different larvae than those in A - C. Presence of rounded trabecular cardiomyocytes: 0/17 pomp⁺^/⁺, 1/15 psmd6⁺^/⁺, 25/29 pomp^-/-, 24/27 psmd6^-/-. All embryos were genotyped. Scale bar = 50 μm. G. Graph showing numbers of protruding rounded cardiomyocytes per heart at 4 dpf. Only cells clearly projecting outward from the surface of the heart were counted. Each dot represents a heart/larva. Bars represent mean +/- SD. N = 9-13 per genotype. **** P < 0.0001.

Figure Data

Phenotype details

Acknowledgments

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