ZFIN Image: Varela et al., 2025, Figure 2

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Figure Caption

Figure 2

Differential gene expression analysis between cdkl5^−/− mutant zebrafish and WT siblings at 5 dpf (A,C,E) and 35 dpf (B,D,F). (A,B) Heatmap of hierarchical clustering analysis of differentially expressed genes (DEGs), based on log2(FPKM+1) values. Each column corresponds to a different sample, while each row represents a distinct gene. Red and green colors indicate genes with higher and lower expression levels, respectively. (C,D) The number of differentially expressed genes in cdkl5^−/− vs. WT groups. (E,F) Volcano plots show the distribution of the differentially expressed genes. The abscissa axis represents the value of log2FoldChange, and the ordinate axis represents the statistical significance value (−log10 (p value)) of gene expression between the groups. Red and green dots indicate significantly upregulated (up) and downregulated (down) genes, respectively. Blue dots represent genes with no statistically significant differences in expression (no) between the two groups.

Acknowledgments

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