ZFIN Image: Lin et al., 2025, Fig. 6

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Figure Caption

Fig. 6 Extensive transcriptional regulation of circadian clock genes by Amh/Bmpr2a-Smad1/5/9 signalling.A Column chart showing the percentages of circadian clock genes bound by P-Smad1/5/9 revealed by the CUT&Tag assay in pituitaries from WT, amh−/− and bmpr2a−/− mutants. B UCSC Genome Browser tracks of CUT&Tag signals at circadian clock genes, such as the rev-erbβ2 loci. C Metagene analysis showing the CUT&Tag signals of P-Smad1/5/9 at circadian clock gene promoters in WT, amh−/− and bmpr2a−/− pituitaries. Two-sided unpaired t-test, ***p = 1.568e-08 (WT vs amh−/−), ***p = 5.546e-05 (WT vs bmpr2a−/−). TSS, transcription start site. D The numbers of typical clock gene cis-regulatory elements bound by P-Smad1/5/9. E Global profile of P-Smad1/5/9 at typical cis-regulatory elements of clock genes.

Acknowledgments

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