ZFIN Image: Zheng et al., 2025, Figure 6

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Figure 6

Enrichment analysis of differentially expressed genes in cdh23^−/− reveals expression of Ca²⁺ pathway and cell apoptosis-related pathways. (A) GO enrichment analysis reveals differential expressions. Abscissa represents Gene Ratio, which is ratio of actual enriched genes in gene set for each GO term to total number of genes. Ordinate represents various enriched GO terms. p value measures significance of enrichment, with smaller values indicating greater statistical significance. (B) Differential expression genes with KEGG enrichment. Volcano plot shows enrichment of various KEGG terms and genes enriched in each pathway. Count value represents number of genes with different enrichment results. -log10 (p value) value measures the significance of enrichment, with a higher value indicating greater statistical significance. (C,D) Increased TUNEL staining in cdh23^−/− retinas. TUNEL staining (green) on cryosections of 3 dpf zebrafish retinas revealed apoptotic cells. Zebrafish larvae were embedded for transverse sectioning. Scale bar = 400 μm.

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Acknowledgments

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