ZFIN Image: Burrows et al., 2024, Fig. 4

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Figure Caption

Fig. 4 Adult C9orf72-ALS/FTD zebrafish show reduced swimming endurance. Kaplan–Meier analysis of swim tunnel performance in 6-month 12-month-old zebrafish. (A) The 2mer (Ctrl) zebrafish show no significant decline in swimming endurance between 6- and 12-month time points. Both (B) sense (S5) and (C) antisense (AS1) zebrafish lines significantly decline in swimming endurance between 6 and 12 months old. N = 9 2mer (Ctrl), N = 10 sense (S5) and N = 10 antisense (AS1). Log-rank (Mantel-Cox) test; *p < 0.05, **p < 0.01, ***p < 0.001. ALS = amyotrophic lateral sclerosis; FTD = frontotemporal dementia. [Color figure can be viewed at www.annalsofneurology.org]

Acknowledgments

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