Fig. 3 Embryonic and adult C9orf72-ALS/FTD zebrafish lines produce multiple RAN-translated DPR species. V5-DPRs and poly-repeats species GP, GR, and PR in (A) sense (S5) and (B) antisense (AS1) 5 days postfertilization embryonic lysates compared to non-transgenic (NTG) and 2mer (Ctrl). V5-DPR species detected in 12 month (C) brain and (D) muscle lysates of sense (S5) and antisense (AS1) C9orf72-ALS/FTD zebrafish. Arrows indicate DPR bands which are proposed to be driven by RAN-translation. Asterisks indicate non-specific antibody binding. ALS = amyotrophic lateral sclerosis; FTD = frontotemporal dementia; DPR = dipeptide repeat; RAN = repeat-associated non-AUG.
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