ZFIN Image: Ranjan et al., 2024, Figure 7

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Figure Caption

Figure 7 Epigenetic regulation of prozb through scar-6 locus is important for vascular function and hemostatic process.

Hypothetical schematic of scar-6 locus in wild-type zebrafish, where scar-6 elncRNA and prdm14-PRC2 complex hypermethylated the proximal CpG island and inhibits CTCF binding. In scar-6^{gib007Δ12/Δ12} mutant zebrafish. The 12 bp deletion affects the binding of the scar-6 elncRNA and prdm14-PRC2 complex leading to a partial change in methylation. This change allows the CTCF occupancy at the locus further mediating sub-TAD looping of the enhancer-promoter of prozb. This causes upregulation of prozb leading to endothelial cell activation via the PAR2-NF-κB pathway and causing vascular dysfunction leading to hemorrhage.

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