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Fig. 7 Overview of effects of HSP60 dysfunction (A) Schematic summary of consequences of HSP60 deficiency: (a) mitochondrial matrix protein levels are decreased, (b) leading to changes in cellular metabolism, (c) altering the pool of acetyl-CoA that alters the lipid metabolism (d), and finally activating ISRmt. Created with Biorender.com . (B) Simplified overview summarizing the changes in gene expression of metabolic enzymes and respiratory chain complexes at RNA and protein level affecting metabolic pathways and the respiratory chain as observed in HEK D423A cells induced for 72 h compared to uninduced cells.