ZFIN Image: Lu et al., 2024, Fig. 6

Image

Figure Caption

Fig. 6 Impact of a dopamine antagonist on dopaminergic and serotonergic neuron specification in zebrafish brain at 72 hours after fertilization. A and B: Tyrosine hydroxylase (TH) immunostaining in the control group (A) and in the dopamine antagonist–treated group (B). C: Quantification of TH-positive neurons in the diencephalic dopaminergic cluster (DDC). Significant differences in the normalized area of TH-positive neurons in the DDC were observed between the control and SCH 23390–treated groups (df = 12) using an unpaired t-test. D and E: 5-hydroxytryptamine (5-HT) immunostaining in the control group (D) and in the dopamine antagonist–treated group (E). F: Normalized quantification of 5-HT neurons in the raphe. Significant differences in the normalized area of serotonin (5-HT)-positive neurons in the raphe nucleus were observed between the control and SCH 23390–treated groups (df = 8). ∗P < 0.05. Scale bar = 100 μm. Ctrl, control.

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Acknowledgments

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