ZFIN Image: Henderson et al., 2023, Figure 1

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Figure 1

PR3 induces MGC formation in monocytes from patients with GPA. Monocytes from patients with GPA, patients with MPA and healthy controls were stimulated with PR3 and MPO (n=10) (A). There was a dose–response effect seen in patients with GPA with increasing MGC formation at PR3 10 µg/mL compared with patients with MPA and healthy controls. MPO did not stimulate MGC formation. HNE was also tested (B) and showed a similar increase in MGC formation in patients with GPA. Values plotted as median and 95% CI; *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Difference between conditions determined by one-way and two-way ANOVA tests. ANOVA, analysis of variance; GPA, granulomatosis with polyangiitis; HNE, human neutrophil elastase; MGC, multinucleated giant cells; MPA, microscopic polyangiitis; MPO, myeloperoxidase; PR3, proteinase 3; unstim, unstimulated.

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