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Fig. 5 The anti-RMS effects of candidate chemicals on RD xenografts in zebrafish embryos. (A) Vincristine reduced the SCSA at concentrations of 2 and 20 μmol/l, respectively. (B) Dactinomycin exhibited analogous anti-RMS effects compared with vincristine. (C) Vincristine and dactinomycin in combination did not show stronger anti-RMS effects compared with vincristine alone but had stronger inhibiting effects compared with dactinomycin alone. (D) The MEK-inhibitor trametinib also exerted dose-depending anti-RMS effects in vivo
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