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Figure 4
E2 signaling operates through Esr2b upstream of essential transcription factors to elicit distal nephron cell fate. (A) The 28 ss WT (top), 20 µM E2-treated (second row), 18 µM PHTPP-treated (third row), or esr2b MO-injected (bottom) animals stained via WISH for the transcription factor irx3b (left) and its downstream target irx1a (right). Scale bar = 100 µm for lower magnification, scale bar = 50 µm for higher magnification. (B,C) The irx3b and irx1a domain lengths at 28 ss in micrometers. Data presented on graphs are represented as mean ± SD. * p < 0.05 and **** p < 0.0001 (ANOVA).
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