ZFIN Image: Balamurugan et al., 2022, Fig. 8

Image

Figure Caption

Fig. 8

Graphical abstract of PHLPP1-mediated foam cell formation

PHLPP1 protein levels are elevated in OxLDL and ER stress-exposed macrophages and HFD-fed zebrafish larvae. PHLPP1 augmented cellular cholesterol and FFAs levels through the regulation of key lipogenic genes such as FASN, CD36, and so forth. Transcriptomic analysis revealed that loss of PHLPP1 suppresses gene expression associated with fatty acid synthesis and cholesterol metabolism. PHLPP1 promoted OxLDL-uptake in AMPK/CD36-dependent manner. Also, 7-kC treatment mediates the augmentation of ChREBP levels. Furthermore, PHLPP1 interacted with and dephosphorylated lipogenic transcription factor ChREBP and enhanced the levels of its target, FASN. Data from other studies suggest that AMPK assists in lipid efflux via upregulating ABCG1 levels. Thus, PHLPP1 mediates foam cell formation via ChREBP/AMPK axis (Green arrow indicates protein increase; purple arrow indicates data from other studies).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ iScience