IMAGE

Fig 3

ID
ZDB-IMAGE-220904-24
Source
Figures for Wang et al., 2022
Image
Figure Caption

Fig 3 Reduced SCC in esco2 and sgol1 haploinsufficient animals correlates with accelerated tumor onset.

(A) Representative images of “paired” and “railroad” (RR) metaphase spreads. Inset shows zoomed-in view of each phenotype. (B) The percentage of metaphase spreads in esco2+/+ and esco22865/+ showing paired or RR phenotypes. Two pools of embryos were used for esco2+/+ and esco22865/+ spreads from two independent experiments. A total of 92 esco2+/+ and 119 esco22865/+ spreads were tallied. (C) The percentage of spreads in sgo1+/+ and sgo1+/- showing paired or RR phenotypes. Three pools of embryos were used for sgo1+/+ and sgo1m/+ spreads. A total of 131 sgo1+/+ and 142 sgo1+/- spreads were tallied. ** p-value < 0.01 and *** p-value < 0.001 by paired t-test. (D) Kaplan-Meier curves for tumor-free survival for p53+/+, sgo1+/-; p53+/+, p53+/- and sgo1+/-; p53+/- cohorts. Cohorts were established by natural single-pair breeding of sgo1+/- X p53+2/+ parents (all cohorts were n = 96). P-value = <0.0001 when comparing p53+/- with sgo1+/-; p53+/- curves based on Log-rank (Mantel-Cox) test.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.