ZFIN Image: Arjun et al., 2022, Figure 5

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Figure 5

The NG conjugates were microinjected into the aortic region of zebrafish larvae to examine the possibility of crossing the BBB in vivo via apolipoprotein receptor-mediated endocytosis. NG + PS80, NG + Rh–B, and NG + Rh–B + PS80 bright field images of microinjected zebrafish larvae (transmitted), fluorescent image (fluorescence), and grayscale + fluorescent merged image (merged). NG + PS80 and NG + Rh–B overlapped image of grayscale and red fluorescence showed no targeted delivery of NG to the CNS due to lack of fluorescence property or inability to cross BBB, respectively. The NG + Rh–B + PS80 overlapped image of grayscale and red fluorescence shows targeted delivery of NG to CNS. The yellow marked region is the spinal cord of zebrafish larvae.

Acknowledgments

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