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Fig. 5
Fig. 5. Gsdme mediates pyroptotic cell death in neutrophil in zebrafish with skin inflammation. One-cell stage zebrafish eggs from Tg(mpx:gal4.vp16)/Tg(uas:gbp4) (see Fig. 4A) were microinjected with control or spint1a crRNA/Cas9 complexes. At 1 dpf, embryos were treated with the specific inhibitors of Gsdmea and Gsdmeb, Ac-SEVD-CMK (A) and Ac-FEID-CMK (B), respectively, and neutrophils were stained at 3 dpf with Sudan black. *p < 0.05; ***p < 0.001; n.s., non-significant.
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