Fig. 2

Figure 2. Transition analysis between cell clusters. (A) tSNE plot showing the main cell types in zebrafish when all genes annotated in zebrafish are used for clustering. (B) tSNE plot showing the main cell types in zebrafish when only the genes orthologous to humans are used for clustering. (C) Transition diagram between (A,B). When human orthologous genes are used, majority of the cell types remain in their clusters, with slight exception of a subset of oligodendrocytes, excitatory neurons, and inhibitory neurons that start clustering in astroglia. (D) tSNE plot showing the main cell types in humans when all genes annotated in humans are used for clustering. (E) tSNE plot showing the main cell types in humans when only the genes orthologous to zebrafish are used for clustering. (F) Transition diagram between (D,E). When zebrafish orthologous genes are used, the vast majority of the cell types remain in their clusters.