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Fig. 4
Macrophages recognize the core sequence to allow swallowing and digestion of invading plasmids. A Microinjection of plasmids into the central artery of zebrafish embryos. B qRT-PCR results showing reduced expression of isg15 12 h-post-injection when the core sequences in pEGFP-N1 are mutated. C, D Q-PCR results indicating that pEGFP-N1 was digested more rapidly than all mutant forms of pEGFP-N1. E Confocal scanning image showing macrophages swallowing free DNA fragments in zebrafish
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