ZFIN Image: Han et al., 2021, Figure 6

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Figure Caption

Figure 6

Effects of folic acid on partial gene methylation in zebrafish embryos. (A) The CpG island of hand2 gene for the BSP experiment was predicted and selected. (B) Zebrafish embryos with different folate metabolism groups BSP analysis of the locus of hand2. (C) The CpG island of gata4 gene for the BSP experiment was predicted and selected. (D) Zebrafish embryos with different folate metabolism groups BSP analysis of the locus of gata4. (E) Standard curve fitting based on the standard sample. (F) Methionine levels in heart cells of different folate treatment groups and mthfr homozygous mutants. (G) Relative methylated BSP analysis of the hand2 promoter locus. (H) Relative methylated BSP analysis of the gata4 promoter locus. (Student t-test, ** p < 0.01, *** p < 0.001, ns: no statistical difference).

Acknowledgments

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