ZFIN Image: Habjan et al., 2021, Fig. 2.

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Figure Caption

Fig. 2.

Screening a library of anti-mycobacterial compounds in zebrafish-infection model identifies 14 hit-compounds. (A) Schematic representation of the screen design. Compounds active against Mtb and M. marinum in vitro were tested in the zebrafish embryo-M. marinum yolk-infection model. (B) Hit compounds were tested in a dose-response assay. Each data point represents the integrated red fluorescence intensity of a single zebrafish embryo, and the signal of each group (10-20 embryos) is expressed as mean±s.e.m. Statistical significance was determined by one-way ANOVA, following Dunnett's multiple comparison test by comparing the signal from the DMSO-treated control sample with each treatment group (*P≤0.05, **P≤0.01, ***P≤0.001, ****P≤0.0001).

Acknowledgments

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